Journal of Animal Science and Technology

  • 제66권3호
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  • Pages.443-456
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  • 2024
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  • 2672-0191(pISSN)
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  • 2055-0391(eISSN)
한국축산학회 (Korean Society of Animal Sciences and Technology)
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Sperm hyperactivation and the CatSper channel: current understanding and future contribution of domestic animals

  • Jae Yeon Hwang (Department of Molecular Biology, Pusan National University)
  • 투고 : 2023.09.08
  • 심사 : 2023.11.29
  • 발행 : 2024.05.31
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초록

In female tract, mammalian sperm develop hyperactivated motility which is a key physiological event for sperm to fertilize eggs. This motility change is triggered by Ca2+ influx via the sperm-specific Ca2+ channel, CatSper. Although previous studies in human and mice largely contributed to understanding CatSper and Ca2+ signaling for sperm hyperactivation, the differences on their activation mechanisms are not well understood yet. There are several studies to examine expression and significance of the CatSper channel in non-human and non-mouse models, such as domestic animals. In this review, I summarize key knowledge for the CatSper channel from previous studies and propose future aspects for CatSper study using sperm from domestic animals.

키워드

과제정보

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. RS-2023-00210046).

참고문헌

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