Journal of Korean Biological Nursing Science

Korean society of Biological Nursing Science (한국기초간호학회)
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Exercise and adults with hemophilia: a systematic review and meta-analysis

성인 혈우병 환자와 운동: 체계적 문헌고찰과 메타분석

  • Doo Young Kim (College of Nursing, Gyeongsang National University) ;
  • Mi Yang Jeon (College of Nursing, Gerontological Health Research Center in Institute of Health Science, Gyeongsang National University) ;
  • Young Eun (College of Nursing, Gerontological Health Research Center in Institute of Health Science, Gyeongsang National University) ;
  • Da In Jeong (College of Nursing, University of Illinois)
  • 김두영 (경상국립대학교 간호대학) ;
  • 전미양 (경상국립대학교 간호대학.건강과학연구원 노인건강연구센터) ;
  • 은영 (경상국립대학교 간호대학.건강과학연구원 노인건강연구센터) ;
  • 정다인 (일리노이주립대 간호대학)
  • Received : 2023.10.23
  • Accepted : 2024.01.22
  • Published : 2024.02.28
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Abstract

Purpose: This study aimed to evaluate the effectiveness of exercise in patients with hemophilia. Methods: We carried out a systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. A literature search was conducted of published randomized controlled trials for exercise interventions from January 1, 2014 to March 15, 2023. To estimate the size of the effects of exercise, a meta-analysis was performed using the R package "meta." Results: Five databases were searched to obtain articles published in Korean or English. Of 1,150 articles reviewed, 13 were included in the systematic review and 9 in the meta-analysis. The risk of bias was assessed using RoB 2.0. The overall effect sizes of exercise interventions, calculated as the standardized mean difference, were -0.11 (95% confidence interval [CI] = -1.41 to -1.20) for pain, -2.13 (95% CI = -3.33 to -0.93) for joint health, 9.96 (95% CI = 7.51 to 12.28) for physical activity, and 0.59 (95% CI = -0.39 to -1.56) for quality of life. Conclusion: These findings suggest that exercise is useful for improving the joint health and physical activity of patients with hemophilia. Thus, it is necessary to develop and apply exercise interventions for patients with hemophilia to reduce their pain and improve their quality of life.

Keywords

References

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