Advances in nano research

  • 제17권3호
  • /
  • Pages.213-219
  • /
  • 2024
  • /
  • 2287-237X(pISSN)
  • /
  • 2287-2388(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

Nanotechnology-enabled diagnostics for the correlation between serum APN, Cystatin C and MMP-9 levels in patients with hypertension during pregnancy

  • Hui Deng (The People's Hospital of Yubei District of Chongqing City) ;
  • Yu-Lan Fan (The People's Hospital of Yubei District of Chongqing City) ;
  • Yu-Qi Wang (The People's Hospital of Yubei District of Chongqing City) ;
  • Yin Yang (Department of Infection Controlling Section, Women and Children's Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children)) ;
  • Da-Yong Jiang (Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital)
  • 투고 : 2024.04.17
  • 심사 : 2024.08.17
  • 발행 : 2024.09.25
⟨ 이전 논문 다음 논문 ⟩

초록

Nanotechnology is one of the critical factors involved in enhancing the sensitivity of serum biomarker detection. To explore the relationship between serum APN, Cystatin C and MMP-9 levels in patients with hypertension during pregnancy and the severity and prognosis of the disease. A total of 75 cases of hypertensive disorder complicating pregnancy (HDCP) patients who were admitted to the hospital from February 5, 2023 to May 9, 2024, were selected as the study group, and 70 healthy pregnant women who were in the same gestational week were selected as the control group. The serum APN, MMP-9 and Cys C levels of pregnant women and HDCP patients with different disease severity were compared between the two groups, and the receiver characteristic curve (ROC) was used to analyze its diagnostic value. The serum APN, MMP-9 and Cys C levels of HDCP patients with different prognosis were compared, and the factors affecting the prognosis of patients were analyzed by Logistic regression. Nanoparticles could aslo enable the sensitive detection and quantification of APN, Cystatin C, and MMP-9 in serum samples, thus increasing the accuracy of the study. The serum MMP-9 and Cys C levels of pregnant women in the study group were significantly increased, and the APN level was significantly decreased (P<0.05). Serum MMP-9 and Cys C levels in patients with pregnancy-induced hypertension, mild preeclampsia, and severe preeclampsia gradually increased (r=0.768, 0.766; P<0.001), and APN levels gradually decreased (r=-0.748, P< 0.001). In the diagnosis of patients with HDCP, the sensitivity, specificity and AUC of APN single diagnosis were 70.00%, 82.67% and 9.848 respectively. The sensitivity, specificity and AUC of MMP-9 single diagnosis were 82.86%, 74.67% and 298.300 respectively. The sensitivity, specificity and AUC of Cys C single diagnosis were 80.00%, 74.67% and 1.301 respectively. There were significant differences in age, BMI, parity, dysthymia, disease severity, APN, MMP-9 and Cys between patients with poor prognosis of HDCP and patients with good prognosis of HDCP (P<0.001). The patient's age, BMI, disease severity, APN, MMP-9 and Cys Cwere all related to HDCP. They were related risk factors of HDCP (P<0.05).

