Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Trend in Measles Seroprevalence in the Western Pacific Region: A Systematic Review

  • Ji Won Park (Department of Pediatrics, Korea University Anam Hospital) ;
  • Young June Choe (Department of Pediatrics, Korea University Anam Hospital)
  • Received : 2023.03.24
  • Accepted : 2024.01.21
  • Published : 2024.04.25
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Abstract

Despite improvements in vaccine coverage, a resurgence of measles has been reported, especially in the infant and adult populations in recent years. We conducted a systematic review of seroprevalence studies conducted in the Western Pacific Region (WPR) to provide insights into seropositivity trends in different countries. This systematic review aimed to collect data from all available measles seroprevalence studies to characterize the differences in population immunity against measles in different countries. We searched the online databases PubMed and Embase to identify: 1) observational studies that investigated seroprevalence in all age groups, and 2) results reported as antibody levels. The following variables were extracted from different study arms: paper identification (title, first author, publication year), inclusion and exclusion criteria, study site, age of subjects, number of subjects, country/area, population, methods, and seropositivity (%). The search yielded a total of 69 studies included in the review. Among the 1-6-year-old group, seropositivity remained relatively high, at 81-100% in China, 86-94% in Korea, and 77-91% in Australia. In adolescents aged 7-18-years old, seropositivity was relatively constant in China and Australia over time; however, a decreasing trend was noted in Korea in 2011 (66%), 2014 (69%), and 2014 (50%) in this age group. A similar downward trend was observed among Korean adults aged 19-39 years in 2011 (74%), 2019 (71%), and 2019 (64%). Children are likely to be protected by universal vaccination programs in WPR countries and regions. However, susceptible individuals with waned immunity may be present among the adult population.

홍역의 예방을 위한 백신이 도입되었음에도 불구하고, 최근 십수년 간 영유아 및 성인 인구에서 홍역 발생이 지속되고 있다. 본 종설에서는 서태평양지역(Western Pacific Region, WPR)에서 수행되었던 홍역 항체양성도 연구들을 체계적으로 검토하여 홍역에 대한 집단면역도의 추이를 평가하고자 하였다. 서태평양지역에서 수행된 항체양성도 연구에서 도출된 전 연령대의 항체 유병율을 조사한 관찰 연구를 탐색하기 위해 온라인 데이터베이스 PubMed과 Embase를 검색하였다. 다음 변수들이 서로 다른 연구군에서 추출되다: 논문 식별자(제목, 제1 저자, 발행 연도), 포함 및 제외 기준, 연구 장소, 대상 연령, 대상 수, 국가/지역, 인구, 방법 및 혈청양성도(%). 검색 결과, 총 69건의 연구가 포함되었다. 1-6세 연령 그룹 중에서의 항체양성도는 중국이 81-100%로, 한국 86-94%로, 호주 77-91%로 상대적으로 높게 나타났다. 7-18세 청소년에서는 중국과 호주에서의 양성도는 시간이 지나도 상대적으로 일정하게 유지되었지만, 한국에서는 2011년(66%), 2014년(69%), 2014년(50%) 등으로 감소하는 추세가 있었다. 비슷한 하향 추세가 한국 성인 인구 중 19-39세에서 2011년(74%), 2019년(71%), 2019년(64%)에서도 관찰되었다.

Keywords

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