Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Effects of Cannabis sativa Extract on Skin Physiology and Activity

대마추출물의 피부생리 및 활성에 미치는 영향

  • Mu Jun Kim (College of Biomedical and Health Science, Konkuk University) ;
  • Jung Un Shin (College of Biomedical and Health Science, Konkuk University) ;
  • Hyun Kee Kim (Ucellpharma) ;
  • Dong Wook Shin (College of Biomedical and Health Science, Konkuk University)
  • 김무준 (건국대학교 바이오웰니스융합학과) ;
  • 신정언 (건국대학교 바이오웰니스융합학과) ;
  • 김현기 (유셀파마(주)) ;
  • 신동욱 (건국대학교 바이오웰니스융합학과)
  • Received : 2024.05.31
  • Accepted : 2024.06.21
  • Published : 2024.06.30
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Abstract

With the recent trend towards the legalization and relaxation of regulations surrounding medical cannabis, the diverse benefits of cannabis extracts are being scientifically validated, positioning them as promising next-generation ingredients across various fields. Compounds extracted from cannabis, such as cannabinoid (CB), cannabidiol (CBD), phytocannabinoid (pCB), and hemp seed hexane extracts (HSHE), have been shown to reduce skin inflammation, improve moisture retention exhibit strong antioxidant effects, and improve various skin conditions. In this paper, we review the effects of hemp extracts on the skin and explore their potential role as cosmetic ingredients.

최근 의료용 대마의 합법화 추세와 규제가 완화되고 있는 상황 속에서 대마의 다양한 효능이 과학적으로 입증되고 있기 때문에 여러 분야에서 대마추출물이 차세대 유망 성분으로 떠오르고 있다. 대마에서 추출한 성분인 cannabinoid (CB), cannabidiol (CBD), phytocannabinoid (pCB), hemp seed hexane extracts (HSHE)은 피부 염증을 감소시키며 피부 보습, 강력한 항산화 효과가 있고 여러 피부질환 개선에 효능을 가지고 있다. 본 논문에서는 대마추출물들의 피부에서의 효능을 종합하여 소재로서의 잠재적 역할에 대해 살펴보고자 한다.

