Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지
DOI QR코드

DOI QR Code

Burning measure for burning mouth syndrome: a systematic review

  • Sunny Priyatham Tirupathi (Department of Pediatric and Preventive Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University) ;
  • Sardhar Malothu (Department of Periodontics, Mamatha Dental College & Hospital) ;
  • Udaikiran Allaparthi (Department of Public Health Dentistry, Sri Balaji Dental College) ;
  • Swathi Velvaluri (Department of Periodontics, Kalinga Institute of Dental Sciences) ;
  • Lamea Afnan (Department of Public Health Dentistry, Coorg Institute of Dental Sciences) ;
  • Shraddha Budia (Consultant Pediatric Dentist) ;
  • Muskaan Sachdev (Clinical Documentation Specialist, IKS Health Pvt. Ltd.)
  • Received : 2023.01.28
  • Accepted : 2023.03.23
  • Published : 2024.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

This current systematic review aimed to evaluate the current evidence on the effect of topical capsaicin application to alleviate symptoms related to burning mouth syndrome (BMS). PubMed, Ovid SP, and Cochrane were searched from 1980 to 2022 to identify relevant literature. A total of 942 titles (PubMed, 84; Ovid SP, 839; Cochrane, 19) was retrieved, of which 936 were excluded based on the title and abstract. A total of 11 studies were further evaluated for full text analysis, of which 7 were excluded. As a result, 4 articles were included for qualitative synthesis of data. Capsaicin as a mouthwash can have potential application in the treatment of symptoms related to burning mouth. The quality of available studies is moderate to low, and a well-designed randomized multicentric study comparing capsaicin with other active agents is planned to obtain more definitive conclusions.

