Nuclear Engineering and Technology

Korean Nuclear Society (한국원자력학회)
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Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)

  • Fathyah Whba (Department of Physics, Faculty of Applied Science, Taiz University) ;
  • Faizal Mohamed (Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia) ;
  • Mohd Idzat Idris (Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia) ;
  • Rawdah Whba (Department of Chemistry, Faculty of Applied Science, Taiz University) ;
  • Noramaliza Mohd Noor (Department of Radiology, Faculty of Medicine and Health Science, Universiti Putra Malaysia)
  • Received : 2023.04.16
  • Accepted : 2023.12.17
  • Published : 2024.05.25
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Abstract

The attractive properties of gadolinium-based nanoparticles as a positive contrast agent for magnetic resonance imaging (MRI) have piqued the interest of both researchers and clinicians. Nonetheless, due to the biotoxicity of gadolinium (III) ions' free radicals, there is a need to address this issue. Therefore, this research aimed to develop a biocompatible, dispersible, stable, hydrophilic, and less toxic cellulose nanocrystals/gadolinium oxide nanocomposite as contrast agent properties for MRI purposes. This study aimed to synthesize gadolinium oxide nanoparticles coated with cellulose nanocrystals with polyethylene glycol and sodium hydroxide (CNCs-PEG/NaOH)/Gd2O3 using the gamma irradiation method to reduce the particle size. The results showed that using a gamma irradiation dose of 10 kGy, quasi-spherical morphology with a size of approximately 5.5 ± 0.65 nm could be produced. Furthermore, the cytocompatibility of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite synthesized was assessed through MTT assay tests on Hep G2 cells, which demonstrated good cytocompatibility without any cytotoxic effects within a concentration range of (10 ㎍/mL - 150 ㎍/mL) and had sufficient cellular uptake. Moreover, the T1-weighted MRI of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite revealed promising results as a positive contrast agent. It is envisaged that the gamma irradiation method is promising in synthesizing (CNCs-PEG/NaOH)/Gd2O3 nanocomposite with nanoscale for different applications, especially in the radiotherapy field.

Keywords

Acknowledgement

The authors express their gratitude to Universiti Kebangsaan Malaysia (UKM) for their support through grants UKM-GUP-2022-046 and UKM-GUP-2020-035. They would also like to extend their appreciation to the government of Yemen, represented by the Ministry of Higher Education and Scientific Research, for their funding of the scholar project.

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