대한수의학회지 (Korean Journal of Veterinary Research)

  • 제64권2호
  • /
  • Pages.9.1-9.7
  • /
  • 2024
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  • 2466-1384(pISSN)
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  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
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Correlation of red cell distribution width and left atrial enlargement in Maltese dogs with myxomatous mitral valve disease in Republic of Korea

  • Hyun-Soon Choi (College of Veterinary Medicine, Chungnam National University) ;
  • Han-Joon Lee (College of Veterinary Medicine, Chungnam National University) ;
  • Joong-Hyun Song (College of Veterinary Medicine, Chungnam National University) ;
  • Kun-Ho Song (College of Veterinary Medicine, Chungnam National University)
  • 투고 : 2024.01.15
  • 심사 : 2024.05.15
  • 발행 : 2024.06.30
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초록

Myxomatous mitral valve disease (MMVD) is a degenerative disease of the valve leaflets, causing left atrial dilatation and eccentric hypertrophy of the left ventricle by hemodynamic instability. Red cell distribution width (RDW) is a hematologic parameter that indicates the variation of red blood cell volume and size, reflecting anisocytosis. Human studies have found that anisocytosis is associated with poor prognosis in heart disease patients, and recent veterinary studies have also confirmed that the increase in RDW is associated with high mortality in MMVD patients. Medical records of 37 Maltese dogs with MMVD were retrospectively reviewed. When comparing RDW among the MMVD stage groups, there was a significant difference between stage B1, B2 and C. A significant and strong correlation between RDW and the left atrial-to-aortic ratio was identified. RDW was significantly correlated with the reticulocyte count independent of hematocrit, and the reticulocyte count exhibited a significant increase at stage C. This suggests that the congestive heart failure secondary to MMVD could be a contributory factor leading to an elevation in RDW. In conclusion, elevated RDW may associated with left atrial enlargement and progression of MMVD.

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과제정보

This work was supported by research fund of Chungnam National University (2023-0870-01).

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