Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Carnosine and Retinol Synergistically Inhibit UVB-Induced PGE2 Synthesis in Human Keratinocytes through the Up-Regulation of Hyaluronan Synthase 2

  • In Guk Park (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Sun Hee Jin (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Seungchan An (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Min Won Ki (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Won Seok Park (Basic Research & Innovation Division, AmorePacific Corporation R&I Center) ;
  • Hyoung-June Kim (Basic Research & Innovation Division, AmorePacific Corporation R&I Center) ;
  • Yongjoo Na (Basic Research & Innovation Division, AmorePacific Corporation R&I Center) ;
  • Minsoo Noh (Natural Products Research Institute, College of Pharmacy, Seoul National University)
  • Received : 2023.12.22
  • Accepted : 2024.02.09
  • Published : 2024.09.01
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Abstract

Skin aging results from complex interactions of intrinsic and extrinsic factors, leading to structural and biochemical changes such as wrinkles and dryness. Ultraviolet (UV) irradiation leads to the degradation of hyaluronic acid (HA) in the skin, and the fragmented HA contributes to inflammation. This study revealed that the synergistic combination of carnosine and retinol (ROL) increases HA production in normal human epidermal keratinocytes (NHEKs) by upregulating hyaluronan synthase 2 (HAS2) gene transcription. Simultaneously, the combined treatment of carnosine and ROL significantly attenuates UVB-induced prostaglandin E2 (PGE2) synthesis in NHEKs. A significant correlation exists between the increase of HA synthesis and the inhibition of PGE2 production. This study suggests that combined treatment of carnosine and ROL can improve skin aging phenotypes associated with UVB irradiation.

Keywords

Acknowledgement

This study was partly supported by the National Research Foundation of Korea (NRF) grants funded by the Korea government (MIST) (RS-2024-00351858, and NRF-2022M3A9B6017654).

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