대한본초학회지 (The Korea Journal of Herbology)

  • 제39권3호
  • /
  • Pages.23-35
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  • 2024
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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육계 및 기원종별 계피의 지표성분 함량 비교

Quantitative Comparison of Cinnamomi Cortex and Various Cinnamon Barks using HPLC Analysis

  • 김한영 (부산대학교 한의학전문대학원) ;
  • 김정훈 (부산대학교 한의학전문대학원 약물의학교실)
  • Han-Young Kim (School of Korean Medicine, Pusan National University) ;
  • Jung-Hoon Kim (Division of Pharmacology, School of Korean Medicine, Pusan National University)
  • 투고 : 2024.04.03
  • 심사 : 2024.05.25
  • 발행 : 2024.05.30
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초록

Objective : In this study, we performed quantitative comparison on the content of 10 marker compounds in cinnamon barks from different species and found chemical discrimination between genuine Cinnamomum cassia and other Cinnamomum species (Non C. cassia). Methods : Cinnamon bark samples were extracted using the ultrasonication in 100% methanol for 30 minutes. The samples were analysed using high-performance liquid chromatography with statistical analysis. Results : The analytical method developed in this study met all validation criteria and was applied to the quantification of the 10 marker compounds in cinnamon bark samples. The major chemical discrimination of C. cassia were identified as low content of epicatechin and eugenol, and high contents of benzaldehyde, cinnamaldehyde and cinnamic acid compared to other Non C. cassia samples. Especially, among other compounds, the content of cinnamaldehyde was the highest in the C. cassia and Non C. cassia samples. The result of principal component analysis showed that the samples of C. cassia and Non C. cassia were clearly differentiated via benzaldehyde, cinnamaldehyde, cinnamic acid, eugenol, and epicatechin, which influenced on clustering C. cassia and Non C. cassia samples. Conclusion : C. cassia and Non C. cassia samples were chemically discriminated using the quantitative HPLC analysis. Based on this, it is possible to control the quality of herbal medicines containing Cinnamomi Cortex. It is necessary to further improve the accuracy of discrimination between C. cassia and Non C. cassia species to evaluate cinnamon bark quality.

키워드

과제정보

이 과제는 부산대학교 기본연구지원사업(2년)에 의하여 연구되었습니다. 시료를 제공한 한국한의학연구원 한약표준표본관에 감사드립니다.

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