Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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The storage mite Tyrophagus putrescentiae induces greater lung inflammation than house dust mites in mice

  • Eun-Min Kim (Institute of Tropical Medicine and Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine) ;
  • Ju Yeong Kim (Institute of Tropical Medicine and Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine) ;
  • You Shine Kwak (Institute of Tropical Medicine and Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine) ;
  • Myung-Hee Yi (Institute of Tropical Medicine and Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine) ;
  • Tai-Soon Yong (Institute of Tropical Medicine and Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine)
  • Received : 2024.04.22
  • Accepted : 2024.07.03
  • Published : 2024.08.31
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Abstract

Exposure to storage mite (SM) and house dust mite (HDM) allergens is a risk factor for sensitization and asthma development; however, the related immune responses and their pathology have not been fully investigated. The HDMs Dermatophagoides farinae and Dermatophagoides pteronyssinus and SM Tyrophagus putrescentiae are potent allergens that induce asthma. Most SM-related studies have focused on the allergic reactions of individuals by measuring their immunoglobulin (Ig)E expression. Considering the limited research on this topic, the present study aims to investigate the differences in the immune responses induced by HDMs and SMs and histologically analyze lung tissues in a mouse asthma model to understand the differential effects of HDM and SM. The results revealed that all mite species induced airway inflammation. Mice challenged with T. putrescentiae had the highest airway resistance and total cell, eosinophil, and neutrophil counts in the bronchoalveolar lavage fluid (BALF). The SM-sensitized groups showed more severe lesions and mucus hypersecretions than the HDM-sensitized groups. Although the degree of HDM and SM exposure was the same, the damage to the respiratory lung tissue was more severe in SM-exposed mice, which resulted in excessive mucin secretion and increased fibrosis. Furthermore, these findings suggest that SM sensitization induces a more significant hypersensitivity response in mucosal immunity than HDM sensitization in asthma models.

Keywords

Acknowledgement

We would like to thank Mr. Sung-Hyun Nam and Mr. In-Yong Lee for providing the HDM samples.

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