Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Replication Study of Genome Wide Association Study of Sleep Duration in Korean Association Resources Cohort

  • Seok-Ho Cho (Department of Biomedical Laboratory Science, Korea Nazarene University) ;
  • Seon-Ah Kim (Department of Biomedical Laboratory Science, Korea Nazarene University) ;
  • Hyun-Seok Jin (Department of Biomedical Laboratory Science, College of Life and Health Science, Hoseo University) ;
  • Hong Sung Kim (Department of Biomedical Laboratory Science, Korea Nazarene University)
  • Received : 2024.05.31
  • Accepted : 2024.06.28
  • Published : 2024.06.30
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Abstract

Sleep varies from individual to individual and is essential for maintaining good health, making it important for the health of individuals and societies. Sleep duration is influenced by both genetic and environmental factors, and sleep duration has been reported to be associated with obesity, metabolic syndrome, diabetes, and cardiovascular disease. In this study, we identified SNPs associated with sleep duration from the genome-wide association study (GWAS) catalog and compared them with the Korean Association Resource (KARE) cohort to find SNPs associated with sleep duration in Koreans and to identify the genes involved. The results showed that rs1553132, a SNP in the GRM5 gene, was identified as an SNP associated with sleep duration in both the GWAS catalog and the KARE cohort, and rs1504096 was the first SNP found to be associated with sleep duration in Koreans. It was found that having a minor allele tended to increase sleep duration. These results confirm the reproducibility of the association between sleep duration and the GRM5 gene in Koreans and provide a basis for using the associated SNPs as genetic determinants of sleep duration.

Keywords

Acknowledgement

Epidemiologic data used in this study were from the Korean Genome and Epidemiology Study (KoGES) of the Korea Centers for Disease Control & Prevention, Republic of Korea.

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