Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Retrospective Analysis Study of False-Positive Amphetamine Immunoassay Cases and Negative Cases after Withdrawal while Taking Herbal Medicine-Containing Ephedra Sinica Confirmed in a Korean Medicine Obesity Clinic

한의 비만 클리닉에서 확인된 마황 함유 한약 복용 중 암페타민 면역측정법의 위양성 사례 및 휴약 후 음성 사례의 후향적 분석연구

  • 강병수 (다이트 한의원 서울강남점) ;
  • 신수용 (다이트 한의원 인천부평점) ;
  • 김정상 (다이트 한의원 경기수원점) ;
  • 강민휘 (다이트 한의원 경기일산점) ;
  • 이동훈 (다이트 한의원 서울강남점) ;
  • 전성현 (다이트 한의원 서울강남점) ;
  • 방민우 (다이트 한의원 서울강남점)
  • Received : 2024.03.19
  • Accepted : 2024.06.01
  • Published : 2024.06.30
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Abstract

Herbal medicine (HM)-containing Ephedra Sinica (ES) has been associated with false-positive amphetamine immunoassay (FP IA) results. This study retrospectively evaluated the effects of dose, duration, and withdrawal instructions on FP IA and the safety of HM-containing ES at a clinic in Seoul from 2022 to 2023. The study included 6 patients in the FP IA group and 5 patients in the withdrawal instruction negative (Neg) group. The pre-test ephedrine alkaloids dose in the FP IA group was 95.17±31.90 mg, compared with 88.6±20.43 mg in the Neg group. The FP IA group had taken HM for 226.67±152.87 days before testing, and testing was performed while taking HM. In contrast, the Neg group had taken HM for 147.6±23.49 days and had 5.4±1.50 days of withdrawal period before the test following instructions of Korean medicine doctors. All adverse events (AEs) were moderate in severity, and the number of occurrences was similar: 5 in the FP IA group and 7 in the Neg group. AEs included constipation, insomnia (3 cases each), and palpitations (2 cases). The results of this study show that ES-induced FP IA can be resolved with withdrawal instructions and ES can be safely prescribed and administered by Korean medicine doctors. Further studies are needed to determine how to prevent FP IA after taking ES.

다이트 한의원 서울강남점에서 마황 함유 한약을 복용한 비만 환자 중 면역측정법 위양성 사례와 휴약 지시 후 면역측정법 음성 사례에 대해 후향적으로 관찰하였다. 마황에 의해 면역측정법 위양성 사례가 발생할 수 있고 이에 대한 주의가 필요하며, 면역측정법 위양성 결과가 나타나는 마황의 복용량, 복용 기간, 위양성 결과를 피하기 위한 마황 복용 중 휴약 기간 및 암페타민에 대한 민감도와 특이도가 높은 새로운 검사방법의 개발 등에 대한 추가 연구가 필요하다.

Keywords

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