Keywords

References

  1. C. D. Ciccone, Medical marijuana: Just the beginning of a long, strange trip?, Phys. Ther., 97(2), 239 (2017). 
  2. T. Oberbarnscheidt and N. S. Miller, The impact of cannabidiol on psychiatric and medical conditions, J. Clin. Med. Res., 12(7), 393 (2020). 
  3. G. Baranovi, Understanding the conformational, electronic and vibrational properties of tetrahydrocannabinol (THC) and cannabidiol (CBD). Pharmacophoric similarities and differences, Journal of Molecular Structure, 1244, 130945 (2021). 
  4. S. Karimi-Haghighi, Y. Razavi, D. Iezzi, A. F. Scheyer, O. Manzoni, and A. Haghparast, Cannabidiol and substance use disorder: Dream or reality, Neuropharmacology, 207, 108948 (2022). 
  5. T. Chang, J. Tsen, H. Yen, T. Yang, and H. Huang, Extract from Periostracum cicadae inhibits oxidative stress and inflammation induced by ultraviolet B irradiation on HaCaT keratinocytes, Evid. Based. Complement. Alternat. Med., 2017, 8325049 (2017). 
  6. L. Dong, H. Lee, Z. Liu, and D. S. Lee, Anti-skin inflammatory and anti-oxidative effects of the neoflavonoid latifolin isolated from Dalbergia odorifera in HaCaT and BJ-5ta cells, Int. J. Mol, Sci., 24(8), 7371 (2023). 
  7. L. Xi, C. Wang, P. Chen, Q. Yang, R. Hu, H. Zhang, Q. Weng, and M. Xu, Expressions of IL-6, TNF-alpha and NF-kappaB in the skin of Chinese brown frog (Rana dybowskii), Eur. J. Histochem., 61(4), 2834 (2017). 
  8. E. Sangiovanni, M. Fumagalli, B. Pacchetti, S. Piazza, A. Magnavacca, S. Khalilpour, G. Melzi, G. Martinelli, and M. Dell'Agli, Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury, Phytother., Res. 33, 2083 (2019). 
  9. Y. Wang, X. Wang, Y. Yang, Q. Quan, T. Huo, S . Yang, R. Ju, and Q. An, Comparison of the in vitro anti-inflammatory effect of cannabidiol to dexamethasone, Clin. Cosmet. Investig. Dermatol., 15, 1959 (2022). 
  10. D. Tortolani, C. D. Meo, S. Standoli, F. Ciaramellano, S. Kadhim, E. Hsu, C. Rapino, and M. Maccarrone, Rare phytocannabinoids exert anti-inflammatory effects on human keratinocytes via the endocannabinoid system and MAPK signaling pathway, Int. J. Mol. Sci., 24(3), 2721 (2023). 
  11. S. Jin and M. Y. Lee, The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes, PLoS One., 13(8), e0202933. (2018). 
  12. A. Olah, B. I. Toth, I. Borbiro, K. Sugawara, A. G. Szollosi, G. Czifra, B. Pal, L. Ambrus, J. Kloepper, E. Camera, M. Ludovici, M. Picardo, T. Voets, C. C. Zouboulis, R. Paus, and T. Biro, Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes, J. Clin. Invest, 124(9), 3713 (2014). 
  13. A. Ali and N. Akhtar, The safety and efficacy of 3% cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content, Pak. J. Pharm. Sci., 28(4), 1389 (2015). 
  14. M. Dvorak, A. Watkinson, F. McGlone, and R. Rukwied, Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin, Inflamm. Res., 52(6), 238 (2003). 
  15. J. M. Spradley, A. Davoodi, L. B. Gee, M. I. Carstens, and E. Carstens, Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin, Neuropharmacology, 63(4), 743 (2012). 
  16. C. N. Lungu and I. Mangalagiu, Editorial for special issue-''Research progress and applications of natural products", Molecules 28(14), 5449 (2023). 
  17. C. Liu, H. Li, F. Xu, X. Jiang, H. Ma, and N. P. Seeram, Cannabidiol protects human skin keratinocytes from hydrogen-peroxide-induced oxidative stress via modulation of the caspase-1-IL-1β axis, J. Nat. Prod., 84(5), 1563 (2021). 
  18. V. J. Hearing and K. Tsukamoto, Enzymatic control of pigmentation in mammals, FASEB J., 5(14), 2902(1991). 
  19. K. Nishio, K. Toh, A. Perron, M. Goto, M. Abo, Y. Shimakawa, and M. Uesugi, Magnetic control of cells by chemical fabrication of melanin, J. Am. Chem. Soc, 144(37), 16720 (2022). 
  20. S . Ullah, C. Park, M. Ikram, D. Kang, S . Lee, J. Yang, Y. Park, S . Yoon, P. Chun, and H. R. Moon, Tyrosinase inhibition and anti-melanin generation effect of cinnamamide analogues, Bioorg. Chem, 87, 43 (2019). 
  21. H. Ando, H. Kondoh, M. Ichihashi, and V. J. Hearing, Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase, J. Invest. Dermatol., 127(4), 751 (2007). 
