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Flow diverter stenting for intracranial aneurysms in the pediatric population: Two case reports and literature review

  • Akram M Eraky (Department of Neurosurgery, Medical College of Wisconsin) ;
  • Christina Feller (Department of Neurosurgery, Medical College of Wisconsin) ;
  • Hatem Tolba (Department of Neurology, Medical College of Wisconsin) ;
  • Mokshal Porwal (Department of Neurosurgery, Medical College of Wisconsin) ;
  • Raphael H. Sacho (Department of Neurosurgery, Northwell Health) ;
  • Hirad Hedayat (Department of Neurosurgery, Medical College of Wisconsin)
  • Received : 2023.04.14
  • Accepted : 2023.07.12
  • Published : 2024.03.31

Abstract

The Pipeline Embolization Device (PED) is a flow-diverting intraluminal device that is approved for use in adults 18 years or older with internal carotid artery aneurysms. However, it can also be used off-label in pediatric patients with aneurysms that cannot be resolved with traditional endovascular treatments. Herein, we present two cases of flow diversion in the pediatric population with complete obliteration of the aneurysm and excellent outcomes. Flow diversion has been shown to be a safe endovascular option in treating complex aneurysms in children. Larger-sized, multicenter trials are encouraged to compare outcomes between flow diversion and other aneurysm treatment options given the rarity of pediatric aneurysms.

