DOI QR코드

DOI QR Code

Enteral Nutrition in Critically Ill Patient With Septic Shock Requiring Vasopressor: Case Report

  • Hee Young Kim (Department of Nutrition, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Min Young Noh (Department of Nutrition, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Jisun Lee (Department of Nutrition, Seoul St. Mary's Hospital, The Catholic University of Korea)
  • Received : 2023.12.28
  • Accepted : 2024.01.16
  • Published : 2024.01.31

Abstract

Nutritional support in critically ill patients is an essential aspect of treatment. In particular, the benefits of enteral nutrition (EN) are well recognized, and various guidelines recommend early EN within 48 hours in critically ill patients. However, there is still controversy regarding EN in critically ill patients with septic shock requiring vasopressors. Therefore, this case report aims to provide basic data for the safe and effective nutritional support in septic shock patients who require vasopressors. A 62-year-old male patient was admitted to the intensive care unit with a deep neck infection and mediastinitis that progressed to a septic condition. Mechanical ventilation was initiated after intubation due to progression of respiratory acidosis and deterioration of mental status, and severe hypotension required the initiation of norepinephrine. Due to hemodynamic instability, the patient was kept nil per os. Subsequently, trophic feeding was initiated at the time of norepinephrine dose tapering and was gradually increased to achieve 75% of the energy requirement through EN by the 7th day of enteral feeding initiation. Although there were signs of feeding intolerance during the increasing phase of EN, adjusting the rate of EN resolved the issue. This case report demonstrates the gradual progression and adherence to EN in septic shock patient requiring vasopressors, and the progression observed was relatively consistent with existing studies and guidelines. In the future, further case reports and continuous research will be deemed necessary for safe and effective nutritional support in critically ill patients with septic shock requiring vasopressors.

Keywords

References

  1. Mueller CM, Lord LM, Marian M, McClave SA, Miller SJ. Overview of enteral nutrition. In: Doley J, Phillips W, editors. The ASPEN adult nutrition support core curriculum. 3rd ed. Silver Spring (MD): American Society for Parenteral and Enteral Nutrition; 2017. p. 213-23.
  2. McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, Gervasio JM, Sacks GS, Roberts PR, Compher C; Society of Critical Care MedicineAmerican Society for Parenteral and Enteral Nutrition. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr 2016;40:159-211.
  3. Singer P, Blaser AR, Berger MM, Calder PC, Casaer M, Hiesmayr M, Mayer K, Montejo-Gonzalez JC, Pichard C, Preiser JC, Szczeklik W, van Zanten AR, Bischoff SC. ESPEN practical and partially revised guideline: clinical nutrition in the intensive care unit. Clin Nutr 2023;42:1671-89.
  4. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315:801-10.
  5. Allen JM. Vasoactive substances and their effects on nutrition in the critically ill patient. Nutr Clin Pract 2012;27:335-9.
  6. Piton G, Le Gouge A, Boisrame-Helms J, Anguel N, Argaud L, Asfar P, Botoc V, Bretagnol A, Brisard L, Bui HN, Canet E, Chatelier D, Chauvelot L, Darmon M, Das V, Devaquet J, Djibre M, Ganster F, Garrouste- Orgeas M, Gaudry S, Gontier O, Groyer S, Guidet B, Herbrecht JE, Hourmant Y, Lacherade JC, Letocart P, Martino F, Maxime V, Mercier E, Mira JP, Nseir S, Quenot JP, Richecoeur J, Rigaud JP, Roux D, Schnell D, Schwebel C, Silva D, Sirodot M, Souweine B, Thieulot-Rolin N, Tinturier F, Tirot P, Thevenin D, Thiery G, Lascarrou JB, Reignier J; Clinical Research in Intensive Care and Sepsis (CRICS) group. Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial. Intensive Care Med 2022;48:458-66.
  7. Reintam Blaser A, Starkopf J, Alhazzani W, Berger MM, Casaer MP, Deane AM, Fruhwald S, Hiesmayr M, Ichai C, Jakob SM, Loudet CI, Malbrain ML, Montejo Gonzalez JC, Paugam-Burtz C, Poeze M, Preiser JC, Singer P, van Zanten AR, De Waele J, Wendon J, Wernerman J, Whitehouse T, Wilmer A, Oudemans-van Straaten HM; ESICM Working Group on Gastrointestinal Function. Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Med 2017;43:380-98.
  8. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Moller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 2021;47:1181-247.
  9. Ohbe H, Jo T, Matsui H, Fushimi K, Yasunaga H. Differences in effect of early enteral nutrition on mortality among ventilated adults with shock requiring low-, medium-, and high-dose noradrenaline: a propensity-matched analysis. Clin Nutr 2020;39:460-7.
  10. Merchan C, Altshuler D, Aberle C, Papadopoulos J, Schwartz D. Tolerability of enteral nutrition in mechanically ventilated patients with septic shock who require vasopressors. J Intensive Care Med 2017;32:540-6.
  11. Mancl EE, Muzevich KM. Tolerability and safety of enteral nutrition in critically ill patients receiving intravenous vasopressor therapy. JPEN J Parenter Enteral Nutr 2013;37:641-51.
  12. Flordelis Lasierra JL, Montejo Gonzalez JC, Lopez Delgado JC, Zarate Chug P, Martinez Lozano-Aranaga F, Lorencio Cardenas C, Bordeje Laguna ML, Maichle S, Terceros Almanza LJ, Trasmonte Martinez MV, Mateu Campos L, Servia Goixart L, Vaquerizo Alonso C, Vila Garcia B; the NUTRIVAD Study Group. Enteral nutrition in critically ill patients under vasoactive drug therapy: the NUTRIVAD study. JPEN J Parenter Enteral Nutr 2022;46:1420-30.