The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Treating Idiopathic Parkinson's Disease with Bonoesikpungjigyeong-tang: A Case Study on "Delayed On" and "Wearing Off" Phenomena after Long-term Levodopa Intake

레보도파 약효 지연 현상 및 약효 감소 현상으로 인한 자세불안정 및 전신탈력감을 호소하는 특발성 파킨슨병 환자에 대한 보뇌식풍지경탕 치험 1례

  • Siyun Sung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Dabin Lee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Seongeun Huh (Dept. of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Sunghee Hong (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Ye-chae Hwang (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Gyeongmuk Kim (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Han-Gyul Lee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Sang-Kwan Moon (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Woo-Sang Jung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Seungwon Kwon (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 성시윤 (경희대학교 대학원 임상한의학과) ;
  • 이다빈 (경희대학교 대학원 임상한의학과) ;
  • 허성은 (경희대학교 한의과대학 순환신경내과학교실) ;
  • 홍성희 (경희대학교 대학원 임상한의학과) ;
  • 황예채 (경희대학교 대학원 임상한의학과) ;
  • 김경묵 (경희대학교 대학원 임상한의학과) ;
  • 이한결 (경희대학교 대학원 임상한의학과) ;
  • 문상관 (경희대학교 대학원 임상한의학과) ;
  • 정우상 (경희대학교 대학원 임상한의학과) ;
  • 권승원 (경희대학교 대학원 임상한의학과)
  • Received : 2024.04.24
  • Accepted : 2024.05.27
  • Published : 2024.05.30
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Abstract

A 69-year-old female diagnosed with idiopathic Parkinson's disease and treated with anti-Parkinsonian medications, including levodopa, for 7 years presented with complaints of wearing-off phenomenon and delayed onset of medication efficacy, resulting in postural instability and feeling of severe exhaustion. The patient underwent a 50-day course of treatment with Bonoesikpungjigyeong-tang formula. The effects of the treatment were evaluated by recording the average time to onset of medication efficacy, the average time to medication wearing-off, and discomfort due to wearing-off phenomenon. Postural instability was assessed using the Numeric Rating Scale (NRS). The patient's overall quality of life was assessed using the EQ-5D-3L. After 50 days of treatment, the average time to onset of medication efficacy decreased, and the average time to medication wearing-off increased. Discomfort due to wearing-off phenomenon and postural instability decreased. This case suggests that Bonoesikpungjigyeong-tang might be an alternative for improving discomfort caused by long-term levodopa intake.

Keywords

References

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