Keywords

References

  1. Abla AA, Zaidi HA, Crowley RW, Britz GW, McDougall CG, Albuquerque FC, et al. Optic chiasm compression from mass effect and thrombus formation following unsuccessful treatment of a giant supraclinoid ICA aneurysm with the Pipeline device: Open surgical bailout with STA-MCA bypass and parent vessel occlusion. J Neurosurg Pediatr. 2014 Jul;14(1):31-7. https://doi.org/10.3171/2014.4.PEDS13213
  2. Adeeb N, Griessenauer CJ, Foreman PM, Moore JM, Shallwani H, Motiei-Langroudi R, et al. Use of platelet function testing before pipeline embolization device placement: A multicenter cohort study. Stroke. 2017 May;48(5):1322-30. https://doi.org/10.1161/STROKEAHA.116.015308
  3. Appelboom G, Kadri K, Hassan F, Leclerc X. Infectious aneurysm of the cavernous carotid artery in a child treated with a new-generation of flow-diverting stent graft: Case report. Neurosurgery. 2010 Mar;66(3):e623-4; discussion e624.
  4. Ares WJ, Tonetti DA, Greene S, Sharma MS, Xavier F, Jankowitz BT, et al. Pipeline embolization of an infectious basilar artery aneurysm in a 2-year-old child: Case report, discussion of the literature and perioperative considerations. Oper Neurosurg (Hagerstown). 2019 Nov;17(5):e224-8. https://doi.org/10.1093/ons/opz002
  5. Barburoglu M, Arat A. Flow diverters in the treatment of pediatric cerebrovascular diseases. AJNR Am J Neuroradiol. 2017 Jan;38(1):113-8. https://doi.org/10.3174/ajnr.A4959
  6. Burrows AM, Zipfel G, Lanzino G. Treatment of a pediatric recurrent fusiform middle cerebral artery (MCA) aneurysm with a flow diverter. J Neurointerv Surg. 2013 Nov;5(6):e47.
  7. Cherian J, Srinivasan V, Froehler MT, Grossberg JA, Cawley CM, Hanel RA, et al. Flow diversion for treatment of intracranial aneurysms in pediatric patients: Multicenter case series. Neurosurgery. 2020 Jul;87(1):53-62. https://doi.org/10.1093/neuros/nyz380
  8. Cinar C, Bozkaya H, Oran I. Endovascular treatment of cranial aneurysms with the pipeline flow diverting stent: Preliminary midterm results. Diagn Interv Radiol. 2013 MarApr;19(2):154-64. https://doi.org/10.4261/1305-3825.DIR.6111-12.1
  9. Cobb MIH, Zomorodi AR, Hauck EF, Smith TP, Fernando Gonzalez L. Optimal pediatric dosing of anti-platelet agents for pipeline stent embolization: A case report and review of the literature. Childs Nerv Syst. 2017 Apr;33(4):685-90. https://doi.org/10.1007/s00381-016-3311-z
  10. Colby GP, Jiang B, Bender MT, Beaty NB, Westbroek EM, Xu R, et al. Pipeline-assisted coil embolization of a large middle cerebral artery pseudoaneurysm in a 9-month-old infant: Experience from the youngest flow diversion case. J Neurosurg Pediatr. 2018 Nov;22(5):532-40. https://doi.org/10.3171/2018.6.PEDS18165
  11. Crowley RW, Evans AJ, Kassell NF, Jensen ME, Dumont AS. Endovascular treatment of a fusiform basilar artery aneurysm using multiple "in-stent stents": Technical note. J Neurosurg Pediatr. 2009 Jun;3(6):496-500. https://doi.org/10.3171/2009.2.PEDS08468
  12. Cunegatto-Braga M, Hogan B, Aguilar-Salinas P, Beier AD, Hanel RA. Pipeline embolization device flow diversion for a dissecting ruptured posterior cerebral artery aneurysm in a pediatric patient. World Neurosurg. 2018 Sep;117:255-60. https://doi.org/10.1016/j.wneu.2018.06.031
  13. de Barros Faria M, Castro RN, Lundquist J, Scrivano E, Ceratto R, Ferrario A, et al. The role of the pipeline embolization device for the treatment of dissecting intracranial aneurysms. AJNR Am J Neuroradiol. 2011 Dec;32(11):2192-5. https://doi.org/10.3174/ajnr.A2671
  14. Eddleman CS, Surdell D, DiPatri A, Tomita T, Shaibani A. Infectious intracranial aneurysms in the pediatric population: Endovascular treatment with Onyx. Childs Nerv Syst. 2008 Aug;24(8):909-15. https://doi.org/10.1007/s00381-008-0614-8
  15. Ghali MGZ, Srinivasan VM, Cherian J, Wagner KM, Chen SR, Johnson J, et al. Multimodal treatment of intracranial aneurysms in children: Clinical case series and review of the literature. World Neurosurg. 2018 Mar;111:e294-307. https://doi.org/10.1016/j.wneu.2017.12.057
  16. Ikeda DS, Marlin ES, Shaw A, Powers CJ. Successful endovascular reconstruction of a recurrent giant middle cerebral artery aneurysm with multiple telescoping flow diverters in a pediatric patient. Pediatr Neurosurg. 2015;50(2):88-93. https://doi.org/10.1159/000375167
  17. Jia L, Wang J, Zhang L, Zhang Y, You W, Yang X, et al. Pediatric patient with a giant vertebrobasilar dissecting aneurysm successfully treated with three pipeline embolization devices. Front Neurol. 2020 Jul;11:633.
  18. Kalani MY, Elhadi AM, Ramey W, Nakaji P, Albuquerque FC, McDougall CG, et al. Revascularization and pediatric aneurysm surgery. J Neurosurg Pediatr. 2014 Jun;13(6):641-6. https://doi.org/10.3171/2014.3.PEDS13444