  22. J. K. Kim, H. Y. Heo, S . J. Park, H. Kim, J. J. Oh, E. H. S ohn, S . H. Jung, and K. Lee, Characterization of phenethyl cinnamamide compounds from hemp seed and determination of their melanogenesis inhibitory activity, ACS Omega., 6(47), 31945 (2021). 
  23. Q. Wu, M. Guo, L. Zou, Q. Wang, and Y. Xia, 8,9-Dihydrocannabidiol, an alternative of cannabidiol, its preparation, antibacterial and antioxidant ability, Molecules, 28(1), 445 (2023). 
  24. S. Verdier-Sevrain and F. Bonte, Skin hydration: A review on its molecular mechanisms, J. Cosmet. Dermatol., 6(2), 75 (2007). 
  25. S . Y. Rawal, M. K. Dabbous, and D. A. Tipton, Effect of cannabidiol on human gingival fibroblast extracellular matrix metabolism: MMP production and activity, and production of fibronectin and transforming growth factor β, J. Periodontal. Res., 47(3), 320 (2012). 
  26. M. Zagorska-Dziok, T. Bujak, A. Ziemlewska, and Z. Niziol-Lukaszewska, Positive effect of Cannabis sativa L. herb extracts on skin cells and assessment of cannabinoid-based hydrogels properties, Molecules, 26(4), 802 (2021). 
  27. F. Pollastro, A. Minassi, and L. G. Fresu, Cannabis phenolics and their bioactivities, Curr. Med. Chem, 25(10), 1160 (2018). 
  28. S. A. Seo, H. J. Park, M. G. Han, R. Lee, J. S. Kim, J. H. Park, W. Y. Lee, and H. Song, Fermented colostrum whey upregulates aquaporin-3 expression in, and proliferation of, keratinocytes via p38/C-Jun N-terminal kinase activation, Food Sci. Anim. Resour, 41(5), 749 (2021). 
  29. N. Ikarashi, M. Shiseki, R. Yoshida, K. Tabata, R. Kimura, T. Watanabe, R. Kon, H. Sakai, and J. Kamei, Cannabidiol application increases cutaneous aquaporin-3 and exerts a skin moisturizing effect, Pharmaceuticals (Basel), 14(9), 879 (2021). 
  30. S. Khalilpour, E. Sangiovanni, S. Piazza, M. Fumagalli, G. Beretta, and M. Dell'Agli, In vitro evidences of the traditional use of Rhus coriaria L. fruits against skin inflammatory conditions, J. Ethnopharmacol, 238(28), 111829 (2019). 
  31. T. Muthumalage and I. Rahman, Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts, Toxicol. Appl. Pharmacol, 382, 114713 (2019). 
  32. K. Kongkadee, W. Wisuitiprot, K. Ingkaninan, and N. Waranuch, Anti-inflammation and gingival wound healing activities of Cannabis sativa L. subsp. sativa (hemp) extract and cannabidiol: An in vitro study, Arch. Oral Biol, 140, 105464 (2022). 
  33. A. Telek, T. Biro, E. Bodo, B. I. Toth, I. Borbiro, G. Kunos, and R. Paus, Inhibition of human hair follicle growth by endo- and exocannabinoids, FASEB J., 21, 3534 (2007). 
  34. A. Vallee, Y. Lecarpentier, R. Guillevin, and J. Vallee, Effects of cannabidiol interactions with Wnt/Beta-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease, Acta Biochim. Biophys. Sin. (Shanghai), 49(10), 853 (2017). 
  35. G. L. Smith and J. Satino, Hair regrowth with cannabidiol (CBD)-rich hemp extract - a case series, Cannabis, 4(1), 53 (2021). 
  36. I. L. S zabo, E. Lisztes, G. Beke, K. F. Toth, R. Paus, A. Olah, and T. Biro, The phytocannabinoid (-)-cannabidiol operates as a complex, differential modulator of human hair growth: anti-inflammatory submicromolar versus hair growth inhibitory micromolar effects, J. Invest. Dermatol, 140(2), 484 (2020). 
  37. S . E. Turner, C. M. Williams, L. Iversen, and B. J. Whalley, Molecular pharmacology of phytocannabinoids, Prog. Chem. Org. Nat. Prod, 103, 61 (2017). 
  38. C. D. Rio, E. Millan, V. Garcia, G. Appendino, J. DeMesa, and E. Munoz, The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders, Biochem. Pharmacol, 157, 122 (2018). 
  39. Z. Wang, P. Zheng, X. Chen, Y. Xie, K. Weston-Green, N. Solowij, Y. L. Chew, and X. Huang, Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity, Geroscience, 44(3), 1505 (2022). 
  40. X. Zhang, L. Qi, J. Wu, and Z. Qin, DRAM1 regulates autophagy flux through lysosomes, PLoS One, 8(5), e63245 (2013). 
  41. M. Gerasymchuk, G. I. Robinson, A. Groves, L. Haselhorst, S. Nandakumar, C. Stahl, O. Kovalchuk, and I. Kovalchuk, Phytocannabinoids stimulate rejuvenation and prevent cellular senescence in human dermal fibroblasts, Cells, 11(23), 3939 (2022).