Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
권호 표지
DOI QR코드

DOI QR Code

Protective effect of Phyllostachys edulis (Carrière) J. Houz against chronic ethanol-induced cognitive impairment in vivo

  • Jiyeon Kim (Department of Food Science and Nutrition, Pusan National University) ;
  • Ji Myung Choi (Department of Food and Nutrition, Kyungsung University) ;
  • Ji-Hyun Kim (Department of Food Science and Nutrition, Pusan National University) ;
  • Qi Qi Pang (Department of Food Science and Nutrition, Pusan National University) ;
  • Jung Min Oh (Department of Food Science and Nutrition, Pusan National University) ;
  • Ji Hyun Kim (Department of Food Science and Nutrition, Gyeongsang National University) ;
  • Hyun Young Kim (Department of Food Science and Nutrition, Gyeongsang National University) ;
  • Eun Ju Cho (Department of Food Science and Nutrition, Pusan National University)
  • Received : 2024.02.21
  • Accepted : 2024.05.09
  • Published : 2024.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

BACKGROUND/OBJECTIVES: Chronic alcohol consumption causes oxidative stress in the body, which may accumulate excessively and cause a decline in memory; problem-solving, learning, and exercise abilities; and permanent damage to brain structure and function. Consequently, chronic alcohol consumption can cause alcohol-related diseases. MATERIALS/METHODS: In this study, the protective effects of Phyllostachys edulis (Carrière) J. Houz (PE) against alcohol-induced neuroinflammation and cognitive impairment were evaluated using a mouse model. Alcohol (16%, 5 g/kg/day for 6 weeks) and PE (100, 250, and 500 mg/kg/day for 21 days) were administered intragastrically to mice. RESULTS: PE showed a protective effect against memory deficits and cognitive dysfunction caused by alcohol consumption, confirmed through behavioral tests such as the T-maze, object recognition, and Morris water maze tests. Additionally, PE attenuated oxidative stress by reducing lipid oxidation, nitric oxide, and reactive oxygen species levels in the mice's brains, livers, and kidneys. Improvement of neurotrophic factors and downregulation of apoptosis-related proteins were confirmed in the brains of mice fed low and medium concentrations of PE. Additionally, expression of antioxidant enzyme-related proteins GPx-1 and SOD-1 was enhanced in the liver of PE-treated mice, related to their inhibitory effect on oxidative stress. CONCLUSION: This suggests that PE has both neuroregenerative and antioxidant effects. Collectively, these behavioral and histological results confirmed that PE could improve alcohol-induced cognitive deficits through brain neurotrophic and apoptosis protection and modulation of oxidative stress.

