Acknowledgement
This work was supported by the Anhui Medical University Foundation (2020xkj217).
References
- Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R. 2020. Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int. J. Mol. Sci. 21: 4012.
- Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. 2020. Gastric cancer. Lancet 396: 635-648.
- Cerrato-Izaguirre D, Chirino YI, Garcia-Cuellar CM, Santibanez-Andrade M, Prada D, Hernandez-Guerrero A, et al. 2022. Mutational landscape of gastric adenocarcinoma in Latin America: a genetic approach for precision medicine. Genes Dis. 9: 928-940.
- Hoshi H. 2020. Management of gastric adenocarcinoma for general surgeons. Surg. Clin. North Am. 100: 523-534.
- Ajani JA, Lee J, Sano T, Janjigian YY, Fan D, Song S. 2017. Gastric adenocarcinoma. Nat. Rev. Dis. Primers 3: 17036.
- Sun X, Diao X, Zhu X, Yin X, Cheng G. 2021. Nanog-mediated stem cell properties are critical for MBNL3-associated paclitaxel resistance of ovarian cancer. J. Biochem. 169: 747-756.
- Oladimeji PO, Bakke J, Wright WC, Chen T. 2020. KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion. Sci. Rep. 10: 1485.
- Yu Z, Wang G, Zhang C, Liu Y, Chen W, Wang H, et al. 2020. LncRNA SBF2-AS1 affects the radiosensitivity of non-small cell lung cancer via modulating microRNA-302a/MBNL3 axis. Cell Cycle 19: 300-316.
- Yuan JH, Liu XN, Wang TT, Pan W, Tao QF, Zhou WP, et al. 2017. The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1. Nat. Cell Biol. 19: 820-832.
- Revathidevi S, Munirajan AK. 2019. Akt in cancer: mediator and more. Semin. Cancer Biol. 59: 80-91.
- Xu Z, Han X, Ou D, Liu T, Li Z, Jiang G, et al. 2020. Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy. Appl. Microbiol. Biotechnol. 104: 575-587.
- Baghery Saghchy Khorasani A, Pourbagheri-Sigaroodi A, Pirsalehi A, Safaroghli-Azar A, Zali MR, Bashash D. 2021. The PI3K/Akt/mTOR signaling pathway in gastric cancer; from oncogenic variations to the possibilities for pharmacologic interventions. Eur. J. Pharmacol. 898: 173983.
- Fattahi S, Amjadi-Moheb F, Tabaripour R, Ashrafi GH, Akhavan-Niaki H. 2020. PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond. Life Sci. 262: 118513.
- Viallard C, Larrivee B. 2017. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. Angiogenesis 20: 409-426.
- Olejarz W, Kubiak-Tomaszewska G, Chrzanowska A, Lorenc T. 2020. Exosomes in angiogenesis and anti-angiogenic therapy in cancers. Int. J. Mol. Sci. 21: 5840.
- Zhang S, Zhang R, Xu R, Shang J, He H, Yang Q. 2020. MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3). Gene 733: 144383.
- Chen JJ, Ren YL, Shu CJ, Zhang Y, Chen MJ, Xu J, et al. 2020. JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis. J. Exp. Clin. Cancer Res. 39: 118.
- Lv WL, Hu YY, Li ZN, Zhang W, Pan Q. 2020. PAX3 silencing suppresses gastric cancer proliferation and angiogenesis via MET/PI3K signaling. Neoplasma 67: 304-311.
- Han X, Liu H, Tang X, Zhao Y. 2022. Knockdown of mediator complex subunit 27 suppresses gastric cancer cell metastasis and angiogenesis via Wnt/β-catenin pathway. Tissue Cell 79: 101973.
- Zhu H, Wu Y, Kang M, Zhang B. 2020. MiR-877 suppresses gastric cancer progression by downregulating AQP3. J. Int. Med. Res. 48: 300060520903661.
- Liu H, Chen K, Wang L, Zeng X, Huang Z, Li M, et al. 2019. miR-613 inhibits Warburg effect in gastric cancer by targeting PFKFB2. Biochem. Biophys. Res. Commun. 515: 37-43.
- Zhang H, Li L, Yuan C, Wang C, Gao T, Zheng Z. 2020. MiR-489 inhibited the development of gastric cancer via regulating HDAC7 and PI3K/AKT pathway. World J. Surg. Oncol. 18: 73.
- Xie Y, Liu X, Hu T, Wang W. 2020. miR-302e suppresses glioma progression by targeting VEGFA. Cancer Manag. Res. 12: 10965-10974.
- Li D, Jiang X, Zhang X, Cao G, Wang D, Chen Z. 2019. Long noncoding RNA FGD5-AS1 promotes colorectal cancer cell proliferation, migration, and invasion through upregulating CDCA7 via sponging miR-302e. In Vitro Cell. Dev. Biol. Anim. 55: 577-585.
- Chen B, Song L, Nie X, Lin F, Yu Z, Kong W, et al. 2020. CXCL1 regulated by miR-302e is involved in cell viability and motility of colorectal cancer via inhibiting JAK-STAT signaling pathway. Front. Oncol. 10: 577229.
- Wu S, Chen M, Huang J, Zhang F, Lv Z, Jia Y, et al. 2021. ORAI2 promotes gastric cancer tumorigenicity and metastasis through PI3K/Akt signaling and MAPK-dependent focal adhesion disassembly. Cancer Res. 81: 986-1000.
- Zhang H, Pan YZ, Cheung M, Cao M, Yu C, Chen L, et al. 2019. LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway. Cell Death Dis. 10: 230.
- Zhang J, Lv W, Liu Y, Fu W, Chen B, Ma Q, et al. 2021. Nucleoporin 37 promotes the cell proliferation, migration, and invasion of gastric cancer through activating the PI3K/AKT/mTOR signaling pathway. In Vitro Cell. Dev. Biol. Anim. 57: 987-997.