Keywords

References

  1. Khawaja SN, Alaswaiti OF, Scrivani SJ. Burning mouth syndrome. Dent Clin North Am 2023;67:49-60. https://doi.org/10.1016/j.cden.2022.07.004 
  2. Wu S, Zhang W, Yan J, Noma N, Young A, Yan Z. Worldwide prevalence estimates of burning mouth syndrome: a systematic review and meta-analysis. Oral Dis 2022;28:1431-40. https://doi.org/10.1111/odi.13868 
  3. Albuquerque RJC, de Leeuw R, Carlson CR, Okeson JP, Miller CS, Andersen AH. Cerebral activation during thermal stimulation of patients who have burning mouth disorder: an fMRI study. Pain 2006;122:223-34. https://doi.org/10.1016/j.pain.2006.01.020 
  4. Jaaskelainen SK, Forssell H, Tenovuo O. Abnormalities of the blink reflex in burning mouth syndrome. Pain 1997;73:455-60. https://doi.org/10.1016/s0304-3959(97)00140-1 
  5. Forssell H, Jaaskelainen S, Tenovuo O, Hinkka S. Sensory dysfunction in burning mouth syndrome. Pain 2002;99:41-7. https://doi.org/10.1016/s0304-3959(02)00052-0 
  6. Hagelberg N, Forssell H, Rinne JO, Scheinin H, Taiminen T, Aalto S, et al. Striatal dopamine D1 and D2 receptors in burning mouth syndrome. Pain 2003;101:149-54. https://doi.org/10.1016/s0304-3959(02)00323-8 
  7. Lauria G, Majorana A, Borgna M, Lombardi R, Penza P, Padovani A, et al. Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome. Pain 2005;115:332-7. https://doi.org/10.1016/j.pain.2005.03.028 
  8. Marino R, Torretta S, Capaccio P, Pignataro L, Spadari F. Different therapeutic strategies for burning mouth syndrome: preliminary data. J Oral Pathol Med 2010;39:611-6. https://doi.org/10.1111/j.1600-0714.2010.00922.x 
  9. Galli F, Lodi G, Sardella A, Vegni E. Role of psychological factors in burning mouth syndrome: a systematic review and meta-analysis. Cephalalgia 2017;37:265-77. https://doi.org/10.1177/0333102416646769 
  10. Wu YH, Wu YC, Chang JY, Lang MJ, Chiang CP, Sun A. Anemia, hematinic deficiencies, and hyperhomocysteinemia in younger and older burning mouth syndrome patients. J Dent Sci 2022;17:1144-50. https://doi.org/10.1016/j.jds.2022.02.005 
  11. Russo M, Crafa P, Franceschi M, Rodriguez-Castro KI, Franzoni L, Guglielmetti S, et al. Burning mouth syndrome and reflux disease: relationship and clinical implications. Acta Biomed 2022;93:e2022329. https://doi.org/10.23750/abm.v93i6.13391 
  12. Tan HL, Smith JG, Hoffmann J, Renton T. A systematic review of treatment for patients with burning mouth syndrome. Cephalalgia 2022;42:128-61. https://doi.org/10.1177/03331024211036152 
  13. Rumsfield JA, West DP. Topical capsaicin in dermatologic and peripheral pain disorders. DICP 1991;25:381-7. https://doi.org/10.1177/106002809102500409 
  14. Boyd K, Shea SM, Patterson JW. The role of capsaicin in dermatology. Prog Drug Res 2014;68:293-306. https://doi.org/10.1007/978-3-0348-0828-6_12 
  15. Petruzzi M, Lauritano D, De Benedittis M, Baldoni M, Serpico R. Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study. J Oral Pathol Med 2004;33:111-4. https://doi.org/10.1111/j.1600-0714.2004.0194n.x 
  16. Azzi L, Croveri F, Pasina L, Porrini M, Vinci R, Manfredini M, et al. A "burning therapy" for burning mouth syndrome: preliminary results with the administration of topical capsaicin. J Biol Regul Homeost Agents 2017;31(2 Suppl 1):89-95. 
  17. Epstein JB, Marcoe JH. Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 1994;77:135-40. https://doi.org/10.1016/0030-4220(94)90275-5 
  18. Peppin JF, Pappagallo M. Capsaicinoids in the treatment of neuropathic pain: a review. Ther Adv Neurol Disord 2014;7:22-32. https://doi.org/10.1177/1756285613501576 
  19. Romero V, Lara JR, Otero-Espinar F, Salgado MH, Modolo NSP, de Barros GAM. Capsaicin topical cream (8%) for the treatment of myofascial pain syndrome. Rev Bras Anestesiol 2019;69:432-8. https://doi.org/10.1016/j.bjane.2019.06.008 
  20. Scardina GA, Carini F, Valenza V, Messina P. Topical capsaicin application and axon reflex vasodilatation of the tongue: neurogenic involvement in burning mouth syndrome. Methods Find Exp Clin Pharmacol 2006;28:707-11. https://doi.org/10.1358/mf.28.10.1037499 
  21. Teixeira MJ, Menezes LM, Silva V, Galhardoni R, Sasson J, Okada M, et al. Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study. Arq Neuropsiquiatr 2015;73:237-40. https://doi.org/10.1590/0004-282x20140232 
  22. Jankovskis V, Selga G. Vitamin B and zinc supplements and capsaicin oral rinse treatment options for burning mouth syndrome. Medicina (Kaunas) 2021;57:391. https://doi.org/10.3390/medicina57040391 
  23. Jorgensen MR, Pedersen AM. Analgesic effect of topical oral capsaicin gel in burning mouth syndrome. Acta Odontol Scand 2017;75:130-6. https://doi.org/10.1080/00016357.2016.1269191 
  24. Ricken CM, Peder SNS, Kamikawa DS, Pieralisi N, Chicarelli M, Tolentino ES. Evaluation of a protocol for topical application of capsaicine gel 0.025 % in the management of burning mouth syndrome correlating its impact on quality of life. Int J Odontostomatol 2021;15:443-8.  https://doi.org/10.4067/S0718-381X2021000200443
  25. Silvestre FJ, Silvestre-Rangil J, Tamarit-Santafe C, Bautista D. Application of a capsaicin rinse in the treatment of burning mouth syndrome. Med Oral Patol Oral Cir Bucal 2012;17:e1-4. https://doi.org/10.4317/medoral.17219