Acknowledgement
This research was funded by National Science Centre, Poland by grants OPUS (no. 2016/23/B/NZ7/01143), MINIATURA (no. 2019/03/X/NZ7/00644) and by Maj Institute of Pharmacology, Polish Academy of Sciences with Departmental Statutory funds. We would like to thank Galen Ortopedia Sp. z o.o.'s medical doctors and Department of Science, Innovation and Development for providing synovial membranes. Neuroepithelial stem cells were a kind gift of Anna Falk (Karolinska Institutet, Solna, Sweden).
References
- de Sousa EB, Casado PL, Moura Neto V, Duarte ME, Aguiar DP. Synovial fluid and synovial membrane mesenchymal stem cells: latest discoveries and therapeutic perspectives. Stem Cell Res Ther 2014;5:112
- Grassel SG. The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology. Arthritis Res Ther 2014;16:485
- Vasconcelos DP, Jabangwe C, Lamghari M, Alves CJ. The neuroimmune interplay in joint pain: the role of macrophages. Front Immunol 2022;13:812962
- Cope PJ, Ourradi K, Li Y, Sharif M. Models of osteoarthritis: the good, the bad and the promising. Osteoarthritis Cartilage 2019;27:230-239
- Roque PJ, Costa LG. Co-culture of neurons and microglia. Curr Protoc Toxicol 2017;74:11.24.1-11.24.17
- Zhao H, Sun P, Fan T, Yang X, Zheng T, Sun C. The effect of glutamate-induced excitotoxicity on DNA methylation in astrocytes in a new in vitro neuron-astrocyte-endothelium co-culture system. Biochem Biophys Res Commun 2019;508:1209-1214
- Marcotti A, Miralles A, Dominguez E, et al. Joint nociceptor nerve activity and pain in an animal model of acute gout and its modulation by intra-articular hyaluronan. Pain 2018;159:739-748
- Calvo-Garrido J, Winn D, Maffezzini C, et al. Protocol for the derivation, culturing, and differentiation of human iPScell-derived neuroepithelial stem cells to study neural differentiation in vitro. STAR Protoc 2021;2:100528
- Alshawaf AJ, Viventi S, Qiu W, et al. Phenotypic and functional characterization of peripheral sensory neurons derived from human embryonic stem cells. Sci Rep 2018;8:603
- Lowin T, Zhu W, Dettmer-Wilde K, Straub RH. Cortisolmediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system. Arthritis Rheum 2012;64:3867-3876
- Chwastek J, Kedziora M, Borczyk M, Korostynski M, Starowicz K. Inflammation-driven secretion potential is upregulated in osteoarthritic fibroblast-like synoviocytes. Int J Mol Sci 2022;23:11817
- Xie Z, Bailey A, Kuleshov MV, et al. Gene set knowledge discovery with Enrichr. Curr Protoc 2021;1:e90
- Bufalo MC, Almeida MES, Jensen JR, et al. Human sensory neuron-like cells and glycated collagen matrix as a model for the screening of analgesic compounds. Cells 2022;11:247
- Hui AY, McCarty WJ, Masuda K, Firestein GS, Sah RL. A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med 2012;4:15-37
- Zhao J, Guo S, Schrodi SJ, He D. Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications. Front Immunol 2021;12:790122
- Hu SQ, Hu JL, Zou FL, et al. P2X7 receptor in inflammation and pain. Brain Res Bull 2022;187:199-209
- Falk A, Koch P, Kesavan J, et al. Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One 2012;7:e29597
- Yuan A, Sasaki T, Kumar A, et al. Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons. J Neurosci 2012;32:8501-8508
- Sleigh JN, Dawes JM, West SJ, et al. Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations. Proc Natl Acad Sci U S A 2017;114:E3324-E3333
- Mehta B, Goodman S, DiCarlo E, et al. Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation. Arthritis Res Ther 2023;25:31
- Han D, Fang Y, Tan X, et al. The emerging role of fibroblast-like synoviocytes-mediated synovitis in osteoarthritis: an update. J Cell Mol Med 2020;24:9518-9532
- Ai M, Lin S, Zhang M, et al. Cirsilineol attenuates LPS-induced inflammation in both in vivo and in vitro models via inhibiting TLR-4/NFkB/IKK signaling pathway. J Biochem Mol Toxicol 2021;35:e22799
- Yan L, Liang M, Yang T, et al. The immunoregulatory role of myeloid-derived suppressor cells in the pathogenesis of rheumatoid arthritis. Front Immunol 2020;11:568362
- Koles L, Leichsenring A, Rubini P, Illes P. P2 receptor signaling in neurons and glial cells of the central nervous system. Adv Pharmacol 2011;61:441-493
- Lin J, Sun AR, Li J, et al. A three-dimensional co-culture model for rheumatoid arthritis pannus tissue. Front Bioeng Biotechnol 2021;9:764212
- Rothbauer M, Holl G, Eilenberger C, et al. Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing. Lab Chip 2020;20:1461-1471