The Korean Journal of Pain

  • 제37권3호
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  • Pages.211-217
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  • 2024
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
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Beneficial effect of metformin on tolerance to analgesic effects of sodium salicylate in male rats

  • Elham Akbari (Department of Physiology, School of Medicine, Torbat Heydariyeh University of Medical Sciences) ;
  • Dawood Hossaini (Department of Physiology, School of Medicine, Torbat Heydariyeh University of Medical Sciences) ;
  • Farimah Beheshti (Department of Physiology, School of Medicine, Torbat Heydariyeh University of Medical Sciences) ;
  • Mahdi Khorsand Ghaffari (Department of Physiology, School of Medicine, Arak University of Medical Sciences) ;
  • Nastran Roshd Rashidi (Department of Physiology, School of Medicine, Arak University of Medical Sciences) ;
  • Masoumeh Gholami (Department of Physiology, School of Medicine, Arak University of Medical Sciences)
  • 투고 : 2024.02.20
  • 심사 : 2024.04.07
  • 발행 : 2024.07.01
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초록

Background: Tolerance to the analgesic effects of opioids and non-steroidal anti-inflammatory drugs (NSAIDs) is a major concern for relieving pain. Thus, it is highly valuable to find new pharmacological strategies for prolonged therapeutic procedures. Biguanide-type drugs such as metformin (MET) are effective for neuroprotection and can be beneficial for addressing opioid tolerance in the treatment of chronic pain. It has been proposed that analgesic tolerance to NSAIDs is mediated by the endogenous opioid system. According to the cross-tolerance between NSAIDs, especially sodium salicylate (SS), and opiates, especially morphine, the objective of this study was to investigate whether MET administration can reduce tolerance to the anti-nociceptive effects of SS. Methods: Fifty-six male Wistar rats were used in this research (weight 200-250 g). For induction of tolerance, SS (300 mg/kg) was injected intraperitoneally for 7 days. During the examination period, animals received MET at doses of 50, 75, or 100 mg/kg for 7 days to evaluate the development of tolerance to the analgesic effect of SS. The hot plate test was used to evaluate the drugs' anti-nociceptive properties. Results: Salicylate injection significantly increased hot plate latency as compared to the control group, but the total analgesic effect of co-treatment with SS + Met50 was stronger than the SS group. Furthermore, the effect of this combination undergoes less analgesic tolerance over time. Conclusions: It can be concluded that MET can reduce the analgesic tolerance that is induced by repeated intraperitoneal injections of SS in Wister rats.

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참고문헌

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