Clinical and Experimental Reproductive Medicine

  • 제51권3호
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  • Pages.268-275
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  • 2024
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Outcomes of female reproductive performance with assisted reproductive techniques after recent mild to moderate COVID-19 infections: An observational study

  • Ashraf Moini (Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences) ;
  • Narges Najafpour (Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences) ;
  • Ladan Kashani (Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences) ;
  • Maryam Farid-Mojtahedi (Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences) ;
  • Arezoo Maleki-Hajiagha (Department of Anatomy, School of Medicine, Tehran University of Medical Sciences) ;
  • Afsaneh Tehranian (Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences) ;
  • Rana Karimi (Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences)
  • 투고 : 2023.07.21
  • 심사 : 2023.12.14
  • 발행 : 2024.09.30
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초록

Objective: The purpose of this study was to evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on clinical outcomes among high-risk patients. Methods: This retrospective study involved 1,368 patients and the same number of cycles, including 520 cycles with PGT-A and 848 cycles without PGT-A. The study participants comprised women of advanced maternal age (AMA) and those affected by recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), or severe male factor infertility (SMF). Results: PGT-A was associated with significant improvements in the implantation rate (IR) and the ongoing pregnancy rate/live birth rate (OPR/LBR) per embryo transfer cycle in the AMA (39.3% vs. 16.2% [p<0.001] and 42.0% vs. 21.8% [p<0.001], respectively), RIF (41.7% vs. 22.0% [p<0.001] and 47.0% vs. 28.6% [p<0.001], respectively), and RPL (45.6% vs. 19.5% [p<0.001] and 49.1% vs. 24.2% [p<0.001], respectively) groups, as well as the IR in the SMF group (43.3% vs. 26.5%, p=0.011). Additionally, PGT-A was associated with lower overall incidence rates of pregnancy loss in the AMA (16.7% vs. 34.3%, p=0.001) and RPL (16.7% vs. 50.0%, p<0.001) groups. However, the OPR/LBR per total cycle across all PGT-A groups did not significantly exceed that for the control groups. Conclusion: PGT-A demonstrated beneficial effects in high-risk patients. However, our findings indicate that these benefits are more pronounced in carefully selected candidates than in the entire high-risk patient population.

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참고문헌

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