대한영상의학회지 (Journal of the Korean Society of Radiology)

  • 제85권2호
  • /
  • Pages.437-444
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  • 2024
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  • 1738-2637(pISSN)
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  • 2288-2928(eISSN)
대한영상의학회 (The Korean Society of Radiology)
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이식신장에 생긴 유두모양 신세포암종과 고유신장에 생긴 Xp11.2전위/전사인자E3-재배열 신세포암종: 증례 보고

Papillary Renal Cell Carcinoma in Transplanted Kidney and Xp11.2 Translocation/Transcription Factor E3-Rearranged Renal Cell Carcinoma in the Native Kidney: A Case Report

  • 김민혜 (고려대학교 의과대학 구로병원 영상의학과) ;
  • 김경아 (고려대학교 의과대학 구로병원 영상의학과) ;
  • 김정우 (고려대학교 의과대학 구로병원 영상의학과) ;
  • 이석영 (고려대학교 의과대학 구로병원 영상의학과) ;
  • 최재웅 (고려대학교 의과대학 구로병원 영상의학과)
  • Min Hye Kim (Department of Radiology, Korea University Guro Hospital) ;
  • Kyeong Ah Kim (Department of Radiology, Korea University Guro Hospital) ;
  • Jeong Woo Kim (Department of Radiology, Korea University Guro Hospital) ;
  • Seok Young Lee (Department of Radiology, Korea University Guro Hospital) ;
  • Jae Woong Choi (Department of Radiology, Korea University Guro Hospital)
  • 투고 : 2023.08.20
  • 심사 : 2023.09.17
  • 발행 : 2024.03.01
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초록

고유신장과 이식신장 모두에 신세포암종이 발생하는 경우는 매우 드물며, 소수의 증례만이 영문 문헌에서 보고되었다. Xp11.2전위/전사인자E3 (이하 TFE3)-재배열 신세포암종은 성인인구에서 드문 아형이다. 신장이식을 받은 어린이에서 TFE3-재배열 신세포암종이 소수의 증례로 보고되었으나, 어른에서 신장이식 후 TFE3-재배열 신세포암종이 보고된 증례는 없다. 저자들은 이식신장에 유두모양 신세포암종이, 고유신장에 TFE3-재배열 신세포암종이 있던 드문 증례를 영상 소견과 함께 보고하고자 한다. 고유신장에 생긴 TFE3-재배열 신세포암종은 5년에 걸쳐 천천히 자랐다. CT에서 약한 조영증강을 보이는 소엽 모양 종괴였으며, MRI에서는 T1 강조영상에서 높은 신호 강도를, T2 강조영상에서 낮은 신호 강도를 보였다.

Concomitant renal cell carcinomas (RCC) of both native and allograft kidneys are extremely rare, and only a few cases have been reported in the available English literature. A particularly rare variant within the adult population is the Xp11.2 translocation/transcription factor E3 (TFE3)-rearranged RCC. Although few case reports of TFE3-rearranged RCC have been reported in children who underwent kidney transplantation (KT), no case of adults with TFE3-rearranged RCC following KT has been reported. Herein, we presented the radiological and pathological findings of a rare metachronous papillary RCC in the allograft kidney and TFE3-rearranged RCC in the native kidney. The TFE3-rearranged RCC in the native kidney exhibited slow expansion in size over five years. Radiologically, it appeared as a slightly enhanced, lobulated mass on contrast-enhanced CT. MRI revealed high signal intensity on T1-weighted images and low signal intensity on T2-weighted images.

키워드

참고문헌

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