Clinical Endoscopy

The Korean Society of Gastrointestinal Endoscopy (대한소화기내시경학회)
권호 표지
DOI QR코드

DOI QR Code

Clinical meaning of sarcopenia in patients undergoing endoscopic treatment

  • Hiroyuki Hisada (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Yosuke Tsuji (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Hikaru Kuribara (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Ryohei Miyata (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Kaori Oshio (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Satoru Mizutani (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Hideki Nakagawa (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Rina Cho (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Nobuyuki Sakuma (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Yuko Miura (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Hiroya Mizutani (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Daisuke Ohki (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Seiichi Yakabi (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Yu Takahashi (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Yoshiki Sakaguchi (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Naomi Kakushima (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Nobutake Yamamichi (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo) ;
  • Mitsuhiro Fujishiro (Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo)
  • Received : 2023.07.26
  • Accepted : 2023.08.18
  • Published : 2024.07.30
Download PDF
⟨ Previous Next ⟩

Abstract

With increasing global life expectancy, the significance of geriatric assessment parameters has increased. Sarcopenia is a crucial assessment parameter and is defined as the age-related loss of muscle mass and strength. Sarcopenia is widely acknowledged as a risk factor for postoperative complications in diverse advanced malignancies and has a detrimental effect on the long-term prognosis. While most studies have primarily concentrated on the correlation between sarcopenia and advanced cancer, more recent investigations have focused on the relationship between sarcopenia and early-stage cancer. Endoscopic submucosal dissection (ESD), which is less invasive than surgical intervention, is extensively employed in the management of early-stage cancer, although it is associated with complications such as bleeding and perforation. In recent years, several reports have revealed the adverse consequences of sarcopenia in patients with early-stage cancer undergoing ESD. This literature review briefly summarizes the recent studies on the association between sarcopenia and ESD.

