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Conceptional design of an adjustable moderator for BNCT based on a neutron source of 2.8 MeV proton bombarding with Li target

  • Yinan Zhu (Shanghai Institute of Applied Physics, Chinese Academy of Sciences) ;
  • Zuokang Lin (Shanghai Institute of Applied Physics, Chinese Academy of Sciences) ;
  • Haiyan Yu (Shanghai Institute of Applied Physics, Chinese Academy of Sciences) ;
  • Xiaohan Yu (Shanghai Institute of Applied Physics, Chinese Academy of Sciences) ;
  • Zhimin Dai (Shanghai Institute of Applied Physics, Chinese Academy of Sciences)
  • Received : 2023.05.12
  • Accepted : 2023.12.17
  • Published : 2024.05.25

Abstract

Beam shaping assembly (BSA) is a vital component in Boron Neutron Capture Therapy (BNCT) for obtaining epithermal neutron beams. Several feasible designs of BSA for accelerator-based BNCT (AB-BNCT) neutron source are carried out based on neutrons by bombarding a natural lithium target with 10 mA, 2.8 MeV proton beams. The calculation results demonstrate that a thickness of 45 cm is appropriate for general moderators referring to the therapeutic parameter of Advanced Depth (AD). A series of optimizations are performed and two results are confirmed: One is that employing the configuration of MgF2 and FLUENTAL combined by 1:1 could improve the therapeutic rate (TR) of tumors at a depth of middle region, and the other one is that the TR of superficial tumors can be increased by adding a 5 cm thick boron-11 secondary moderator at the end of general moderators. As a result, an innovative conception of an adjustable moderator is recommended to BNCT. Compared to the MgF2 moderator with a fixed thickness of 45 cm, the TR value can be improved by a maximum of 47.7 % by using the adjustable moderator. Furthermore, the configuration of adjustable moderator has been designed with regulation method for treating tumors of different depths.

Keywords

Acknowledgement

This work is supported by Shanghai Institute of Applied Physics, Chinese Academy of Sciences, New Education Program (No. Y955071031).

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