The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Metformin and tuberculosis: extraordinary stories of ordinary co-prevalent patients

  • Won-Il Choi (Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine)
  • Received : 2024.01.31
  • Accepted : 2024.02.20
  • Published : 2024.03.01
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References

  1. Raviglione MC, Snider DE Jr, Kochi A. Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic. JAMA 1995;273:220-226.  https://doi.org/10.1001/jama.1995.03520270054031
  2. Lee EH, Lee JM, Kang YA, et al. Prevalence and impact of diabetes mellitus among patients with active pulmonary tuberculosis in South Korea. Lung 2017;195:209-215.  https://doi.org/10.1007/s00408-017-9978-4
  3. Noubiap JJ, Nansseu JR, Nyaga UF, et al. Global prevalence of diabetes in active tuberculosis: a systematic review and meta-analysis of data from 2.3 million patients with tuberculosis. Lancet Glob Health 2019;7:e448-e460.  https://doi.org/10.1016/S2214-109X(18)30487-X
  4. Caceres G, Calderon R, Ugarte-Gil C. Tuberculosis and comorbidities: treatment challenges in patients with comorbid diabetes mellitus and depression. Ther Adv Infect Dis 2022;9:20499361221095831. 
  5. Naicker N, Sigal A, Naidoo K. Metformin as host-directed therapy for TB treatment: scoping review. Front Microbiol 2020;11:435. 
  6. Chung E, Jeong D, Mok J, et al. Relationship between metformin use and mortality in tuberculosis patients with diabetes: a nationwide cohort study. Korean J Intern Med 2024 Feb 6 [Epub]. DOI: 10.3904/kjim.2023.303. 
  7. Faurholt-Jepsen D, Range N, PrayGod G, et al. Diabetes is a strong predictor of mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients from Mwanza, Tanzania. Trop Med Int Health 2013;18:822-829.  https://doi.org/10.1111/tmi.12120
  8. Baker MA, Harries AD, Jeon CY, et al. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med 2011;9:81. 
  9. Sutter A, Landis D, Nugent K. The potential role for metformin in the prevention and treatment of tuberculosis. J Thorac Dis 2022;14:1758-1765.  https://doi.org/10.21037/jtd-22-39
  10. Ma Y, Pang Y, Shu W, et al. Metformin reduces the relapse rate of tuberculosis patients with diabetes mellitus: experiences from 3-year follow-up. Eur J Clin Microbiol Infect Dis 2018;37:1259-1263.  https://doi.org/10.1007/s10096-018-3242-6
  11. Bohme J, Martinez N, Li S, et al. Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits. Nat Commun 2020;11:5225.