Pediatric Gastroenterology, Hepatology & Nutrition

  • 제27권4호
  • /
  • Pages.246-257
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  • 2024
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  • 2234-8646(pISSN)
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  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
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Benefits and Risks of Preprepared Parenteral Nutrition for Early Amino Acid Administration in Premature Infants with Very Low Birth Weight

  • Pin-Chun Chen (Department of Pharmacy, Taipei City Hospital) ;
  • Hsin-Chung Huang (Department of Pediatrics, National Taiwan University Hospital) ;
  • Mei-Jy Jeng (Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang Ming Chiao Tung University) ;
  • Feng-Shiang Cheng (Department of Education and Research, Taipei City Hospital)
  • 투고 : 2023.06.13
  • 심사 : 2024.05.26
  • 발행 : 2024.07.15
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초록

Purpose: Administering early parenteral amino acids to very low birth weight (VLBW) premature infants (birth body weight [BBW]<1,500 g) is challenging due to factors such as holidays, cost, and access to sterile compounding facilities. Using advance-prepared parenteral nutrition (PN) may address this issue and should be evaluated for its safety and potential benefits. Methods: We extracted data from medical records collected between July 2015 and August 2019. VLBW infants received PN for at least seven days and were split into two groups: the traditional group (n=30), which initially received a glucose solution and then PN on workdays, and the pre-preparation group (n=16), which received advance-prepared PN immediately upon admission to the neonatal intensive care unit. Results: The median BBWs of the traditional and pre-preparation groups were 1,180.0 vs. 1,210.0 g. In the initial two days, the pre-preparation group had a significantly higher amino acid intake (2.23 and 2.24 g/kg/d) than the traditional group (0 and 1.78 g/kg/d). The pre-preparation group exhibited greater head circumference growth ratio relative to birth (7th day: 1.21% vs. -3.57%, p=0.014; 21st day: 7.71% vs. 3.31%, p=0.017). No significant differences in metabolic tolerance were observed. Conclusion: Advanced preparation of PN can be safely implemented in VLBW preterm infants, offering advantages such as early, higher amino acid intake and improved head circumference growth within the first 21 days post-birth. This strategy may serve as a viable alternative in settings where immediate provision of sterile compounding facilities is challenging.

키워드

과제정보

This research was supported by the Heping, Fuyou Branch, Department of Pharmacy, Taipei City Hospital.

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