Clinical Endoscopy

The Korean Society of Gastrointestinal Endoscopy (대한소화기내시경학회)
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Systematic review of self-assembling peptides as topical agents for treatment and prevention of gastrointestinal bleeding

  • Andrei Voiosu (Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy) ;
  • Monica State (Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy) ;
  • Victor Dragan (Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy) ;
  • Sergiu Vaduva (Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy) ;
  • Paul Balanescu (Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy) ;
  • Radu Bogdan Mateescu (Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy) ;
  • Theodor Voiosu (Gastroenterology Department, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy)
  • Received : 2023.07.04
  • Accepted : 2023.09.30
  • Published : 2024.07.30
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Abstract

Background/Aims: Gastrointestinal bleeding is a significant and potentially lethal event. We aimed to review the efficiency and safety of self-assembling peptides for the treatment and prevention of gastrointestinal tract bleeding. Methods: We conducted a systematic search for studies describing the endoscopic use of self-assembling peptides for treatment or prevention of bleeding in the gastrointestinal tract in a parallel, independent fashion. The primary outcomes were rates of successful initial hemostasis, delayed bleeding, and rebleeding. The secondary outcomes were adverse events and ease and volume of gel used. Results: Seventeen studies were analyzed. Overall success rate of self-assembling peptides in gastrointestinal bleeding was 87.7% (38%-100%), regardless of etiology or associated treatments. Rebleeding rate ranged from 0% to 16.2%, with a mean of 4.7%, and overall delayed bleeding rate was 5% (range, 0%-15.9%). Only three adverse events were reported in a pooled number of 815 patients. The volume of gel used varied (0.43 to 3.7 mL) according to indication and type of bleeding. Conclusions: The limited available data on the use of self-assembling peptides in gastrointestinal endoscopy suggest a high efficiency and good safety profile.

Keywords

References

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