Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
권호 표지
DOI QR코드

DOI QR Code

Rehabilitative goals for patients undergoing lung retransplantation

  • Massimiliano Polastri (Department of Continuity of Care and Integration, Physical Medicine and Rehabilitation, IRCCS Azienda Ospedaliero-Universitaria di Bologna) ;
  • Robert M. Reed (Department of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine)
  • Received : 2024.02.27
  • Accepted : 2024.03.25
  • Published : 2024.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Lung retransplantation (LRT) involves a second or subsequent lung transplant (LT) in a patient whose first transplanted graft has failed. LRT is the only treatment option for irreversible lung allograft failure caused by acute graft failure, chronic lung allograft dysfunction, or postoperative complications of bronchial anastomosis. Prehabilitation (rehabilitation before LT), while patients are on the waiting list, is recognized as an essential component of the therapeutic regimen and should be offered throughout the waiting period from the moment of listing until transplantation. LRT is particularly fraught with challenges, and prehabilitation to reduce frailty is one of the few opportunities to address modifiable risk factors (such as functional and motor impairments) in a patient population in which there is clearly room to improve outcomes. Although rehabilitative outcomes and quality of life in patients receiving or awaiting LT have gained increased interest, there is a paucity of data on rehabilitation in patients undergoing LRT. Frailty is one of the few modifiable risk factors of retransplantation that is potentially preventable. As such, it is imperative that professionals involved in the field of retransplantation conduct research specifically exploring rehabilitative techniques and outcomes of value for patients receiving LRT, because this area remains unexplored.

