DOI QR코드

DOI QR Code

Secondary Breast Burkitt Lymphoma Involving the Stomach, Ovary, Pancreas, and Bones: A Case Report

전신의 다발성 침범을 동반한 이차성 유방 버킷 림프종: 증례 보고

  • Hyun Ji Lee (Department of Radiology, Busan Paik Hospital, Inje University College of Medicine) ;
  • Gi Won Shin (Department of Radiology, Busan Paik Hospital, Inje University College of Medicine) ;
  • Young Mi Park (Department of Radiology, Busan Paik Hospital, Inje University College of Medicine) ;
  • Minji Shin (Department of Radiology, Busan Paik Hospital, Inje University College of Medicine) ;
  • Jin Hee Park (Department of Radiology, Busan Paik Hospital, Inje University College of Medicine) ;
  • Ha Young Park (Department of Pathology, Busan Paik Hospital, Inje University College of Medicine)
  • 이현지 (인제대학교 의과대학 부산백병원 영상의학과) ;
  • 신기원 (인제대학교 의과대학 부산백병원 영상의학과) ;
  • 박영미 (인제대학교 의과대학 부산백병원 영상의학과) ;
  • 신민지 (인제대학교 의과대학 부산백병원 영상의학과) ;
  • 박진희 (인제대학교 의과대학 부산백병원 영상의학과) ;
  • 박하영 (인제대학교 의과대학 부산백병원 병리과)
  • Received : 2023.01.18
  • Accepted : 2024.01.07
  • Published : 2024.07.01

Abstract

Breast lymphomas are rare, malignant breast neoplasms with a heterogeneous pattern of clinical symptoms. Burkitt's lymphoma is a rare, highly aggressive, and rapidly growing B-cell non-Hodgkin lymphoma. We report about a 27-year-old woman diagnosed as having secondary breast Burkitt's lymphoma, probably originating from the stomach, with multiple distant metastases. Breast ultrasonography revealed multiple, variable sized, heterogeneous masses with posterior acoustic enhancement and echogenic rims. These imaging findings may sometimes overlap with those of other breast malignancies. However, unlike other breast malignancies, lymphoma can be diagnosed by biopsy and does not require surgical excision. To avoid unnecessary treatment, radiologists and clinicians should be aware of the characteristic imaging features of breast lymphomas.

유방 림프종은 희귀한 유방 악성 종양으로 임상 증상과 경과가 이질적인 패턴을 보인다. 그 중 버킷 림프종은 매우 드물고, 공격적이며 빠르게 성장하는 B세포 비호지킨 림프종이다. 우리는 위에서 시작된 것으로 추정되고, 여러 부위의 전이를 동반한 이차성 유방 버킷 림프종으로 진단받은 27세 여성의 사례를 보고한다. 유방 초음파상에서 후방 음영 증가와 에코성 띠를 포함한 다양한 크기의 비균질한 병변으로 관찰되었다. 이러한 영상 소견은 종종 다른 유방의 악성 종양 소견과 혼동될 수 있다. 그러나 다른 유방 악성 종양과 달리 림프종은 생검을 통해 진단할 수 있으며 외과적 절제가 필요하지 않다. 불필요한 치료를 피하기 위해서 영상의학과 전문의와 임상의는 유방 림프종의 특징적인 영상학적 특징을 알아야 한다.

Keywords

References

  1. Raj SD, Shurafa M, Shah Z, Raj KM, Fishman MDC, Dialani VM. Primary and secondary breast lymphoma: clinical, pathologic, and multimodality imaging review. Radiographics 2019;39:610-625 https://doi.org/10.1148/rg.2019180097
  2. Shim E, Song SE, Seo BK, Kim YS, Son GS. Lymphoma affecting the breast: a pictorial review of multimodal imaging findings. J Breast Cancer 2013;16:254-265 https://doi.org/10.4048/jbc.2013.16.3.254
  3. Duncan VE, Reddy VV, Jhala NC, Chhieng DC, Jhala DN. Non-Hodgkin's lymphoma of the breast: a review of 18 primary and secondary cases. Ann Diagn Pathol 2006;10:144-148 https://doi.org/10.1016/j.anndiagpath.2005.09.018
  4. Surov A, Holzhausen HJ, Wienke A, Schmidt J, Thomssen C, Arnold D, et al. Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. Br J Radiol 2012;85:e195-e205 https://doi.org/10.1259/bjr/78413721
  5. Kalisz K, Alessandrino F, Beck R, Smith D, Kikano E, Ramaiya NH, et al. An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence. Insights Imaging 2019;10:56
  6. James ER, Miranda RN, Turner SD. Primary lymphomas of the breast: a review. JPRAS Open 2022;32:127-143 https://doi.org/10.1016/j.jpra.2022.01.004
  7. Janbabai G, Kayedimajd S, Alian S, Naghshvar F, Rashidi M, Farazmandfar T. Bilateral breast swelling in a 23-year-old woman with Burkitt lymphoma. J Res Med Sci 2012;17:1188-1191
  8. Demirkazik FB. MR imaging features of breast lymphoma. Eur J Radiol 2002;42:62-64 https://doi.org/10.1016/S0720-048X(01)00416-8
  9. Kuba MG, Giess CS, Wieczorek TJ, Lester SC. Hyperechoic malignancies of the breast: underlying pathologic features correlating with this unusual appearance on ultrasound. Breast J 2020;26:643-652 https://doi.org/10.1111/tbj.13501
  10. Kopans DB. Breast imaging. 3rd ed. Philadelphia, Lippincott Williams & Wilkins 2007:593-596