Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications

  • Ying-Chieh Lai (Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou) ;
  • Ching-Yi Hsieh (Department of Medical Imaging and Radiological Sciences, Chang Gung University) ;
  • Yu-Hsiang Juan (Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou) ;
  • Kuan-Ying Lu (Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou) ;
  • Hsien-Ju Lee (Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou) ;
  • Shu-Hang Ng (Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou) ;
  • Yung-Liang Wan (Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou) ;
  • Gigin Lin (Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou)
  • Received : 2024.01.18
  • Accepted : 2024.02.27
  • Published : 2024.05.01
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Abstract

Hyperpolarized (HP) carbon-13 (13C) MRI represents an innovative approach for noninvasive, real-time assessment of dynamic metabolic flux, with potential integration into routine clinical MRI. The use of [1-13C]pyruvate as a probe and its conversion to [1-13C]lactate constitute an extensively explored metabolic pathway. This review comprehensively outlines the establishment of HP 13C-MRI, covering multidisciplinary team collaboration, hardware prerequisites, probe preparation, hyperpolarization techniques, imaging acquisition, and data analysis. This article discusses the clinical applications of HP 13C-MRI across various anatomical domains, including the brain, heart, skeletal muscle, breast, liver, kidney, pancreas, and prostate. Each section highlights the specific applications and findings pertinent to these regions, emphasizing the potential versatility of HP 13C-MRI in diverse clinical contexts. This review serves as a comprehensive update, bridging technical aspects with clinical applications and offering insights into the ongoing advancements in HP 13C-MRI.

Keywords

Acknowledgement

The authors acknowledge the helps from Chun-Yu Su, Yu-Ying Yu, Rainie Liu, Hsin-Ju Chiang, Dr. Lan-Yan Yang, Dr. Yu-Chun Lin, Dr. Kung-Chu Ho, Dr. Rolf F Schulte, Dr. Chien-Yuan Eddy Lin, and GE Healthcare kindly provides investigational sequences in multi-nuclear spectroscopy (MNS) research package.

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