The Korean Journal of Physiology and Pharmacology

  • 제28권3호
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  • Pages.229-237
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  • 2024
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Pectolinarigenin ameliorated airway inflammation and airway remodeling to exhibit antitussive effect

  • Quan He (Department of Respiratory and Critical Care Medicine, Zhenjiang Hospital of Integrated Traditional Chinese and Western Medicine) ;
  • Weihua Liu (Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Nanjing Medical University) ;
  • Xiaomei Ma (Department of Respiratory and Critical Care Medicine, Zhenjiang Hospital of Integrated Traditional Chinese and Western Medicine) ;
  • Hongxiu Li (Department of Neurology, Zhenjiang Hospital of Integrated Traditional Chinese and Western Medicine) ;
  • Weiqi Feng (Department of Respiratory and Critical Care Medicine, Zhenjiang Hospital of Integrated Traditional Chinese and Western Medicine) ;
  • Xuzhi Lu (Department of Respiratory and Critical Care Medicine, Zhenjiang Hospital of Integrated Traditional Chinese and Western Medicine) ;
  • Ying Li (Department of Clinical Laboratory, Zhenjiang Hospital of Integrated Traditional Chinese and Western Medicine) ;
  • Zi Chen (Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Nanjing Medical University)
  • 투고 : 2023.08.31
  • 심사 : 2024.02.15
  • 발행 : 2024.05.01
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초록

Cough is a common symptom of several respiratory diseases. However, frequent coughing from acute to chronic often causes great pain to patients. It may turn into cough variant asthma, which seriously affects people's quality of life. For cough treatment, it is dominated by over-the-counter antitussive drugs, such as asmeton, but most currently available antitussive drugs have serious side effects. Thus, there is a great need for the development of new drugs with potent cough suppressant. BALB/c mice were used to construct mice model with cough to investigate the pharmacological effects of pectolinarigenin (PEC). Hematoxylin-eosin and Masson staining were used to assess lung injury and airway remodeling, and ELISA was used to assess the level of inflammatory factor release. In addition, inflammatory cell counts were measured to assess airway inflammation. Airway hyperresponsiveness assay was used to assess respiratory resistance in mice. Finally, we used Western blotting to explore the potential mechanisms of PEC. We found that PEC could alleviate lung tissue injury and reduce the release of inflammatory factors, inhibit of cough frequency and airway wall collagen deposition in mice model with cough. Meanwhile, PEC inhibited the Ras/ERK/c-Fos pathway to exhibit antitussive effect. Therefore, PEC may be a potential drug for cough suppression.

키워드

과제정보

This work was supported by the Jiangsu Senile Health Research Project (Grant No. LK2021057), Zhenjiang Key Research and Development Project (Grant No. SH2022081), TCM Science and Technology Development Program of Jiangsu Province (Grant No. MS2022125), and Zhenjiang Key Research and Development Project (Grant No. SH2023034), Jiangsu Province Postgraduate Research and Practice Innovation Program (Grant No. JX10214039).

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