Keywords

References

  1. Magee JC, Barr ML, Basadonna GP, Johnson MR, Mahadevan S, McBride MA, et al. Repeat organ transplantation in the United States, 1996-2005. Am J Transplant 2007;7(5 Pt 2):1424-33. https://doi.org/10.1111/j.1600-6143.2007.01786.x
  2. Keshavjee S. Retransplantation of the lung comes of age. J Thorac Cardiovasc Surg 2006;132:226-8. https://doi.org/10.1016/j.jtcvs.2006.04.005
  3. Kawut SM. Lung retransplantation. Clin Chest Med 2011;32:367-77. https://doi.org/10.1016/j.ccm.2011.02.013
  4. Aigner C. Retransplantation. Curr Opin Organ Transplant 2015;20:521-6. https://doi.org/10.1097/MOT.0000000000000237
  5. Bedair B, Hachem RR. Management of chronic rejection after lung transplantation. J Thorac Dis 2021;13:6645-53. https://doi.org/10.21037/jtd-2021-19
  6. Rucker AJ, Nellis JR, Klapper JA, Hartwig MG. Lung retransplantation in the modern era. J Thorac Dis 2021;13:6587-93. https://doi.org/10.21037/jtd-2021-25
  7. Michel E, Galen Hartwig M, Sommer W. Lung retransplantation. Thorac Surg Clin 2022;32:259-68. https://doi.org/10.1016/j.thorsurg.2021.12.001
  8. Yusen RD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Goldfarb SB, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Lung and Heart-Lung Transplantation Report--2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant 2015;34:1264-77. https://doi.org/10.1016/j.healun.2015.08.014
  9. Schaheen L, D'Cunha J. Re-do lung transplantation: keys to success. J Thorac Dis 2019;11:5691-3. https://doi.org/10.21037/jtd.2019.12.104
  10. Wallinder A, Danielsson C, Magnusson J, Riise GC, Dellgren G. Outcomes and long-term survival after pulmonary retransplantation: a single-center experience. Ann Thorac Surg 2019; 108:1037-44. https://doi.org/10.1016/j.athoracsur.2019.04.028
  11. Kon ZN, Bittle GJ, Pasrija C, Sanchez PG, Griffith BP, Pierson RN 3rd. The optimal procedure for retransplantation after single lung transplantation. Ann Thorac Surg 2017;104:170-5. https://doi.org/10.1016/j.athoracsur.2016.10.002
  12. Harhay MO, Cherikh WS, Toll AE, Christie JD, Stehlik J, Chambers D, et al. Epidemiology, risk factors, and outcomes of lung retransplantation: an analysis of the International Society for Heart and Lung Transplantation Thoracic Transplant Registry. J Heart Lung Transplant 2022;41:1478-86. https://doi.org/10.1016/j.healun.2022.06.022
  13. Hayanga JW, Aboagye JK, Hayanga HK, Luketich JD, D'Cunha J. Extracorporeal membrane oxygenation as a bridge to lung re-transplantation: is there a role? J Heart Lung Transplant 2016;35:901-5. https://doi.org/10.1016/j.healun.2016.02.006
  14. Warnecke G, Haverich A. Lung re-transplantation: review. Curr Opin Organ Transplant 2012;17:485-9. https://doi.org/10.1097/MOT.0b013e328357d8ba
  15. Annema C, De Smet S, Castle EM, Overloop Y, Klaase JM, Janaudis-Ferreira T, et al. European Society of Organ Transplantation (ESOT) consensus statement on prehabilitation for solid organ transplantation candidates. Transpl Int 2023;36:11564.
  16. Jutagir DR, Saracino RM, Cunningham A, Foran-Tuller KA, Driscoll MA, Sledge WH, et al. The feasibility of a group stress management Liver SMART intervention for patients with end-stage liver disease: a pilot study. Palliat Support Care 2019;17:35-41. https://doi.org/10.1017/S147895151800024X
  17. Pereira RO, Rodrigues ES, Martin AK, Narula T, Ball CT, Alvarez F, et al. Outcomes after lung retransplantation: a single-center retrospective cohort study. J Cardiothorac Vasc Anesth 2022;36:1366-72. https://doi.org/10.1053/j.jvca.2021.08.025
  18. Randhawa SK, Yang Z, Morkan DB, Yan Y, Chang SH, Hachem RR, et al. One-year survival worse for lung retransplants relative to primary lung transplants. Ann Thorac Surg 2022;113:1265-73. https://doi.org/10.1016/j.athoracsur.2021.03.112
  19. Chambers DC, Perch M, Zuckermann A, Cherikh WS, Harhay MO, Hayes D Jr, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics. J Heart Lung Transplant 2021;40:1060-72. https://doi.org/10.1016/j.healun.2021.07.021
  20. Novick RJ, Stitt LW, Al-Kattan K, Klepetko W, Schafers HJ, Duchatelle JP, et al. Pulmonary retransplantation: predictors of graft function and survival in 230 patients. Pulmonary Retransplant Registry. Ann Thorac Surg 1998;65:227-34. https://doi.org/10.1016/S0003-4975(97)01191-0
  21. Aigner C, Jaksch P, Taghavi S, Lang G, Reza-Hoda MA, Wisser W, et al. Pulmonary retransplantation: is it worth the effort?: a long-term analysis of 46 cases. J Heart Lung Transplant 2008; 27:60-5. https://doi.org/10.1016/j.healun.2007.09.023
  22. Kilic A, Beaty CA, Merlo CA, Conte JV, Shah AS. Functional status is highly predictive of outcomes after redo lung transplantation: an analysis of 390 cases in the modern era. Ann Thorac Surg 2013;96:1804-11. https://doi.org/10.1016/j.athoracsur.2013.05.080
  23. Polastri M, Dell'Amore A, Eden A, Pehlivan E. Does preoperative rehabilitation influence the quality of life in patients who are candidates for lung transplant? Exp Clin Transplant 2022; 20:543-8. https://doi.org/10.6002/ect.2022.0039
