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The Nevus Lipomatosus Superficialis of Face: A Case Report and Literature Review

  • Received : 2023.08.03
  • Accepted : 2023.11.24
  • Published : 2024.03.15

Abstract

Nevus lipomatosus superficialis (NLS) is a hamartoma of adipose tissue, rarely reported in the past 100 years. We treated one case, and we conducted a systematic review of the literature. A 41-year-old man presented with a cutaneous multinodular lesion in the posterior region near the right auricle. The lesion was excised and examined histopathologically. To review the literature, we searched PubMed with the keyword "NLS." The search was limited to articles written in English and whose full text was available. We analyzed the following data: year of report, nation of corresponding author, sex of patient, age at onset, duration of disease, location of lesion, type of lesion, associated symptoms, pathological findings, and treatment. Of 158 relevant articles in PubMed, 112 fulfilled our inclusion criteria; these referred to a total of 149 cases (cases with insufficient clinical information were excluded). In rare cases, the diagnosis of NLS was confirmed when the lesion coexisted with sebaceous trichofolliculoma and Demodex infestation. Clinical awareness for NLS has increased recently. NLS is an indolent and asymptomatic benign neoplasm that may exhibit malignant behavior in terms of huge lesion size and specific anatomical location. Early detection and curative treatment should be promoted.

Keywords

References

  1. Lynch FW, Goltz RW. Nevus lipomatosus cutaneus superficialis (Hoffmann-Zurhelle); presentation of a case and review of the literature. AMA Arch Derm 1958;78(04):479-482  https://doi.org/10.1001/archderm.1958.01560100055008
  2. Pursley TV. Nevus lipomatosus cutaneous superficialis. Int J Dermatol 1983;22(07):430-431  https://doi.org/10.1111/j.1365-4362.1983.tb02165.x
  3. Rare Diseases Clinical Research Network. How rare is rare? Cincinnati, OH: Cincinnati Children's Hospital Medical Center. Accessed July 21, 2023 at: https://www.rarediseasesnetwork.org/about/what-are-rare-diseases 
  4. Lee IJ, Lee SH. Familial case of nevus lipomatosus superficialis. Ann Dermatol 1995;7:88-92  https://doi.org/10.5021/ad.1995.7.1.88
  5. Dhamija A, Meherda A, D'Souza P, Meena RS. Nevus lipomatosus cutaneous superficialis: an unusual presentation. Indian Dermatol Online J 2012;3(03):196-198  https://doi.org/10.4103/2229-5178.101819
  6. Cardot-Leccia N, Italiano A, Monteil MC, Basc E, Perrin C, Pedeutour F. Naevus lipomatosus superficialis: a case report with a 2p24 deletion. Br J Dermatol 2007;156(02):380-381  https://doi.org/10.1111/j.1365-2133.2006.07622.x
  7. Tuncer S, Sezgin B, Yilmaz G, Gocun PU, Kucuker I. Compression neuropathy caused by an unusual lesion: nevus lipomatosus cutaneus superficialis. Plast Reconstr Surg 2011;127(03):72e-74e  https://doi.org/10.1097/PRS.0b013e31820633fb
  8. Jung ST, Park HW, Yun SJ. Giant nevus lipomatosus cutaneous superficialis with intramuscular lipomatosis. J Am Acad Dermatol 2012;67(04):e168-e170  https://doi.org/10.1016/j.jaad.2012.01.025
  9. Tas S, Top H. Giant nevus lipomatosus cutaneous superficialis with intramuscular lipomatosis caused sciatic nerve compression. J Cutan Med Surg 2014;18(04):221-222  https://doi.org/10.2310/7750.2013.13161
  10. Maeda A, Aragane Y, Ueno K, Yamazaki F, Kawada A, Tezuka T. A case of naevus lipomatosus cutaneus superficialis of the scalp associated with pedunculated basal cell carcinoma. Br J Dermatol 2003;148(05):1084-1086  https://doi.org/10.1046/j.1365-2133.2003.05196.x
  11. Bancalari E, Martinez-Sanchez D, Tardio JC. Nevus lipomatosus superficialis with a folliculosebaceous component: report of 2 cases. Pathol Res Int 2011;2011:105973 
  12. Kim EJJS, Jo SJ, Cho KH. A case of mucinous nevus clinically mimicking nevus lipomatosus superficialis. Ann Dermatol 2014;26(04):549-550  https://doi.org/10.5021/ad.2014.26.4.549
  13. Adotama P, Hutson SD, Rieder EA, Stein JA, Kim RH. Revisiting solitary pedunculated lipofibromas. Am J Clin Pathol 2021;156(06):954-957  https://doi.org/10.1093/ajcp/aqab075
  14. Fatah S, Ellis R, Seukeran DC, Carmichael AJ. Successful CO2 laser treatment of naevus lipomatosus cutaneous superficialis. Clin Exp Dermatol 2010;35(05):559-560  https://doi.org/10.1111/j.1365-2230.2010.03794.x
  15. Sardana K, Bansal S, Garg VK, Khurana N. Treatment of Nevus lipomatosus cutaneous superficialis with CO2 laser. J Cosmet Dermatol 2017;16(03):333-335  https://doi.org/10.1111/jocd.12327
  16. Ruray RR, Djawad K, Nurdin A. Nevus lipomatosus cutaneous superficialis with a histopathological appearance resembling sclerotic fibroma: a rare case report. Open Access Maced J Med Sci 2021;9:246-249  https://doi.org/10.3889/oamjms.2021.7510
  17. de Paula Mesquita T, de Almeida HL Jr, de Paula Mesquita MC. Histologic resolution of naevus lipomatosus superficialis with intralesional phosphatidylcholine. J Eur Acad Dermatol Venereol 2009;23(06):714-715  https://doi.org/10.1111/j.1468-3083.2008.03005.x
  18. Castagna RD, Benvegnu AM, Dallazem LND, Brutti CS. Topical corticosteroid therapy: a treatment option for nevus lipomatosus cutaneous superficialis? An Bras Dermatol 2018;93(01):158-159  https://doi.org/10.1590/abd1806-4841.20186986
  19. Ancer-Arellano J, Villarreal-Villarreal CD, Cardenas-de la Garza JA, Cuellar-Barboza A, Vazquez-Martinez O, Ocampo-Candiani J. Electrodissection for nevus lipomatosus cutaneous superficialis removal. J Am Acad Dermatol 2019;81(05):e127-e128 https://doi.org/10.1016/j.jaad.2018.11.051