Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Characterization of Carbamazepine-Imprinted Acorn Starch/PVA-Based Biomaterials

카바마제핀 각인 도토리 전분/PVA 기반 바이오소재의 특성

  • Kyeong-Jung Kim (Department of Chemical and Biomolecular Engineering, Chonnam National University) ;
  • Ji-Hoon Kang (Department of Chemical and Biomolecular Engineering, Chonnam National University) ;
  • Bo-Gyeong Kim (Department of Chemical and Biomolecular Engineering, Chonnam National University) ;
  • Min‑Jin Hwang (Department of Environmental System Engineering, Chonnam National University) ;
  • Soon-Do Yoon (Department of Chemical and Biomolecular Engineering, Chonnam National University)
  • 김경중 (전남대학교 공학대학 화공생명공학과) ;
  • 강지훈 (전남대학교 공학대학 화공생명공학과) ;
  • 김보경 (전남대학교 공학대학 화공생명공학과) ;
  • 황민진 (전남대학교 공학대학 환경시스템공학과) ;
  • 윤순도 (전남대학교 공학대학 화공생명공학과)
  • Received : 2024.04.01
  • Accepted : 2024.04.16
  • Published : 2024.06.10
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Abstract

In this study, carbamazepine (CBZ) imprinted starch/PVA-based biomaterials were prepared by the casting method and UV irradiation, and their physicochemical properties, CBZ adsorption ability, and release properties were investigated. The surface properties of the prepared biomaterials were characterized using FE-SEM, while the stability of CBZ under UV irradiation and the functional groups of the biomaterials were characterized using FT-IR analysis. The adsorption properties of CBZ on the biomaterials were evaluated by binding isotherm and Scatchard plot. Results indicate that CBZ imprinted biomaterials possess a specific binding site of CBZ. To evaluate the applicability of the transdermal drug delivery system, the release properties of CBZ from prepared biomaterials using various pH buffers and artificial skin at 36.5 ℃ were investigated. Results indicated that the CBZ release at high pH was faster than at low pH. In addition, CBZ was released continuously for 12 h in the artificial skin test. The drug release mechanism of CBZ followed a pseudo-Fickian diffusion mechanism in buffer solution, whereas the release from artificial skin exhibited a non-Fickian diffusion mechanism.

본 연구에서 carbamazepine (CBZ) 각인 도토리 전분(acorn starch, AS)/PVA 기반 바이오소재를 casting method와 UV 조사를 이용하여 제조하고 물리·화학적 특성, CBZ 흡착 및 방출 특성을 조사하였다. 제조한 바이오소재의 표면 특성은 FE-SEM을 통해 확인하였고, UV 조사에 따른 CBZ의 안정성과 바이오소재 작용기는 FT-IR 분석을 이용하였다. CBZ에 대한 바이오소재의 흡착 특성은 binding isotherm 및 Scatchard plot으로 평가하였고 이를 통해 CBZ 각인 바이오소재에 CBZ 결합 부위가 존재하는 것을 확인하였다. 경피 약물 전달 시스템의 응용 가능성을 평가하기 위하여 36.5 ℃에서 다양한 pH의 완충용액과 인공피부를 이용해 제조한 바이오소재의 CBZ 방출 특성을 조사하였다. 이 결과, CBZ는 pH 가 증가할수록 빠른 방출 속도를 보였으며, 인공피부 테스트에서 12 h 동안 지속적으로 방출되었다. 또한, 수학적 모델을 적용시킨 결과, 완충용액에서 CBZ 방출 메커니즘은 pseudo-Fickian diffusion 메커니즘을 따랐고 인공피부에서 non-Fickian diffusion 메커니즘을 따르는 것으로 평가되었다.

Keywords

Acknowledgement

이 논문은 2019년 정부(교육부)의 재원으로 한국연구재단의 지원을 받아 수행된 기초연구사업(Grant No. NRF-2019R1I1A3A01061508)에 의해 수행하였음.

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