DOI QR코드

DOI QR Code

The effect of aromatherapy on pain in individuals with diabetes: a systematic review and meta-analysis

  • Received : 2024.04.25
  • Accepted : 2024.05.10
  • Published : 2024.05.31

Abstract

Purpose: This study systematically analyzed the impact of aromatherapy on pain in individuals with diabetes. Methods: A search was performed in seven electronic databases based on the PICO-SD (Population, Intervention, Comparison, Outcome, Study Design) framework. The population (P) of interest was individuals with diabetes, and the intervention (I) included aromatherapy targeting pain reduction. The comparison (C) consisted of control groups that received no intervention, another intervention, or usual care. The outcome (O) measured was pain. The quality of the selected literature was assessed using the Joanna Briggs Institute checklist. In MIX 2.0 Pro, the pooled overall effect of pain was calculated using Hedge's g and a random-effects model, and heterogeneity was calculated using the Q statistic and Higgin's I2 values. Meta-regression and exclusion sensitivity analyses were performed. Results: Five articles and seven studies were included, showing a significant pooled overall effect of aromatherapy on diabetes-related pain (Hedge's g = -1.83, 95% CI: -2.76 to -0.91). Meta-regression demonstrated that effectiveness in reducing pain was associated with studies conducted in West Asia, those with IRB approval, and those receiving funding. Additionally, interventions involving subjects under 60, lavender oil (vs. turpentine oil or blended oils), massage therapy (vs. topical application), fewer hours per session, and more repeated measurements (vs. pre/post measurements) were associated with pain reduction. Conclusion: Aromatherapy, especially with lavender oil, effectively manages diabetes-related pain. Short-duration massage application is also effective. A personalized selection of oil type and application method could optimize therapeutic outcomes for individuals with diabetes.

Keywords

Acknowledgement

The authors sincerely appreciate the participation of those who participated in this study.

References

  1. Giovannini S, Coraci D, Brau F, Galluzzo V, Loreti C, Caliandro P, et al. Neuropathic pain in the elderly. Diagnostics. 2021; 11(4):613. https://doi.org/10.3390/diagnostics11040613
  2. Kaur S, Pandhi P, Dutta P. Painful diabetic neuropathy: an update. Annals of Neurosciences. 2011;18(4):168-175.
  3. Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJM. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care. 2011;34(10):2220-2224. https://doi.org/10.2337/dc11-1108
  4. Bril V, England J, Franklin GM, Backonja M, Cohen J, Del Toro D, et al. Evidence-based guideline: treatment of painful diabetic neuropathy. Physical Medicine and Rehabilitation. 2011;3(4):345-352. https://doi.org/10.1016/j.pmrj.2011.03.008
  5. Ridouh I, Hackshaw KV. Essential oils and neuropathic pain. Plants. 2022;11(14):1797. https://doi.org/10.3390/plants11141797
  6. Forouzanfar F, Hosseinzadeh H. Medicinal herbs in the treatment of neuropathic pain: a review. Iranian Journal of Basic Medical Sciences. 2018;21(4):347-358.
  7. Kim S, Song JA, Kim ME, Hur MH. Effects of aromatherapy on menopausal symptoms, perceived stress and depression in middle aged women: a systematic review. Journal of Korean Academy of Nursing. 2016;46(5):619-629. https://doi.org/10.4040/jkan.2016.46.5.619
  8. Starkweather A. Aromatherapy: does it make "scents" as complementary therapy in pain management? Topics in Pain Management. 2018;34(1):1-8. https://doi.org/10.1097/01.TPM.0000544120.47075.8e
  9. Jo MJ. The effects of aroma inhalation on stress, fatigue, mood, and vital signs of the nurses in the operating rooms. Korean Journal of Adult Nursing. 2010;22(2):153-160.
  10. Barker TH, Stone JC, Sears K, Klugar M, Tufanaru C, Leonardi-Bee J, et al. The revised JBI critical appraisal tool for the assessment of risk of bias for randomized controlled trials. JBI Evidence Synthesis. 2023;21(3):494-506. https://doi.org/10.11124/JBIES-22-00430
  11. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to meta-analysis. 1st ed. West Sussex: John Wiley & Sons; 2009. https://doi.org/10.1002/9780470743386
  12. Hardy RJ, Thompson SG. Detecting and describing heterogeneity in meta-analysis. Statistics in Medicine. 1998;17(8):841-856. https://doi.org/10.1002/(sici)1097-0258(19980430)17:8%3C841::aid-sim781%3E3.0.co;2-d
  13. Von Hippel PT. The heterogeneity statistic I2 can be biased in small meta-analyses. BMC Medical Research Methodology. 2015;15:35. https://doi.org/10.1186/s12874-015-0024-z
  14. Sterne JAC, Egger M, Moher D. Addressing reporting biases. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of intervention. 2nd ed. London: The Cochrane Collaboration; 2011. https://doi.org/10.1002/9780470712184.ch10
  15. Brydges CR. Effect size guidelines, sample size calculations, and statistical power in gerontology. Innovation in Aging. 2019;3(4):1-8. https://doi.org/10.1093/geroni/igz036
  16. Bown MJ, Sutton AJ. Quality control in systematic reviews and meta-analyses. European Journal of Vascular and Endovascular Surgery. 2010;40:669-677. https://doi.org/10.1016/j.ejvs.2010.07.011
  17. Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455-463. https://doi.org/10.1111/j.0006-341X.2000.00455.x
  18. Edge J. A pilot study addressing the effect of aromatherapy massage on mood, anxiety and relaxation in adult mental health. Complementary Therapies in Nursing and Midwifery. 2003;9:90-97. https://doi.org/10.1016/S1353-6117(02)00104-X
  19. Cha JH, Kim MJ, Kim HS, Kim YI. Effects of aromatherapy in blending oil of basil, lavender, rosemary, and rose on headache, anxiety and serum cortisol level in the middle-aged women. Journal of Korean Biological Nursing Science. 2010;12(2):133-139.
  20. Ko YJ. Effects of lavender fragrance inhalation method on sleep, depression and stress of institutionalized elderly. Journal of East-West Nursing Research. 2012;18(2):74-80. https://doi.org/10.14370/jewnr.2012.18.2.074
  21. Lee EJ, Kim BS, Sa IH, Moon KE, Kim JH. The effects of aromatherapy on sleep disorders, satisfaction of sleep and fatigue in hemodialysis patients. Korean Journal of Adult Nursing. 2011;23(6):615-623.
  22. Ghasemzadeh MR, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Effect of alcoholic extract of aerial parts of Rosmarinus officinalis L. on pain, inflammation and apoptosis induced by chronic constriction injury (CCI) model of neuropathic pain in rats. Journal of Ethnopharmacology. 2016;194:117-130. https://doi.org/10.1016/j.jep.2016.08.043
  23. Gok Metin Z, ArikanDonmez A, Izgu N, Ozdemir L, Arslan IE. Aromatherapy massage for neuropathic pain and quality of life in diabetic patients. Journal of Nursing Scholarship. 2017;49(4):379-388. https://doi.org/10.1111/jnu.12300
  24. Wang CX, Chen SL. Aromachology and its application in the textile field. Fibres & Textiles in Eastern Europe. 2005;6(54):41-44.
  25. Kim JC, Park MA, Kim MJ. Aromatherapy in primary care. Journal of the Korean Academy of Family Medicine. 2002; 23(4):417-429.