The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
권호 표지
DOI QR코드

DOI QR Code

A Systemic Review and Meta-Analysis of Herbal Medicine Treatment for Acute Pharyngitis : Based on Chinese Articles

급성인두염의 한약 치료에 대한 체계적 문헌 고찰 및 메타분석 : 중국 논문을 중심으로

  • Young-Eun Lee (Dep. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Daegu Hanny University) ;
  • Ji-One Im (Dep. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Daegu Hanny University) ;
  • Ji-Young Choi (Dep. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Daegu Hanny University) ;
  • Seon-Young Jee (Dep. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Daegu Hanny University) ;
  • Min Hwangbo (Dep. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Daegu Hanny University)
  • 이영은 (대구한의대 한방병원 안이비인후피부과) ;
  • 임지원 (대구한의대 한방병원 안이비인후피부과) ;
  • 최지영 (대구한의대 한방병원 안이비인후피부과) ;
  • 지선영 (대구한의대 포항한방병원 안이비인후피부과 ) ;
  • 황보민 (대구한의대 한방병원 안이비인후피부과)
  • Received : 2024.07.05
  • Accepted : 2024.08.01
  • Published : 2024.08.25
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study is to investigate the effectiveness and safety of herbal medicine treatment for acute pharyngitis. Methods : 2 databases(Wangfang Med Online, CNKI) were used to search Randomized Controlled Trials(RCTs) that used herbal medicine treatment for acute pharyngitis, which were published from January 2007 until April 2024. Results : 9 RCTs were selected in this study, and all studies compared herbal medicine alone treatment with western medicine alone treatment. The most frequently used medicine was Toxin-removing medicinal(淸熱解毒藥). Platycodonis Radix(桔梗) was the most frequently used herb. Meta-analysis of nine studies showed that the Total Effective Rate(TER) of treatment group was statistically higher than that of control group(RR:1.12, 95% CI:1.06 to 1.19, p<0.00001, I2=22%). Meta-analysis of 3 studies showed that the total symptom score of treatment group statistically improved than that of control group(MD: -1.00, 95% CI: -1.30 to -0.71, p<0.00001, I2=0%). Mild adverse events such as anorexia were identified in 4 RCTs, but no serious adverse events were reported. Conclusion : Using herbal medicine alone can be more effective and safe in improving acute pharyngitis than using western medicine. But further well-designed studies are needed because heterogeneity between studies existed and the quality of the reports needs to be improved.

