Development and Reproduction (한국발생생물학회지:발생과생식)

The Korean Society of Developmental Biology (한국발생생물학회)
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Physiology of Cellular Prion Proteins in Reproduction

  • Zeljko M. Svedruzic (Department of Biotechnology, University of Rijeka) ;
  • Chongsuk Ryou (Department of Pharmacy, College of Pharmacy, Hanyang University ERICA) ;
  • Donchan Choi (Department Life Science, College of Health Science and Welfare, Yong-In University) ;
  • Sung-Ho Lee (Department of Biotechnology, Sangmyung University) ;
  • Yong-Pil Cheon (Division of Developmental Biology and Physiology, Department of Biotechnology, Institute for Basic Sciences, Sungshin University)
  • Received : 2024.03.13
  • Accepted : 2024.03.30
  • Published : 2024.06.30
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Abstract

Cellular prion protein (PrPC) encoded at Prnp gene is well-known to form a misfolded isoform, termed scrapie PrP (PrPSC) that cause transmissible degenerative diseases in central nervous system. The physiological role of PrPC has been proposed by many studies, showing that PrPC interacts with various intracellular, membrane, and extracellular molecules including mitochondrial inner membrane as a scaffold. PrPC is expressed in most cell types including reproductive organs. Numerous studies using PrPC knockout rodent models found no obvious phenotypic changes, in particular the clear phenotypes in development and reproduction have not demonstrated in these knockout models. However, various roles of PrPC have been evaluated at the cellular levels. In this review, we summarized the known roles of PrPC in various cell types and tissues with a special emphasis on those involved in reproduction.

Keywords

Acknowledgement

This work was supported by National Research Foundation of Korea (NRF)-2021K1A4A7A02098794 and 2023R1A2C3007223121.

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