대한의생명과학회지 (Biomedical Science Letters)

  • 제30권1호
  • /
  • Pages.32-35
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  • 2024
  • /
  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
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Antibacterial activity of Chamaecyparis obtuse Extract and Profile of Antimicrobial Agents Resistance for Methicillin-Resistant Staphylococcus aureus

  • Jong Hwa Yum (Department of Clinical Laboratory Science, Dongeui University)
  • 투고 : 2024.01.11
  • 심사 : 2024.02.05
  • 발행 : 2024.03.31
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초록

In vitro antimicrobial activities of hot water extracts of Chamaecyparis obtuse, for methicillin-resistant Staphylococcus aureus (MRSA) was compared to commonly used conventional antimicrobial agents. All MRSA was susceptible to linezolid or vancomycin, but also to erythromycin. MIC range and MIC90 to erythromycin, clindamycin, levofloxacin, tetracycline for MRSA were each 4 ㎍/mL, 2 ~ >128 ㎍/mL, ≤0.06 ~ >128 ㎍/mL, 0.25 ~ >128 ㎍/mL, 0.25~64 ㎍/mL and 4 ㎍/mL, .128 ㎍/mL, >128 ㎍/mL, >128 ㎍/mL, 64 ㎍/mL. The hot water extracts of leaf of C. obtuse had the lowest MIC range, MIC50, and MIC90 (0.125 µL/mL) for the MRSA tested, and it was possible more potent than various conventional antimicrobial agents. Screen antibacterial drug candidate with high antibacterial activity such as derivatives of C. obtuse leaf extract such as terpinen-4-ol or using combined therapy with commercialized antibacterial agents will likely be helpful in treating refractory MRSA infections.

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과제정보

This work was supported by Dong-eui University foundation grant 2022, I thank professor Jeong-Hwan Shin of Inje University Busan Paik Hospital for his help in collecting strains.

참고문헌

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