  19. Kan P, Mokin M, Puri AS, Wakhloo AK. Successful treatment of a giant pediatric fusiform basilar trunk aneurysm with surpass flow diverter. J Neurointerv Surg. 2016 Jun;8(6):e23.
  20. Kim M, Lee HS, Lee S, Park JC, Ahn JS, Kwon DH, et al. Pediatric intracranial aneurysms: Favorable outcomes despite rareness and complexity. World Neurosurg. 2019 May;125:e1203-16. https://doi.org/10.1016/j.wneu.2019.01.280
  21. Krings T, Geibprasert S, terBrugge KG. Pathomechanisms and treatment of pediatric aneurysms. Childs Nerv Syst. 2010 Oct;26(10):1309-18. https://doi.org/10.1007/s00381-009-1054-9
  22. Kumaria A, McConachie NS, Macarthur DC. Successful treatment of giant cavernous carotid artery aneurysm in a child using a flow diverter stent. Br J Neurosurg. 2021 Feb;35(1):122-4. https://doi.org/10.1080/02688697.2018.1518517
  23. Li JS, Yow E, Berezny KY, Bokesch PM, Takahashi M, Graham TP, et al. Dosing of clopidogrel for platelet inhibition in infants and young children: Primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial. Circulation. 2008 Jan;117(4):553-9. https://doi.org/10.1161/CIRCULATIONAHA.107.715821
  24. Lin N, Lanzino G, Lopes DK, Arthur AS, Ogilvy CS, Ecker RD, et al. Treatment of distal anterior circulation aneurysms with the pipeline embolization device: A US multicenter experience. Neurosurgery. 2016 Jul;79(1):14-22. https://doi.org/10.1227/NEU.0000000000001117
  25. Lubicz B, Collignon L, Raphaeli G, Pruvo JP, Bruneau M, De Witte O, et al. Flow-diverter stent for the endovascular treatment of intracranial aneurysms: A prospective study in 29 patients with 34 aneurysms. Stroke. 2010 Oct;41(10):2247-53. https://doi.org/10.1161/STROKEAHA.110.589911
  26. Mohammad LM, Coon AL, Carlson AP. Resolution of giant basilar artery aneurysm compression and reversal of sensorineural hearing loss with use of a flow diverter: Case report. J Neurosurg Pediatr. 2017 Jul;20(1):81-5. https://doi.org/10.3171/2016.9.PEDS16428
  27. Navarro R, Brown BL, Beier A, Ranalli N, Aldana P, Hanel RA. Flow diversion for complex intracranial aneurysms in young children. J Neurosurg Pediatr. 2015 Mar;15(3):276-81. https://doi.org/10.3171/2014.9.PEDS14333
  28. Peters PJ, Harrison T, Lennox JL. A dangerous dilemma: Management of infectious intracranial aneurysms complicating endocarditis. Lancet Infect Dis. 2006 Nov;6(11):742-8. https://doi.org/10.1016/S1473-3099(06)70631-4
  29. Samples DC, Ravindra VM, Thoms DJ, Tarasiewicz I, Grandhi R. Successful flow diversion treatment of ruptured infectious middle cerebral artery aneurysms with the use of Pipeline Flex with Shield technology. Interv Neuroradiol. 2021 Apr;27(2):225-9. https://doi.org/10.1177/1591019921990506
  30. Saraf R, Shrivastava M, Siddhartha W, Limaye U. Intracranial pediatric aneurysms: Endovascular treatment and its outcome. J Neurosurg Pediatr. 2012 Sep;10(3):230-40. https://doi.org/10.3171/2012.5.PEDS1210
  31. Sastry RA, Koch MJ, Grannan BL, Stapleton CJ, Butler WE, Patel AB. Flow diversion of a recurrent, iatrogenic basilar tip aneurysm in a pediatric patient: Case report. J Neurosurg Pediatr. 2018 Jan;21(1):90-3. https://doi.org/10.3171/2017.7.PEDS17235
  32. Takemoto K, Tateshima S, Golshan A, Gonzalez N, Jahan R, Duckwiler G, et al. Endovascular treatment of pediatric intracranial aneurysms: a retrospective study of 35 aneurysms. J Neurointerv Surg. 2014 Jul;6(6):432-8. https://doi.org/10.1136/neurintsurg-2013-010852
  33. Tonetti DA, Casillo SM, Jankowitz BT. Telescoping flow diverters for a pediatric fusiform distal anterior cerebral artery aneurysm: Technical case report. Childs Nerv Syst. 2021 Mar; 37(3):999-1002. https://doi.org/10.1007/s00381-020-04797-y
  34. Trivelato FP, Rezende MTS, Fonseca LV, Bonadio LE, Ulhoa AC, Abud DG. Pipeline embolization device for the treatment of a traumatic intracranial aneurysm in a child. Childs Nerv Syst. 2017 May;33(5):869-72. https://doi.org/10.1007/s00381-016-3334-5
  35. Vachhani JA, Nickele CM, Elijovich L, Klimo P, Arthur AS. Flow diversion for treatment of growing A2 aneurysm in a child: Case report and review of flow diversion for intracranial aneurysms in pediatric patients. World Neurosurg. 2016 Dec;96:607.e13-607.e17. https://doi.org/10.1016/j.wneu.2016.09.078
  36. Vargas SA, Diaz C, Herrera DA, Dublin AB. Intracranial aneurysms in children: The role of stenting and flow-diversion. J Neuroimaging. 2016 Jan-Feb;26(1):41-5. https://doi.org/10.1111/jon.12305
  37. Zarzecka A, Gory B, Turjman F. Implantation of two flow diverter devices in a child with a giant, fusiform vertebral artery aneurysm: Case report. Pediatr Neurol. 2014 Feb;50(2):185-7. https://doi.org/10.1016/j.pediatrneurol.2013.09.014