생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제31권1호
  • /
  • Pages.1-6
  • /
  • 2024
  • /
  • 1225-8709(pISSN)
  • /
  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지
DOI QR코드

DOI QR Code

ALDH2 유전자형에 따라 나이, 성별로 나누어 비교한 혈중 아세트알데히드 농도에 관한 연구

Comparison Study on the Blood Acetaldehyde Concentration According to ALDH2 Genotype, Age, Gender

  • 주병욱 (양산부산대학교병원 정신건강의학과) ;
  • 정지운 (양산부산대학교병원 정신건강의학과) ;
  • 최세라 (양산부산대학교병원 정신건강의학과) ;
  • 이정석 (양산부산대학교병원 정신건강의학과) ;
  • 허성영 (양산부산대학교병원 정신건강의학과) ;
  • 김현경 (부산대학교 의생명융합연구원) ;
  • 김성곤 (양산부산대학교병원 정신건강의학과)
  • Byung-Uk Joo (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Ji-Woon Jeong (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Se Ra Choi (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Jung Seok Lee (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Sung Young Huh (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Hyeon-Kyeong Kim (Medical research institute, Pusan National University) ;
  • Sung-Gon Kim (Department of Psychiatry, Pusan National University Yangsan Hospital)
  • 투고 : 2023.09.21
  • 심사 : 2023.10.25
  • 발행 : 2024.04.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives Alcohol is metabolized to acetaldehyde by alcohol dehydrogenase enzyme in the liver and then acetaldehyde is metabolized to acetone by aldehyde dehydrogenase (ALDH) in the liver. There are two main ALDH enzymes which metabolize the acetaldehyde produced during ethanol oxidation. In particular, in the presence of the ALDH2 1*2 allele, the activity of the ALDH 2 enzyme is lowered. As a result, acetaldehyde metabolism is slowed down and acetaldehyde accumulates in the body compared to the ALDH2 1*1 allele. There are many studies that have investigated the blood acetaldehyde concentration according to the ALDH2 genotype, but there are few studies to compare this with age. So we investigated the blood acetaldehyde concentration according to ALDH2 genotype, age and gender. Methods According to the ALDH2 genotype, we divided the group by gender and age. We divided the age group in to three groups which ranged from 20 to 34 years old, from 35 to 49 years old, and lastly from 50 to 64 years old. And then we collected blood samples after 15 min, 30 min, 1 hr, 2 hr, 3 hr, 4 hr, 5 hr and 15 hr of after drinking to measure the blood acetaldehyde concentration. Results In ALDH2 1*2 allele group, there are significant differences of the blood acetaldehyde concentration between the age groups. In ALDH2 1*2 allele and male group, there are significant differences of the blood acetaldehyde concentration between the age groups. Conclusions There are significant differences of the blood acetaldehyde concentration between the age groups according to ALDH2 genotype. Also, there are significant differences of the blood acetaldehyde concentration between the age groups with male gender and ALDH2 1*2 allele. Studies about other factors that may influence the blood acetaldehyde concentration are needed.

키워드

과제정보

This research was supported by a fund (HD16A1569) by Research of Korea Centers for Disease Control and Prevention.

