Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Pyronaridine Inhibited MUC5AC Mucin Gene Expression by Regulation of Nuclear Factor Kappa B Signaling Pathway in Human Pulmonary Mucoepidermoid Cells

  • Rajib Hossain (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Hyun Jae Lee (Smith Liberal Arts College and Department of Addiction Science Graduate School, Sahmyook University) ;
  • Choong Jae Lee (Department of Pharmacology, School of Medicine, Chungnam National University)
  • Received : 2024.05.04
  • Accepted : 2024.06.19
  • Published : 2024.09.01
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Abstract

In this study, the potential effects of pyronaridine, an antimalarial agent, on airway MUC5AC mucin gene expression were investigated. The human pulmonary epithelial NCI-H292 cells were pretreated with pyronaridine for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 h. The effect of pyronaridine on the PMA-induced nuclear factor kappa B (NF-κB) signaling pathway was also examined. Pyronaridine inhibited glycoprotein production and mRNA expression of MUC5AC mucins induced by PMA through the inhibition of degradation of inhibitory kappa Bα and NF-κB p65 nuclear translocation. These results suggest that pyronaridine suppresses gene expression of mucin through regulation of the NF-κB signaling pathway in human pulmonary epithelial cells.

Keywords

Acknowledgement

This research was supported by the NRF-2014R1A6A1029617 Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education.

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