Keywords

References

  1. Grant BF, Dawson DA, Stinson FS, Chou SP, Dufour MC, Pickering RP. The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002. Drug Alcohol Depend 2004;74:223-34.
  2. Zahr NM, Kaufman KL, Harper CG. Clinical and pathological features of alcohol-related brain damage. Nat Rev Neurol 2011;7:284-94.
  3. Butterworth RF. Hepatic encephalopathy--a serious complication of alcoholic liver disease. Alcohol Res Health 2003;27:143-5.
  4. Cheon YH, Joe KH, Kim DJ. Alcohol-related dementia. J Korean Geriatr Psychiatry 2012;16:89-96.
  5. Korea Forest Research Institute. Encyclopedia of Bamboos in Korea; New Research Report 7. Seoul: Ukgo Publishing; 2005; p. 203.
  6. Cho WD. Studies on the functional components extracted from bamboo. Coop Manag Inst 2000;23:95-108.
  7. Cho E, Kim S, Na I, Kim DC, In MJ, Chae HJ. Antioxidant and anticoagulant activities of water and ethanol extracts of Phyllostachys pubescence leaf produced in Geoje. J Appl Biol Chem 2010;53:170-3.
  8. Shibata M, Sato F, Takeshita K, Otani K. Pharmacological studies on bamboo grass Sasa-albomarginata 5. Combined effects of the extract F-D with vitamin C. Shoyakugaku Zasshi 1980;34:274-9.
  9. Heo, J. DongUiBoGam-DongUiBoGam Korean Translate Committee. Seoul: Bubinmunhwasa; 1990. p. 192-1392.
  10. Tundis R, Augimeri G, Vivacqua A, Romeo R, Sicari V, Bonofiglio D, Loizzo MR. Anti-inflammatory and antioxidant effects of leaves and sheath from bamboo (Phyllostacys edulis J. Houz). Antioxidants 2023;12:1239.
  11. Rajebhosale VA, Burte RG, Toro VA. Nutritive value of bamboo (Dendrocalamus calostachyus) leaves for crossbred calves. Indian J Anim Nutr 1998;15:58-60.
  12. Tsunoda S, Yamamoto K, Sakamoto S, Inoue H, Nagasawa H. Effects of Sasa Health, extract of bamboo grass leaves, on spontaneous mammary tumourigenesis in SHN mice. Anticancer Res 1998;18:153-8
  13. Michiko F. Difference between bamboo shoots and vegetables in thermal disintegration of tissues and polysaccharides fractionated by successive extraction. J Food Sci 1990;55:739-45.
  14. Montgomery KC. A test of two explanations of spontaneous alternation. J Comp Physiol Psychol 1952;45:287-93.
  15. Antunes M, Biala G. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process 2012;13:93-110.
  16. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984;11:47-60.
  17. Muhammad T, Ali T, Ikram M, Khan A, Alam SI, Kim MO. Melatonin rescue oxidative stress-mediated neuroinflammation/neurodegeneration and memory impairment in scopolamine-induced amnesia mice model. J Neuroimmune Pharmacol 2019;14:278-94.
  18. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.
  19. Schmidt HH, Pollock JS, Nakane M, Forstermann U, Murad F. Ca2+/calmodulin-regulated nitric oxide synthases. Cell Calcium 1992;13:427-34.
  20. Gerridzen IJ, Hertogh CM, Depla MF, Veenhuizen RB, Verschuur EM, Joling KJ. Neuropsychiatric symptoms in people with Korsakoff syndrome and other alcohol-related cognitive disorders living in specialized long-term care facilities: prevalence, severity, and associated caregiver distress. J Am Med Dir Assoc 2018;19:240-7.
  21. Huang WJ, Zhang X, Chen WW. Association between alcohol and Alzheimer's disease. Exp Ther Med 2016;12:1247-50.
  22. Signorini-Allibe N, Gonthier B, Lamarche F, Eysseric H, Barret L. Chronic consumption of ethanol leads to substantial cell damage in cultured rat astrocytes in conditions promoting acetaldehyde accumulation. Alcohol Alcohol 2005;40:163-71.
  23. Koop DR. Alcohol metabolism's damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1. Alcohol Res Health 2006;29:274-80.
  24. Climent E, Pascual M, Renau-Piqueras J, Guerri C. Ethanol exposure enhances cell death in the developing cerebral cortex: role of brain-derived neurotrophic factor and its signaling pathways. J Neurosci Res 2002;68:213-25.
  25. Kweon MH, Hwang HJ, Sung HC. Identification and antioxidant activity of novel chlorogenic acid derivatives from bamboo (Phyllostachys edulis). J Agric Food Chem 2001;49:4646-55.
  26. Kim EY, Lee MJ, Song YO, Moon GS. Effect of maengjong-juk (Phyllostachys pubescens) extract coated rice diet on antioxidative system of C57BL/6 mice fed atherogenic diet. Korean J Community Nutr 2004;9:536-44.
  27. Mamiya T, Kise M, Morikawa K. Ferulic acid attenuated cognitive deficits and increase in carbonyl proteins induced by buthionine-sulfoximine in mice. Neurosci Lett 2008;430:115-8.
  28. Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006;1:848-58.
  29. Bevins RA, Besheer J. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'. Nat Protoc 2006;1:1306-11.
  30. Alderson RF, Alterman AL, Barde YA, Lindsay RM. Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron 1990;5:297-306.
  31. Peregud DI, Baronets VY, Terebilina NN, Gulyaeva NV. Role of BDNF in neuroplasticity associated with alcohol dependence. Biochemistry (Mosc) 2023;88:404-16.
  32. MacLennan AJ, Lee N, Walker DW. Chronic ethanol administration decreases brain-derived neurotrophic factor gene expression in the rat hippocampus. Neurosci Lett 1995;197:105-8.
  33. Abrahao KP, Salinas AG, Lovinger DM. Alcohol and the brain: neuronal molecular targets, synapses, and circuits. Neuron 2017;96:1223-38.
  34. Ceballos N, Sharma S. Risk and resilience: the role of brain-derived neurotrophic factor in alcohol use disorder. AIMS Neurosci 2016;3:398-432.