과제정보
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2022R1I1A3070740).
참고문헌
- Yang H, Xiong X, Wang X, Tan B, Li T, Yin Y. Effects of weaning on intestinal upper villus epithelial cells of piglets. PLOS ONE. 2016;11:e0150216. https://doi.org/10.1371/journal.pone.0150216
- Jang HJ, Lee SI. MicroRNA expression profiling during the suckling-to-weaning transition in pigs. J Anim Sci Technol. 2021;63:854-63. https://doi.org/10.5187/jast.2021.e69
- Kang R, Li R, Dai P, Li Z, Li Y, Li C. Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production. Environ Pollut. 2019;251:689-98. https://doi.org/10.1016/j.envpol.2019.05.026
- Yi H, Hu W, Chen S, Lu Z, Wang Y. Cathelicidin-WA improves intestinal epithelial barrier function and enhances host defense against enterohemorrhagic Escherichia coli O157:H7 infection. J Immunol. 2017;198:1696-705. https://doi.org/10.4049/jimmunol.1601221
- Mun D, Kyoung H, Kong M, Ryu S, Jang KB, Baek J, et al. Effects of Bacillus-based probiotics on growth performance, nutrient digestibility, and intestinal health of weaned pigs. J Anim Sci Technol. 2021;63:1314-27. https://doi.org/10.5187/jast.2021.e109
- Gallo RL, Hooper LV. Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 2012;12:503-16. https://doi.org/10.1038/nri3228
- Ren Z, Guo C, Yu S, Zhu L, Wang Y, Hu H, et al. Progress in mycotoxins affecting intestinal mucosal barrier function. Int J Mol Sci. 2019;20:2777. https://doi.org/10.3390/ijms20112777
- Gao Y, Meng L, Liu H, Wang J, Zheng N. The compromised intestinal barrier induced by mycotoxins. Toxins. 2020;12:619. https://doi.org/10.3390/toxins12100619
- Zhang C, Zhang KF, Chen FJ, Chen YH, Yang X, Cai ZH, et al. Deoxynivalenol triggers porcine intestinal tight junction disorder: insights from mitochondrial dynamics and mitophagy. Ecotoxicol Environ Saf. 2022;248:114291. https://doi.org/10.1016/j.ecoenv.2022.114291
- Liao S, Tang S, Tan B, Li J, Qi M, Cui Z, et al. Chloroquine improves deoxynivalenol-induced inflammatory response and intestinal mucosal damage in piglets. Oxid Med Cell Longev. 2020;2020:9834813. https://doi.org/10.1155/2020/9834813
- Garcia GR, Payros D, Pinton P, Dogi CA, Laffitte J, Neves M, et al. Intestinal toxicity of deoxynivalenol is limited by Lactobacillus rhamnosus RC007 in pig jejunum explants. Arch Toxicol. 2018;92:983-93. https://doi.org/10.1007/s00204-017-2083-x
- Wang S, Yang J, Zhang B, Wu K, Yang A, Li C, et al. Deoxynivalenol impairs porcine intestinal host defense peptide expression in weaned piglets and IPEC-J2 cells. Toxins. 2018;10:541. https://doi.org/10.3390/toxins10120541
- Yao Y, Long M. The biological detoxification of deoxynivalenol: a review. Food Chem Toxicol. 2020;145:111649. https://doi.org/10.1016/j.fct.2020.111649
- Colovic R, Puvaca N, Cheli F, Avantaggiato G, Greco D, Duragic O, et al. Decontamination of mycotoxin-contaminated feedstuffs and compound feed. Toxins. 2019;11:617. https://doi.org/10.3390/toxins11110617
- Hussein HS, Brasel JM. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology. 2001;167:101-34. https://doi.org/10.1016/S0300-483X(01)00471-1
- Yang Y, Huang J, Li J, Yang H, Yin Y. The effects of lauric acid on IPEC-J2 cell differentiation, proliferation, and death. Curr Mol Med. 2020;20:572-81. https://doi.org/10.2174/1566524020666200128155115
- Surendra KC, Tomberlin JK, van Huis A, Cammack JA, Heckmann LHL, Khanal SK. Rethinking organic wastes bioconversion: evaluating the potential of the black soldier fly (Hermetia illucens (L.)) (Diptera: stratiomyidae) (BSF). Waste Manag. 2020;117:58-80. https://doi.org/10.1016/j.wasman.2020.07.050
- Jia M, Zhang Y, Gao Y, Ma X. Effects of medium chain fatty acids on intestinal health of monogastric animals. Curr Protein Pept Sci. 2020;21:777-84. https://doi.org/10.2174/1389203721666191231145901
- Lauridsen C. Effects of dietary fatty acids on gut health and function of pigs pre- and post-weaning. J Anim Sci. 2020;98:skaa086. https://doi.org/10.1093/jas/skaa086
- Jackman JA, Boyd RD, Elrod CC. Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation. J Anim Sci Biotechnol. 2020;11:44. https://doi.org/10.1186/s40104-020-00446-1
- Zheng C, Chen Z, Yan X, Xiao G, Qiu T, Ou J, et al. Effects of a combination of lauric acid monoglyceride and cinnamaldehyde on growth performance, gut morphology, and gut microbiota of yellow-feathered broilers. Poult Sci. 2023;102:102825. https://doi.org/10.1016/j.psj.2023.102825