키워드

참고문헌

  1. Adu-Gyamfi, E.A., Fondjo, L.A., Owiredu, W.K., Czika, A., Nelson, W., Lamptey, J., Wang, Y. and Ding, Y. B. (2020), "The role of adiponectin in placentation and preeclampsia", Cell Biochem. Funct., 38(1), 106-117. https://doi.org/10.1002/cbf.3458.
  2. Behrens, I., Basit, S., Melbye, M., Lykke, J. A., Wohlfahrt, J., Bundgaard, H. and Boyd, H.A. (2016), "Risk of chronic hypertension in women with a history of hypertensive disorders of pregnancy - a nationwide cohort study", J. Mater. Fetal Neonatal Med., 29(S2), 21. https://doi.org/10.1136/bmj.j3078.
  3. Berghouti, H., Adda Bedia, E., Benkhedda, A. and Tounsi, A. (2023), "Vibration analysis of nonlocal porous nanobeams made of functionally graded material", Adv. Nano Res., 7(5), 351-364. http://doi.org/10.12989/anr.2023.7.5.351.
  4. Bernstein, P.S., Martin, J.N., Barton, J.R., Shields, L.E., Druzin, M.L., Scavone, B.M., ... and Menard, M.K. (2017), "National partnership for maternal safety: consensus bundle on severe hypertension during pregnancy and the postpartum period", Anesth. Analg., 125(2), 540-547. http://doi.org/10.1097/AOG.0000000000002115.
  5. Bilouei, B.S., Kolahchi, R., and Bidgoli, M.R. (2018), "Buckling of beams retrofitted with Nano-Fiber Reinforced Polymer (NFRP)", Comput. Concr, 18, 1053-106, https://doi.org/10.12989/cac.2016.18.6.1053.
  6. Chen, S., Li, N., Mei, Z., Ye, R., Li, Z., Liu, J. and Serdula, M.K. (2019), "Micronutrient supplementation during pregnancy and the risk of pregnancy-induced hypertension: A randomized clinical trial", Clin. Nutr., 38(1), 146-151. https://doi.org/10.1016/j.clnu.2018.01.029.
  7. Correa, S., Morrow, D.A., Braunwald, E., Davies, R.Y., Goodrich, E.L., Murphy, S.A., Cannon, C.P. and O'Donoghue, M.L. (2018), "Cystatin C for risk stratification in patients after an acute coronary syndrome", J. Am. Heart Assoc., 7(20), e009077. https://doi.org/10.1161/JAHA.118.00907.
  8. Fan, Z., Liu, Y., Ye, Y., and Liao, Y. (2024), "Functional probes for the diagnosis and treatment of infectious diseases", Aggregate, e620. https://doi.org/10.1002/agt2.620
  9. Fu, Q., Chen, R., Xu, S., Ding, Y., Huang, C., He, B., Jiang, T., Zeng, B., Bao, M., and Li, S. (2024), "Assessment of potential risk factors associated with gestational diabetes mellitus: evidence from a Mendelian randomization study", Front Endocrinol, 14, 1276836. https://doi.org/10.3389/fendo.2023.1276836.
  10. Gong, H., Tao, S., Rajendran, K., Zhou, W., McCollough, C.H. and Leng, S. (2019), "Deep-learning-based direct inversion for material decomposition", Med. Phys., 47(12), 6294-6309. https://doi.org/10.1002/mp.14523.
  11. Guglielminotti, J., Landau, R., Friedman, A.M. and Li, G. (2019), "Pulmonary hypertension during pregnancy in New York State, 2003-2014", Mater. Child Health J., 23(2), 277-284. https://doi.org/10.1007/s10995-018-2652-5.
  12. Hu, J., Xu, T., Shen, H., Song, Y., Yang, J., Zhang, A., and Chongqing, P.A.S.C. (2023), "Accuracy of Gallium-68 pentixafor positron emission tomography-computed tomography for subtyping diagnosis of primary aldosteronism", JAMA Network Open, 6(2), e2255609. https://doi.org/10.1001/jamanetworkopen.2022.55609
  13. Hu, R., and Feng, H. (2017), "Lenticulostriate artery and lenticulostriate-artery neural complex: new concept for intracerebral hemorrhage", Curr. Pharm. Des., 23(15), 2206-2211. https://doi.org/10.2174/1381612823666170220163750.