Keywords

References

  1. The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology. Korean Medicine of Ophthalmology & Otolaryngology. Paju:Globooks. 2019:221,222. 
  2. Park MK. Otology, Rhinology and Laryngology. Seoul:Ilchogak. 1996(1):353,354. 
  3. Gerber MA. Diagnosis and Treatment of Pharyngitis in Children. Peditr. Clin North Am. 2005;52(3):729-47. 
  4. Robertson KA, Volmink JA, Mayosi BM. Antibiotics for the Primary Prevention of Acute Rheumatic Fever:a meta-analysis. BMC Cardiovasc Disord. 2005;5(1):11. 
  5. Cots JM, Alos JI, Barcena M, Boleda X, Canada JL, Gomez N, et al. Recommendations for Management of Acute Pharyngitis in Adults. Acta Otorrinolaringologica(English Edition). 2015;66(3):159-70. 
  6. Zhu S, Mao X, Liu Q. Clinical Observation on the Treatment of Acute Pharyngitis (Wind Heat Syndrome) with Shufeng Jiedu Capsule Combined with Budesonide Atomization. Zhongyiyaoyanjiu. 2019;16(8):67-71. 
  7. Mayes T, Pichichero ME. Are Follow-up Cultures Necessary when Rapid Antigen Detection Tests are Negative for Group A Streptococci. Clin Peditr. 2001;40(4):191-5. 
  8. Robert M, Kliegman MD, Joseph W, St. Geme III. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia:Elsevier. 2024:2558-62. 
  9. Kang JG. A Systematic Review on the Effectiveness of Acupuncture Treatment for Acute Pharyngitis. J Korean Med Ophthalmol Otolaryngol Dermatol. 2018;1-38. 
  10. Yin Q, Gao Y. Clinical Verification of Cheongin-tang in Treating Acute Pharyngitis. Medical Journal of Chinese People's Health. 2007;19(6):451. 
  11. Pan Z, Xu Q. Clinical Observation on Treating Acute Pharyngitis with Yukmi-tang. Guide of China Medicine. 2010;8(22):125,126. 
  12. Liu W, Tian W, Song Q. 68 Cases of Acute Pharyngitis treated with Yukmi-tang. Heibei J TCM. 2012;34(7):1003. 
  13. Jang J. Observation on the Efficacy of Eungyo-san Flavored in the Treatment of 45 Cases of Acute Pharyngitis. Yunnan Journal of Traditional Chinese Medicine. 2012;33(8):44. 
  14. Wang Y. Observation on the Clinical Efficacy of Gyoha-tang in the Treatment of Acute Pharyngitis. Chinese Medical Frontier. 2013;8(16):124,125. 
  15. Zhong W, Zeng G. Clinical Observation on 60 Cases of Acute Pharyngitis (Wind-heat Syndrome) Treated by Chaiqinliyan Decoction. China Health Care & Nutrition. 2016;2(2):329,330. 
  16. Guo X, Xie M. 33 cases of Acute Pharyngitis treated with Cheonginchisi-tang. Henan Traditional Chinese Medicine. 2017;37(6):1038-40. 
  17. Li J. Observation on the Clinical Efficacy of Cheonginhadam-tang in the Treatment of 60 cases of Acute Pharyngitis. Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine. 2017;5(28):177,178. 
  18. Zhou Y, Chen J, Wang Y, Li Z, Xie J. Therapeutic Effect of Daecheongin-tang on Acute Pharyngitis of Exogenous Wind-heat Type. Traditional Chinese Medicine. 2019;17:104,105. 
  19. Roh SS. Kyojeong Wonsek Otolaryngology. Seoul:Iljoongsa. 1999:47. 
  20. Goossens H, Ferech M, Stichele RV, Elseviers M. Outpatient antibiotic use in Europe and association with resistance: Across-national database study. Lancet. 2005;365(9459):579-87. 
  21. Duin DV, Paterson DL. Multidrug-resistant bacteria in the community: an update. Infectious Disease Clinics. 2020;34(4):709-22. 
  22. Martens E, Demain AL. The antibiotic resistance crisis, with a focus on the United States. The Journal of antibiotics. 2017;70(5):520-6. 
  23. Larson E. Community factors in the development of antibiotic resistance. Annu. Rev. Public Health. 2007;28:435-47. 
  24. Kim IR, Kim HC, Kuk YB, Park SJ, Park YG, Park JH, et al. Bonchohak. 3rd ed. Seoul:Young Lim Publishing Co. 2011:158,178,180,242,243,497,498,545,585. 
  25. Han EH, Park JH, Kim JY, Chung YC, Jeong HG. Inhibitory mechanism of saponins deri ved from roots of Platycodon grandiflorum on anaphylactic reaction and IgE-mediated allergic response in mast cells. Food Chem Toxicol. 2009;47(6):1069-75. 
  26. Ryu J, Lee HJ, Park SH, Kim J, Lee D, Lee SK, et al. Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3) and deapi-platycodin on production and secretion of air way mucin in vitro. Phytomedicine. 2014;21(4):529-33. 
  27. Gao Q, Yang M, Zuo Z. Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L. Acta Pharmacol Sin. 2018;39(5):787-801. 
  28. Choi DH, Seung OT, Lim MH. Comparative study of the biological activities effect of Mentha arvensis L. extracts from water and 80% ethanol. Journal of the Korean Applied Science and Technology. 2019;36(1):208-16. 
  29. Kang HS, Lee JY, Kim CJ. Anti-inflammatory activity of arctigenin from Forsythiae Fructus. J Ethnopharmacol. 2008;116(2):305-12.