Keywords

References

  1. Population Division, United Nations. World Population Prospects 2022: summary of results. Population Division, United Nations; 2022.
  2. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019;48:16-31.
  3. Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 2020;21:300-307.
  4. Yang Z, Zhou X, Ma B, et al. Predictive value of preoperative sarcopenia in patients with gastric cancer: a meta-analysis and systematic review. J Gastrointest Surg 2018;22:1890-1902.
  5. O'Connell RM, O'Neill M, O Riordain MG, et al. Sarcopaenia, obesity, sarcopaenic obesity and outcomes following hepatic resection for colorectal liver metastases: a systematic review and meta-analysis. HPB (Oxford) 2022;24:1844-1853.
  6. Fang P, Zhou J, Xiao X, et al. The prognostic value of sarcopenia in oesophageal cancer: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2023;14:3-16.
  7. Fukuda Y, Yamamoto K, Hirao M, et al. Sarcopenia is associated with severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy. Gastric Cancer 2016;19:986-993.
  8. Thormann M, Omari J, Pech M, et al. Low skeletal muscle mass and post-operative complications after surgery for liver malignancies: a meta-analysis. Langenbecks Arch Surg 2022;407:1369-1379.
  9. Cleasby ME, Jamieson PM, Atherton PJ. Insulin resistance and sarcopenia: mechanistic links between common co-morbidities. J Endocrinol 2016;229:R67-R81.
  10. Tsuji M, Kakuda N, Bujo C, et al. Sarcopenia and risk of infection in adult heart transplant recipients in Japan. ESC Heart Fail 2022;9:1413-1423.
  11. Braun S, Bitton-Worms K, LeRoith D. The link between the metabolic syndrome and cancer. Int J Biol Sci 2011;7:1003-1015.
  12. Yamamoto K, Nagatsuma Y, Fukuda Y, et al. Effectiveness of a preoperative exercise and nutritional support program for elderly sarcopenic patients with gastric cancer. Gastric Cancer 2017;20:913-918.
  13. Hisada H, Sakaguchi Y, Oshio K, et al. Endoscopic treatment of superficial gastric cancer: present status and future. Curr Oncol 2022;29:4678-4688.
  14. Ono H, Yao K, Fujishiro M, et al. Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer (second edition). Dig Endosc 2021;33:4-20.
  15. Pimentel-Nunes P, Libanio D, Bastiaansen BA, et al. Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022. Endoscopy 2022;54:591-622.
  16. Tanaka S, Kashida H, Saito Y, et al. Japan Gastroenterological Endoscopy Society guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection. Dig Endosc 2020;32:219-239.
  17. Liu Q, Ding L, Qiu X, et al. Updated evaluation of endoscopic submucosal dissection versus surgery for early gastric cancer: a systematic review and meta-analysis. Int J Surg 2020;73:28-41.
  18. Nakamura F, Saito Y, Haruyama S, et al. Short-term prospective questionnaire study of early postoperative quality of life after colorectal endoscopic submucosal dissection. Dig Dis Sci 2017;62:3325-3335.
  19. Gweon TG, Yang DH. Management of complications related to colorectal endoscopic submucosal dissection. Clin Endosc 2023;56:423-432.
  20. Saito I, Tsuji Y, Sakaguchi Y, et al. Complications related to gastric endoscopic submucosal dissection and their managements. Clin Endosc 2014;47:398-403.
  21. Toya Y, Shimada T, Hamada K, et al. Prediction model of 3-year survival after endoscopic submucosal dissection for early gastric cancer in elderly patients aged≥85 years: EGC-2 model. J Cancer Res Clin Oncol 2023;149:1521-1530.
  22. Chang JW, Jung DH, Huh CW, et al. Long-term outcomes and prognostic factors of superficial esophageal cancer in patients aged ≥ 65 years. Front Med (Lausanne) 2022;8:722141.
  23. Kato M, Hayashi Y, Fukuda H, et al. Geriatric nutritional risk index as a prognostic indicator in elderly patients with early colorectal cancer undergoing endoscopic submucosal dissection. Dig Endosc 2022;34:569-578.
  24. Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr 1997;127(5 Suppl):990S-991S.
  25. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39:412-423.
  26. Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 2014;15:95-101.
  27. Falcon LJ, Harris-Love MO. Sarcopenia and the new ICD-10-CM code: screening, staging, and diagnosis considerations. Fed Pract 2017;34:24-32.
  28. Schaap LA, van Schoor NM, Lips P, et al. Associations of sarcopenia definitions, and their components, with the incidence of recurrent falling and fractures: the Longitudinal Aging Study Amsterdam. J Gerontol A Biol Sci Med Sci 2018;73:1199-1204.
  29. Hamaguchi Y, Kaido T, Okumura S, et al. Impact of skeletal muscle mass index, intramuscular adipose tissue content, and visceral to subcutaneous adipose tissue area ratio on early mortality of living donor liver transplantation. Transplantation 2017;101:565-574.
  30. Arao M, Mizutani T, Ozawa N, et al. Skeletal muscle depletion: a risk factor for pneumonia following gastric endoscopic submucosal dissection in elderly patients. Dig Dis 2021;39:435-443.
  31. Kim GH, Choi KD, Ko Y, et al. Impact of comorbidities, sarcopenia, and nutritional status on the long-term outcomes after endoscopic submucosal dissection for early gastric cancer in elderly patients aged ≥ 80 years. Cancers (Basel) 2021;13:3598.
  32. Hisada H, Tsuji Y, Obata M, et al. The impact of sarcopenia on short-and long-term outcomes of endoscopic submucosal dissection for early gastric cancer. J Gastroenterol 2022;57:952-961.
  33. Ito N, Funasaka K, Miyahara R, et al. Relationship between psoas muscle index and long-term survival in older patients aged≥80 years after endoscopic submucosal dissection for gastric cancer. Int J Clin Oncol 2022;27:729-738.
  34. Ito N, Funasaka K, Fujiyoshi T, et al. Scoring system for predicting the prognosis of elderly gastric cancer patients after endoscopic submucosal dissection. Dig Endosc 2023;35:67-76.
  35. Hisada H, Tamura N, Tsuji Y, et al. The impact of sarcopenia on adverse events associated with gastric endoscopic submucosal dissection. Surg Endosc 2022;36:6387-6395.
  36. Zhang FM, Zhang XZ, Zhu GL, et al. Impact of sarcopenia on clinical outcomes of patients with stage I gastric cancer after radical gastrectomy: a prospective cohort study. Eur J Surg Oncol 2022;48:541-547.
  37. He X, Song Y, Ma L, et al. Prevalence and factors influencing sarcopenia among community-dwelling older adults using the Asian Working Group for Sarcopenia Definition. Clin Interv Aging 2022;17:1707-1727.
  38. Japanese Gastric Cancer Association. Japanese Gastric Cancer Treatment Guidelines 2021 (6th edition). Gastric Cancer 2023;26:1-25.
  39. Chang JW, Jung DH, Park JC, et al. Long-term outcomes and prognostic factors of endoscopic submucosal dissection for early gastric cancer in patients aged ≥75 years. Cancers (Basel) 2020;12:3222.
  40. Waki K, Shichijo S, Uedo N, et al. Long-term outcomes after endoscopic resection for late-elderly patients with early gastric cancer. Gastrointest Endosc 2022;95:873-883.
  41. Rom H, Tamir S, Van Vugt JL, et al. Sarcopenia as a predictor of survival in patients with pancreatic adenocarcinoma after pancreatectomy. Ann Surg Oncol 2022;29:1553-1563.
  42. Ishida T, Makino T, Yamasaki M, et al. Quantity and quality of skeletal muscle as an important predictor of clinical outcomes in patients with esophageal cancer undergoing esophagectomy after neoadjuvant chemotherapy. Ann Surg Oncol 2021;28:7185-7195.
  43. Tsukuma H, Mishima T, Oshima A. Prospective study of "early" gastric cancer. Int J Cancer 1983;31:421-426.
  44. Goto S, Arimoto J, Higurashi T, et al. Efficacy and safety of colorectal endoscopic submucosal dissection in patients with sarcopenia. Surg Endosc 2021;35:5489-5496.
  45. Kudo S, Chinda D, Shimoyama T, et al. Influence of esophageal endoscopic submucosal dissection on the changes of energy metabolism during the perioperative period. Cancers (Basel) 2022;14:2015.