  14. Kreepala, C., Srila-on, A., Kitporntheranunt, M., Anakkamatee, W., Lawtongkum, P. and Wattanavaekin, K. (2019), "The association between GFR evaluated by serum cystatin C and proteinuria during pregnancy", Kidney Int. Rep., 4(6), 854-863. https://doi.org/10.1016/j.ekir.2019.04.004.
  15. Le, J. (2008), Obstetrics and Gynecology, People's Medical Publishing House, Beijing, China.
  16. Li, X., Chen, C., Wei, L., Li, Q., Niu, X., Xu, Y., Wang, Y. and Zhao, J. (2016), "Exosomes derived from endothelial progenitor cells attenuate vascular repair and accelerate reendothelialization by enhancing endothelial function", Cytotherapy, 18(2), 253-262. https://doi.org/10.3389/fcvm.2021.734562.
  17. Li, X., Liang, J., Hu, J., Ma, L., Yang, J., Zhang, A., and On, B.O. T.C. (2024), "Screening for primary aldosteronism on and off interfering medications", Endocrine, 83(1), 178-187. https://doi.org/10.1007/s12020-023-03520-6
  18. Lin, S.P., Shi, Y.T., Wei, Q.M., Zheng, C.G. and Tian, X.P. (2018), "Effects of telmisartan on serum adiponectin and left ventricular remodeling in patients with essential hypertension", Biomed. Res., 29(7), 1455-1458. https://doi.org/10.1177/1535370220908215.
  19. Liu, L., Huang, X., Gao, J., Di, Y., Sun, S., Deng, X. and Cao, J. (2018), "Improved endogenous epoxyeicosatrienoic acid production mends heart function via increased PGC-1α-mitochondrial functions in metabolic syndrome", J. Pharmacol. Sci., 138(2), 138-145. https://doi.org/10.1016/j.jphs.2018.09.010.
  20. Lu, Y., Li, J., Liu, Y., Zhu, L., Xiao, S., Bai, M. and Xie, T. (2023), "Bi-enzyme competition based on ZIF-67 co-immobilization for real-time monitoring of exocellular ATP", Microchimica Acta, 190(2), 71. https://doi.org/10.1007/s00604-023-05652-y
  21. Madsen, C., Haberg, S.E., Aamodt, G., Stigum, H., Magnus, P., London, S.J., Nystad, W. and Nafstad, P. (2018), "Preeclampsia and hypertension during pregnancy in areas with relatively low levels of traffic air pollution", Matern. Child Health J., 22(4), 512-519. https://doi.org/10.1007/s10995-017-2417-6.
  22. Mehar, K. and Panda, S.K. (2023), "Multiscale modeling approach for thermal buckling analysis of nanocomposite curved structure", Adv. Nano Res., 7(3), 181. http://doi.org/10.12989/anr.2023.7.3.181.
  23. Okusanya, B.O., Oladapo, O.T., Long, Q., Lumbiganon, P., Carroli, G., Qureshi, Z., Duley, L., Souza, J.P. and Gulmezoglu, A.M. (2016), "Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia", BJOG, 123(3), 356-366. https://doi.org/10.1111/1471-0528.13753.
  24. Pandey, H.K., Hirwani, C.K., Sharma, N., Katariya, P.V., Dewangan, H.C. and Panda, S.K. (2023), "Effect of nano glass cenosphere filler on hybrid composite eigenfrequency responses-An FEM approach and experimental verification", Adv. Nano Res., 7(6), 419-429 http://doi.org/10.12989/anr.2023.7.6.419.
  25. Peri-Okonny, P.A., Ayers, C., Maalouf, N., Das, S.R., de Lemos, J.A., Berry, J.D., Turer, A.T., Neeland, I.J., Scherer, P.E. and Vongpatanasin, W. (2017), "Adiponectin protects against incident hypertension independent of body fat distribution: Observations from the Dallas Heart Study", Diabetes Metab. Res. Rev., 33(2), e2840. https://doi.org/10.1002/dmrr.2840.
  26. Ren, Z., Cui, N., Zhu, M. and Khalil, R.A. (2018), "Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy", Am. J. Physiol. Heart Circ. Physiol., 315(1), H33-H47. https://doi.org/10.1152/ajpheart.00045.2018.
  27. Rohrbach, S., Troidl, C., Hamm, C. and Schulz, R. (2015), "Ischemia and reperfusion related myocardial inflammation: A network of cells and mediators targeting the cardiomyocyte", IUBMB Life, 67(2), 110-119. https://doi.org/10.1002/iub.1352.