  24. Polastri M, Dell'Amore A, Reed RM, Pehlivan E. Handgrip strength in lung transplant candidates and recipients. Exp Clin Transplant 2023;21:547-55.
  25. Polastri M, Paganelli GM, Dolci G, Di Ciaccio E, Prediletto I. Musculoskeletal syndrome treated with global postural re-education in double-redo lung transplantation: a case report with an 8-month follow-up. Reumatismo 2022;74:29-35. https://doi.org/10.4081/reumatismo.2022.1386
  26. Wickerson L, Rozenberg D, Janaudis-Ferreira T, Deliva R, Lo V, Beauchamp G, et al. Physical rehabilitation for lung transplant candidates and recipients: an evidence-informed clinical approach. World J Transplant 2016;6:517-31. https://doi.org/10.5500/wjt.v6.i3.517
  27. Quint EE, Ferreira M, van Munster BC, Nieuwenhuijs-Moeke G, Te Velde-Keyzer C, Bakker SJ, et al. Prehabilitation in adult solid organ transplant candidates. Curr Transplant Rep 2023;10:70-82. https://doi.org/10.1007/s40472-023-00395-4
  28. Polastri M. Physiotherapy for lung transplant candidates and recipients: time frame from pre-operative to long-term care. Int J Ther Rehabil 2019;26:1-6. https://doi.org/10.12968/ijtr.2019.0147
  29. Vendetti ML, Esther Moon SJ, Imes CC, Hergenroeder A, Sciurba F, Lendermon E, et al. Design of Lung Transplant Go (LTGO): a randomized controlled trial evaluating the efficacy of a telerehabilitation behavioral exercise intervention to improve physical activity, physical function, and blood pressure control after lung transplantation. Contemp Clin Trials Commun 2023;33:101097.
  30. Layton AM, Irwin AM, Mihalik EC, Fleisch E, Keating CL, DiMango EA, et al. Telerehabilitation using fitness application in patients with severe cystic fibrosis awaiting lung transplant: a pilot study. Int J Telemed Appl 2021;2021:6641853.
  31. Wickerson L, Helm D, Gottesman C, Rozenberg D, Singer LG, Keshavjee S, et al. Telerehabilitation for lung transplant candidates and recipients during the COVID-19 pandemic: program evaluation. JMIR Mhealth Uhealth 2021;9:e28708.
  32. Pehlivan E, Mutluay F, Balci A, Kilic L. The effects of inspiratory muscle training on exercise capacity, dyspnea and respiratory functions in lung transplantation candidates: a randomized controlled trial. Clin Rehabil 2018;32:1328-39. https://doi.org/10.1177/0269215518777560
  33. Li M, Mathur S, Chowdhury NA, Helm D, Singer LG. Pulmonary rehabilitation in lung transplant candidates. J Heart Lung Transplant 2013;32:626-32. https://doi.org/10.1016/j.healun.2013.04.002
  34. Hume E, Ward L, Wilkinson M, Manifield J, Clark S, Vogiatzis I. Exercise training for lung transplant candidates and recipients: a systematic review. Eur Respir Rev 2020;29:200053.
  35. Gloeckl R, Halle M, Kenn K. Interval versus continuous training in lung transplant candidates: a randomized trial. J Heart Lung Transplant 2012;31:934-41. https://doi.org/10.1016/j.healun.2012.06.004
  36. Fuller LM, Button B, Tarrant B, Steward R, Bennett L, Snell G, et al. Longer versus shorter duration of supervised rehabilitation after lung transplantation: a randomized trial. Arch Phys Med Rehabil 2017;98:220-6. https://doi.org/10.1016/j.apmr.2016.09.113
  37. Langer D, Burtin C, Schepers L, Ivanova A, Verleden G, Decramer M, et al. Exercise training after lung transplantation improves participation in daily activity: a randomized controlled trial. Am J Transplant 2012;12:1584-92. https://doi.org/10.1111/j.1600-6143.2012.04000.x
  38. Ihle F, Neurohr C, Huppmann P, Zimmermann G, Leuchte H, Baumgartner R, et al. Effect of inpatient rehabilitation on quality of life and exercise capacity in long-term lung transplant survivors: a prospective, randomized study. J Heart Lung Transplant 2011;30:912-9. https://doi.org/10.1016/j.healun.2011.02.006
  39. Rodrigue JR, Baz MA, Widows MR, Ehlers SL. A randomized evaluation of quality-of-life therapy with patients awaiting lung transplantation. Am J Transplant 2005;5:2425-32. https://doi.org/10.1111/j.1600-6143.2005.01038.x
  40. Weber Gulling M, Schaefer M, Bishop-Simo L, Keller BC. Optimizing nutrition assessment to create better outcomes in lung transplant recipients: a review of current practices. Nutrients 2019;11:2884.
  41. Staufer K, Halilbasic E, Hillebrand P, Harm S, Schwarz S, Jaksch P, et al. Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis. United European Gastroenterol J 2018;6:1049-55. https://doi.org/10.1177/2050640618778381
  42. Nonaka PN, Uriarte JJ, Campillo N, Oliveira VR, Navajas D, Farre R. Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ. Respir Res 2016;17:161.
  43. Uriarte JJ, Uhl FE, Rolandsson Enes SE, Pouliot RA, Weiss DJ. Lung bioengineering: advances and challenges in lung decellularization and recellularization. Curr Opin Organ Transplant 2018;23:673-8. https://doi.org/10.1097/MOT.0000000000000584
  44. Ebenbichler G, Doblhammer S, Pachner M, Habenicht R, Kienbacher T, Mair P, et al. Impairments in postural control and retest reliability of dynamic posturographic measures after lung transplantation. Am J Phys Med Rehabil 2019;98:353-9. https://doi.org/10.1097/PHM.0000000000001095