참고문헌

  1. Zakhari S. Overview: how is alcohol metabolized by the body? Alcohol Res Health 2006;29:245-254. https://doi.org/10.1159/000095013
  2. Quertemont E, Didone V. Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol. Alcohol Res Health 2006;29:258-265.
  3. Eriksson CJ. The role of acetaldehyde in the actions of alcohol (update 2000). Alcohol Clin Exp Res 2001;25(Suppl 1):15S-32S. https://doi.org/10.1111/j.1530-0277.2001.tb02369.x
  4. Quertemont E, Tambour S, Tirelli E. The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies. Prog Neurobiol 2005;75:247-274. https://doi.org/10.1016/j.pneurobio.2005.03.003
  5. Quertemont E, Tambour S, Bernaerts P, Zimatkin SM, Tirelli E. Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects. Psychopharmacology (Berl) 2004;177:84-92. https://doi.org/10.1007/s00213-004-1911-x
  6. Brown ZW, Amit Z, Rockman GE. Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats. Psychopharmacology (Berl) 1979;64:271-276. https://doi.org/10.1007/BF00427509
  7. Rodd-Henricks ZA, Melendez RI, Zaffaroni A, Goldstein A, McBride WJ, Li TK. The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats. Pharmacol Biochem Behav 2002;72:55-64. https://doi.org/10.1016/S0091-3057(01)00733-X
  8. Belluzzi JD, Wang R, Leslie FM. Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats. Neuropsychopharmacology 2005;30:705-712. https://doi.org/10.1038/sj.npp.1300586
  9. Foddai M, Dosia G, Spiga S, Diana M. Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology 2004;29:530-536. https://doi.org/10.1038/sj.npp.1300326
  10. Peng GS, Yin SJ. Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. Hum Genomics 2009;3:121.
  11. Goedde HW, Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G, et al. Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet 1992;88:344-346. https://doi.org/10.1007/BF00197271
  12. Mizoi Y, Tatsuno Y, Adachi J, Kogame M, Fukunaga T, Fujiwara S, et al. Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese. Pharmacol Biochem Behav 1983;18(Suppl 1):127-133. https://doi.org/10.1016/0091-3057(83)90159-4
  13. Wall TL, Shea SH, Chan KK, Carr LG. A genetic association with the development of alcohol and other substance use behavior in Asian Americans. J Abnorm Psychol 2001;110:173-178. https://doi.org/10.1037/0021-843X.110.1.173
  14. Li TK, Yin SJ, Crabb DW, O'Connor S, Ramchandani VA. Genetic and environmental influences on alcohol metabolism in humans. Alcohol Clin Exp Res 2001;25:136-144. https://doi.org/10.1111/j.1530-0277.2001.tb02138.x
  15. Kang TS, Woo SW, Park HJ, Lee Y, Roh J. Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups. J Clin Pharm Ther 2009;34:225-230.
  16. Enomoto N, Takase S, Yasuhara M, Takada A. Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 1991;15:141-144. https://doi.org/10.1111/j.1530-0277.1991.tb00532.x
  17. Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Mizukami T, et al. Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. Alcohol Clin Exp Res 2008;32:1607-1614. https://doi.org/10.1111/j.1530-0277.2008.00739.x
  18. Collins AC, Yeager TN, Lebsack ME, Panter SS. Variations in alcohol metabolism: influence of sex and age. Pharmacol Biochem Behav 1975;3:973-978. https://doi.org/10.1016/0091-3057(75)90004-0
  19. Meier P, Seitz HK. Age, alcohol metabolism and liver disease. Curr Opin Clin Nutr Metab Care 2008;11:21-26. https://doi.org/10.1097/MCO.0b013e3282f30564
  20. Matsuda T, Yabushita H, Kanaly RA, Shibutani S, Yokoyama A. Increased DNA damage in ALDH2-deficient alcoholics. Chem Res Toxicol 2006;19:1374-1378. https://doi.org/10.1021/tx060113h
  21. Hashimoto T, Uchida K, Okayama N, Imate Y, Suehiro Y, Ueyama Y, et al. ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma. Tumour Biol 2006;27:334-338. https://doi.org/10.1159/000096126
  22. Shin CM, Kim N, Cho SI, Kim JS, Jung HC, Song IS. Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population. Int J Epidemiol 2011;40:1047-1055. https://doi.org/10.1093/ije/dyr067
  23. Kimura M, Miyakawa T, Matsushita S, So M, Higuchi S. Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism. Alcohol Clin Exp Res 2011;35:1923-1927. https://doi.org/10.1111/j.1530-0277.2011.01543.x
  24. Kishimoto R, Ogishi Y, Ueda M, Matsusaki M, Amako K, Goda K, et al. Gender-related differences in mouse hepatic ethanol metabolism. J Nutr Sci Vitaminol (Tokyo) 2002;48:216-224. https://doi.org/10.3177/jnsv.48.216
  25. Mumenthaler MS, Taylor JL, O'Hara R, Yesavage JA. Gender differences in moderate drinking effects. Alcohol Res Health 1999;23:55-64.
  26. Zeiner AR, Kegg PS, Blackburn M, Stratton R. Gender differences in peak acetaldehyde concentration after an acute dose of ethanol. Neurobehav Toxicol Teratol 1983;5:201-204.