  28. Salama, M., Rezk, M., Gaber, W., Hamza, H., Marawan, H., Gamal, A. and Abdallah, S. (2019), "Methyldopa versus nifedipine or no medication for treatment of chronic hypertension during pregnancy: A multicenter randomized clinical trial", Pregnancy Hypertens., 17, 54-58. https://doi.org/10.1016/j.preghy.2019.05.009.
  29. Schachter, A., Lai, M., Heard, A.J., Hagan, J., Grant, J. and Stafford, I.A. (2019), "Effect of magnesium sulfate on B-type natriuretic peptide (BNP) levels in hypertensive disease of pregnancy", Obstet. Gynecol., 133, 69S-60S. https://doi.org/10.1097/01.AOG.0000559057.41897.84.
  30. Shi, W., Deng, D., Wang, Y., Hu, G., Guo, J., Zhang, X., et al. (2016), "Causes of endocrine disrupting potencies in surface water in east china", Chemosphere, 144, 1435-1442. https://doi.org/10.1016/j.chemosphere.2015.09.018
  31. Shin, N.M., Yoon, J.W., Choi, J., Park, Y. and Jeon, S. (2016), "A pilot study of APN-led self-management program to improve cardiovascular health status among Korean women with risk factors", Korean J. Adult Nurs., 28(2), 237-245. https://doi.org/10.7475/kjan.2016.28.2.237.
  32. Sun, T., Lv, J., Zhao, X., Li, W., Zhang, Z., and Nie, L. (2023), "In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging", Photoacoustics, 34, 100569. https://doi.org/10.1016/j.pacs.2023.100569
  33. Vigil-De Gracia, P., Ramirez, R., Duran, Y. and Quintero, A. (2017), "Magnesium sulfate for 6 vs 24 hours post delivery in patients who received magnesium sulfate for less than 8 hours before birth: A randomized clinical trial", BMC Pregnancy Childbirth, 17(1), 241. https://doi.org/10.1186/s12884-017-1424-3.
  34. Wang, Y., Shi, D. and Chen, L. (2018), "Lipid profile and cytokines in hypertension of pregnancy: A comparison of preeclampsia therapies", J. Clin. Hypertens., 20(2), 394-399. https://doi.org/10.1111/jch.13161.
  35. Webster, L.M., Reed, K., Myers, J.E., Burns, A., Gupta, P., Patel, P., Wiesender, C., Seed, P.T., Nelson-Piercy, C. and Chappell, L.C. (2019), "Quantifying adherence to antihypertensive medication for chronic hypertension during pregnancy", Pregnancy Hypertens., 17, 12-14. https://doi.org/10.1016/j.preghy.2019.05.004.
  36. Xia, K., Shan, S. and Zhao, B. (2017), "Clinical efficacy of low molecular weight heparin calcium combined with Bailing capsule on children with allergic purpura nephritis and its effect on serum hs-CRP, MMP-9, APN and CysC", Chin. J. Biochem. Pharmaceut., 7(5), 106-109. https://doi.org/10.3109/0886022X.2015.1061668.
  37. Yang, W., Ding, N., Luo, R., Zhang, Q., Li, Z., Zhao, F. and Hu, R. (2023), "Exosomes from young healthy human plasma promote functional recovery from intracerebral hemorrhage via counteracting ferroptotic injury", Bioact. Mater., 27, 1-14. https://doi.org/10.1016/j.bioactmat.2023.03.007
  38. Zamanian, M., Kolahchi, R., and Bidgoli, M.R. (2017), "Agglomeration effects on the buckling behaviour of embedded beams reinforced with SiO2 nano-particles", Wind. Struct., 24(1), 43-57. https://doi.org/10.12989/was.2017.24.1.043.
  39. Zhang, J., Xia, L., Zhang, F., Zhu, D., Xin, C., Wang, H., ... & Tao, L. (2017), "A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation", Biochim. Biophys. Acta Mol. Basis Dis., 1863(6), 1556-1567. https://doi.org/10.1016/j.bbadis.2017.02.012.
  40. Zhang, J., Xia, L., Zhang, F., Zhu, D., Xin, C., Wang, H., ... & Tao, L. (2019), "MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy", Exp. Ther. Med., 18(1), 637-641. https://doi.org/10.3892/etm.2019.7591.