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Neutrophil Migration Is Mediated by VLA-6 in the Inflamed Adipose Tissue

  • Hyunseo Lim (Department of Anatomy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine) ;
  • Young Ho Choe (Department of Anatomy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine) ;
  • Jaeho Lee (Department of Anatomy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine) ;
  • Gi Eun Kim (Department of Anatomy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine) ;
  • Jin Won Hyun (Department of Biochemistry, Jeju Research Center for Natural Medicine, Jeju National University College of Medicine) ;
  • Young-Min Hyun (Department of Anatomy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine)
  • Received : 2024.03.04
  • Accepted : 2024.05.26
  • Published : 2024.06.30
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Abstract

Adipose tissue, well known for its endocrine function, plays an immunological role in the body. The inflamed adipose tissue under LPS-induced systemic inflammation is characterized by the dominance of pro-inflammatory immune cells, particularly neutrophils. Although migration of macrophages toward damaged or dead adipocytes to form a crown-like structure in inflamed adipose tissue has been revealed, the neutrophilic interaction with adipocytes or the extracellular matrix remains unknown. Here, we demonstrated the involvement of adhesion molecules, particularly integrin α6β1, of neutrophils in adipocytes or the extracellular matrix of inflamed adipose tissue interaction. These results suggest that disrupting the adhesion between adipose tissue components and neutrophils may govern the accumulation of excessive neutrophils in inflamed tissues, a prerequisite in developing anti-inflammatory therapeutics by inhibiting inflammatory immune cells.

Keywords

Acknowledgement

This study was supported by the faculty research grant of Yonsei University College of Medicine (6-2023-0081 to Y.M.H) and the National Research Foundation funded by the Ministry of Science and ICT (MSIT) of the Government of Korea (RS-2023-00207834 to Y.-M.H.) and the Ministry of Education (RS-2023-00270936 to J.W.H).

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