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A rare case of esophageal mucoepidermoid carcinoma successfully treated via endoscopic submucosal dissection

  • So Eun Jeun (Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital) ;
  • Kyung Bin Kim (Department of Pathology, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital) ;
  • Bong Eun Lee (Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital) ;
  • Gwang Ha Kim (Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital) ;
  • Moon Won Lee (Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital) ;
  • Dong Chan Joo (Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital)
  • 투고 : 2024.02.29
  • 심사 : 2024.03.07
  • 발행 : 2024.09.30

초록

Esophageal mucoepidermoid carcinoma (EMEC) is a special subtype of esophageal malignancy, accounting for less than 1% of all cases of primary esophageal carcinoma. Pathologically, it consists of a mixture of adenocarcinoma and squamous cell carcinoma with mucin-secreting cells. Special staining for mucicarmine helps to diagnose EMEC. We present a rare case of EMEC successfully treated via endoscopic submucosal dissection (ESD). A 63-year-old man was referred to our tertiary hospital. On esophagogastroduodenoscopy, a 6-mm-sized subtle reddish depressed lesion was identified in the mid-esophagus. Diagnostic ESD was performed with a high suspicion of carcinoma. Histopathologic findings were consistent with EMEC which was confined to the lamina propria without lymphatic invasion. We plan to do a careful follow-up without administering adjuvant chemotherapy or radiotherapy. Due to the small volume of the lesion, establishing a diagnosis was difficult through forceps biopsy alone. However, by using ESD, we could confirm and successfully treat a rare case of early-stage EMEC.

키워드

과제정보

This work was supported by clinical research grant from Pusan National University Hospital in 2024.

참고문헌

  1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359-E386.
  2. Jung HK. Epidemiology of and risk factors for esophageal cancer in Korea. Korean J Helicobacter Up Gastrointest Res 2019;19:145-148. https://doi.org/10.7704/kjhugr.2019.19.3.145
  3. Abnet CC, Arnold M, Wei WQ. Epidemiology of esophageal squamous cell carcinoma. Gastroenterology 2018;154:360-373. https://doi.org/10.1053/j.gastro.2017.08.023
  4. Hagiwara N, Tajiri T, Tajiri T, et al. Biological behavior of mucoepidermoid carcinoma of the esophagus. J Nippon Med Sch 2003;70:401-407. https://doi.org/10.1272/jnms.70.401
  5. Takubo K. Carcinomas other than squamous cell carcinoma and adenocarcinoma. In: Takubo K, editor. Pathology of the esophagus: an atlas and textbook. Springer; 2007. p. 212-225.
  6. McPeak E, Arons WL. Adenoacanthoma of the esophagus: a report of one case with consideration of the tumor's resemblance to so-called salivary gland tumor. Arch Pathol (Chic) 1947;44:385-390.
  7. Schizas D, Kapsampelis P, Mylonas KS. Adenosquamous carcinoma of the esophagus: a literature review. J Transl Int Med 2018;6:70-73. https://doi.org/10.2478/jtim-2018-0014
  8. Liu ZJ, Sun SY, Guo JT, et al. A primary esophageal mucoepidermoid carcinoma mimicking a benign submucosal tumor. Dis Esophagus 2012;25:178-179.
  9. Tamura S, Kobayashi K, Seki Y, et al. Mucoepidermoid carcinoma of the esophagus treated by endoscopic mucosal resection. Dis Esophagus 2003;16:265-267. https://doi.org/10.1046/j.1442-2050.2003.00342.x
  10. Stout AP, Latters RL. Tumor of the esophagus. In: Atlas of tumor pathology, Sect V, fasc 20. Armed Forces Institute of Pathology; 1957. p. 72-76.
  11. Kumagai Y, Ishiguro T, Kuwabara K, et al. Primary mucoepidermoid carcinoma of the esophagus: review of the literature. Esophagus 2014;11:81-88. https://doi.org/10.1007/s10388-014-0414-z
  12. Chen S, Chen Y, Yang J, et al. Primary mucoepidermoid carcinoma of the esophagus. J Thorac Oncol 2011;6:1426-1431. https://doi.org/10.1097/JTO.0b013e31821cfb96
  13. Koide N, Hamanaka K, Igarashi J, et al. Co-occurrence of mucoepidermoid carcinoma and squamous cell carcinoma of the esophagus: report of a case. Surg Today 2000;30:636-642. https://doi.org/10.1007/s005950070104
  14. Wang X, Chen YP, Chen SB. Esophageal mucoepidermoid carcinoma: a review of 58 cases. Front Oncol 2022;12:836352.
  15. Suzuki Y, Nomura K, Matsui A, et al. Long-term outcomes of endoscopic submucosal dissection for special type of esophageal cancer. Dig Dis 2023;41:533-542. https://doi.org/10.1159/000529590