Journal of Periodontal and Implant Science

  • 제54권1호
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  • Pages.37-43
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  • 2024
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
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Measurement of atherosclerosis markers in individuals with periodontitis

  • Angar Soronzonbold (School of Dentistry, Mongolian National University of Medical Sciences) ;
  • Erkhbilguun Munkhkherlen (School of Dentistry, Mongolian National University of Medical Sciences) ;
  • Khongorzul Batchuluun (Department of Histology, School of Biomedicine, Mongolian National University of Medical Sciences) ;
  • Oyun-Enkh Puntsag (Department of Periodontics and Endodontics, School of Dentistry, Mongolian National University of Medical Sciences) ;
  • Uurtuya Shuumarjav (Institute of Biomedical Sciences, Mongolian National University of Medical Sciences) ;
  • Bayarchimeg Batbayar (Department of Periodontics and Endodontics, School of Dentistry, Mongolian National University of Medical Sciences)
  • 투고 : 2022.10.31
  • 심사 : 2023.04.30
  • 발행 : 2024.02.28
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초록

Purpose: The inflammatory response due to inflammatory cytokines, bacterial pathogens, and the altered lipoprotein metabolism in patients with periodontitis indicates that infection with periodontal anaerobic bacteria may influence atherogenesis in vitro and in vivo. We aimed to explore the effect of periodontitis concerning clinical and ultrasound markers of early atherosclerosis. Methods: In this case-control study, a total of 30 systemically healthy adults (15 with periodontitis and 15 without periodontitis) over 40 years of age were studied. Periodontitis was determined by measuring the clinical attachment level (CAL) and radiographic bone loss (RBL). Conventional cardiovascular risk factors, including body mass index, serum levels of total cholesterol (TCH), triglycerides (TG), and high-density and low-density lipoprotein (HDL and LDL, respectively) cholesterol were evaluated. Carotid artery intima-media thickness (IMT) was measured using ultrasonography. Results: The mean values of the CAL and carotid IMT were 5.02±0.9 mm and 0.084±0.01 cm vs. 1.6±0.61 mm and 0.072±0.02 cm in the periodontitis and healthy groups, respectively, reflecting statistically significant differences (P=0.001 and P=0.037, respectively). There were statistically significant differences in the serum levels of TCH, TG, and LDL between the 2 groups (P=0.017). The CAL and RBL were positively associated with carotid IMT and serum cholesterol levels, except for HDL, whereas tooth loss was not associated with any markers (P<0.05). Compared to the healthy group, participants with periodontitis exhibited 2.09 times higher odds (95% confidence interval, 1.22-3.59) of having subclinical atherosclerosis. Conclusions: The presence of periodontitis increased the risk of atherosclerosis.

키워드

과제정보

We gratefully acknowledge all the research team members, "Tujdent" dental clinic, and the School of Dentistry, Mongolian National University of Medical Sciences.

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