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Cortical Iron Deposition Is Multicausal, and Therefore Cannot Serve as a Biomarker for Early Cognitive Impairment

  • Josef Finsterer (Neurology & Neurophysiology Center) ;
  • Fulvio A Scorza (Disciplina de Neurociencia, Universiade Federal de Sao Paulo/Escola Paulista de Medicinal (UNIFESP/EPM))
  • Received : 2023.10.28
  • Accepted : 2023.11.13
  • Published : 2024.02.01

Abstract

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References

  1. Kim HW, Lee S, Yang JH, Moon Y, Lee J, Moon WJ. Cortical iron accumulation as an imaging marker for neurodegeneration in clinical cognitive impairment spectrum: a quantitative susceptibility mapping study. Korean J Radiol 2023;24:1131-1141 https://doi.org/10.3348/kjr.2023.0490
  2. Galea I, Durnford A, Glazier J, Mitchell S, Kohli S, Foulkes L, et al. Iron deposition in the brain after aneurysmal subarachnoid hemorrhage. Stroke 2022;53:1633-1642 https://doi.org/10.1161/STROKEAHA.121.036645
  3. Seiler A, Schongrundner S, Stock B, Noth U, Hattingen E, Steinmetz H, et al. Cortical aging - new insights with multiparametric quantitative MRI. Aging (Albany NY) 2020;12:16195-16210 https://doi.org/10.18632/aging.103629