Journal of Periodontal and Implant Science

  • 제54권4호
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  • Pages.236-252
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  • 2024
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
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Comparison of early wound healing using modified papilla preservation technique between enamel matrix derivative and recombinant human fibroblast growth factor

  • Yohei Nakayama (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Shinichi Tabe (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Kazuma Igarashi (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Satoshi Moriya (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Tsuyoshi Katsumata (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Ryo Kobayashi (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Shuta Nakagawa (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Tomoko Nishino (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Namiko Fukuoka (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Kota Hosono (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Mai Yamasaki (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Yosuke Yamazaki (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Moe Ogihara-Takeda (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Shoichi Ito (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Yumi Saito (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Arisa Yamaguchi (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Yuto Tsuruya (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Mizuho Yamazaki-Takai (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Shoichi Yoshino (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Hideki Takai (Department of Periodontology, Nihon University School of Dentistry at Matsudo) ;
  • Yorimasa Ogata (Department of Periodontology, Nihon University School of Dentistry at Matsudo)
  • 투고 : 2023.07.04
  • 심사 : 2023.10.05
  • 발행 : 2024.08.31
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Abstract

Purpose: Enamel matrix derivative (EMD) has demonstrated beneficial effects on wound healing following surgery. However, the effects of recombinant human fibroblast growth factor 2 (rhFGF-2) in periodontal regeneration therapy have not been extensively studied. This retrospective study was conducted to compare the wound healing outcomes of the modified papilla preservation technique (mPPT) between EMD and rhFGF-2 therapies. Methods: A total of 79 sites were evaluated for early wound healing using the modified early wound healing index (mEHI), which included 6 items: incision, fibrin clotting, step, redness, swelling, and dehiscence. A numeric analog scale, along with postoperative images of the 6 mEHI items, was established and used for the evaluations. The inter-rater reliability of the mEHI was assessed via intraclass correlation coefficients (ICCs). After adjusting for factors influencing the mPPT, the differences in mEHI scores between the EMD and rhFGF-2 groups were statistically analyzed. Additionally, radiographic bone fill (RBF) was evaluated 6 months after surgery. Results: The ICC of the mEHI was 0.575. The mEHI, redness score, and dehiscence scores were significantly higher in the rhFGF-2 group (n=33) than in the EMD group (n=46). Similar results were observed in the subgroup of patients aged 50 years or older, but not in those younger than 50 years. In the subgroup with non-contained bone defects, related results were noted, but not in the subgroup with contained bone defects. However, early wound healing did not correlate with RBF at 6 months after surgery. Conclusions: Within the limitations of this study, the findings suggest that early wound healing following the use of mPPT with rhFGF-2 is somewhat superior to that observed after mPPT with EMD. However, mEHI should be improved for use as a predictive tool for early wound healing and to reflect clinical outcomes after surgery.

Keywords

Acknowledgement

This study received partial support from the Japan Society for the Promotion of Science (Chiyoda, Tokyo, Japan) through the KAKENHI Grants-in-Aid for Scientific Research (C), No. 21K09921, awarded to Y. N. We extend our thanks to Emiri Wada and Ayako Kato for their evaluation of wound healing by modified early wound healing index (mEHI).

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