- Vandenbroucke V, Croubels S, Martel A, Verbrugghe E, Goossens J, Van Deun K, et al. The mycotoxin deoxynivalenol potentiates intestinal inflammation by Salmonella typhimurium in porcine ileal loops. PLOS ONE. 2011;6:e23871. https://doi.org/10.1371/journal. pone.0023871
- Chen J, Huang Z, Cao X, Chen X, Zou T, You J. Plant-derived polyphenols as Nrf2 activators to counteract oxidative stress and intestinal toxicity induced by deoxynivalenol in swine: an emerging research direction. Antioxidants. 2022;11:2379. https://doi.org/10.3390/antiox11122379
- Yoon JW, Lee SI. Gene expression profiling after ochratoxin a treatment in small intestinal epithelial cells from pigs. J Anim Sci Technol. 2022;64:842-53. https://doi.org/10.5187/jast.2022.e49
- Tang M, Yuan D, Liao P. Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress by regulating the NF-κB/MAPK signaling pathway in deoxynivalenol-challenged piglets. Environ Pollut. 2021;289:117865. https://doi.org/10.1016/j.envpol.2021.117865
- Tham YY, Choo QC, Muhammad TST, Chew CH. Lauric acid alleviates insulin resistance by improving mitochondrial biogenesis in THP-1 macrophages. Mol Biol Rep. 2020;47:9595-607. https://doi.org/10.1007/s11033-020-06019-9
- Wu Y, Zhang H, Zhang R, Cao G, Li Q, Zhang B, et al. Serum metabolome and gut microbiome alterations in broiler chickens supplemented with lauric acid. Poult Sci. 2021;100:101315. https://doi.org/10.1016/j.psj.2021.101315
- Zeng X, Yang Y, Wang J, Wang Z, Li J, Yin Y, et al. Dietary butyrate, lauric acid and stearic acid improve gut morphology and epithelial cell turnover in weaned piglets. Anim Nutr. 2022;11:276-82. https://doi.org/10.1016/j.aninu.2022.07.012
- Liu Z, Xie W, Zan G, Gao C, Yan H, Zhou J, et al. Lauric acid alleviates deoxynivalenol-induced intestinal stem cell damage by potentiating the Akt/mTORC1/S6K1 signaling axis. Chem Biol Interact. 2021;348:109640. https://doi.org/10.1016/j.cbi.2021.109640
- Wang X, Zhang Y, Zhao J, Cao L, Zhu L, Huang Y, et al. Deoxynivalenol induces inflammatory injury in IPEC-J2 Cells via NF-κB signaling pathway. Toxins. 2019;11:733. https://doi.org/10.3390/toxins11120733
- Xu X, Lai Y, Hua ZC. Apoptosis and apoptotic body: disease message and therapeutic target potentials. Biosci Rep. 2019;39:BSR20180992. https://doi.org/10.1042/BSR20180992
- Negroni A, Cucchiara S, Stronati L. Apoptosis, necrosis, and necroptosis in the gut and intestinal homeostasis. Mediators Inflamm. 2015;2015:250762. https://doi.org/10.1155/2015/250762
- Kang TH, Kang KS, Lee SI. Deoxynivalenol induces apoptosis via FOXO3a-signaling pathway in small-intestinal cells in pig. Toxics. 2022;10:535. https://doi.org/10.3390/toxics10090535
- Leard LE, Broaddus VC. Mesothelial cell proliferation and apoptosis. Respirology. 2004;9:292-9. https://doi.org/10.1111/j.1440-1843.2004.00602.x
- Zhao W, Zhang X, Zhou Z, Sun B, Gu W, Liu J, et al. Liraglutide inhibits the proliferation and promotes the apoptosis of MCF-7 human breast cancer cells through downregulation of microRNA-27a expression. Mol Med Rep. 2018;17:5202-12. https://doi.org/10.3892/mmr.2018.8475
- Hagenbuchner J, Ausserlechner MJ. Mitochondria and FOXO3: breath or die. Front Physiol. 2013;4:147. https://doi.org/10.3389/fphys.2013.00147
- Melnik BC. Apoptosis may explain the pharmacological mode of action and adverse effects of isotretinoin, including teratogenicity. Acta Derm Venereol. 2017;97:173-81. https://doi.org/10.2340/00015555-2535
- Brunet A, Datta SR, Greenberg ME. Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol. 2001;11:297-305. https://doi.org/10.1016/S0959-4388(00)00211-7
- Eskandari E, Eaves CJ. Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis. J Cell Biol. 2022;221:e202201159. https://doi.org/10.1083/jcb.202201159
- Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 1998;391:43-50. https://doi.org/10.1038/34112
- Larsen BD, Sorensen CS. The caspase-activated DNase: apoptosis and beyond. FEBS J. 2017;284:1160-70. https://doi.org/10.1111/febs.13970
- Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N. Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta Mol Cell Res. 2013;1833:3448-59. https://doi.org/10.1016/j.bbamcr.2013.06.001
- Zhang X, Tang N, Hadden TJ, Rishi AK. Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta Mol Cell Res. 2011;1813:1978-86. https://doi.org/10.1016/j.bbamcr.2011.03.010
- Snoeks L, Weber CR, Turner JR, Bhattacharyya M, Wasland K, Savkovic SD. Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. Infect Immun. 2008;76:4677-85. https://doi.org/10.1128/IAI.00227-08