The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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The role of 27-hydroxycholesterol in meta-inflammation

  • Yonghae Son (Department of Pharmacology, School of Medicine, Pusan National University) ;
  • Eunbeen Choi (Department of Medicine, School of Medicine, Pusan National University) ;
  • Yujin Hwang (Department of Medicine, School of Medicine, Pusan National University) ;
  • Koanhoi Kim (Department of Pharmacology, School of Medicine, Pusan National University)
  • Received : 2023.11.17
  • Accepted : 2024.01.09
  • Published : 2024.03.01
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Abstract

27-Hydroxycholesterol (27OHChol), a prominent cholesterol metabolite present in the bloodstream and peripheral tissues, is a kind of immune oxysterol that elicits immune response. Recent research indicates the involvement of 27OHChol in metabolic inflammation (meta-inflammation) characterized by chronic responses associated with metabolic irregularities. 27OHChol activates monocytic cells such that they secrete pro-inflammatory cytokines and chemokines, and increase the expression of cell surface molecules such as pattern-recognition receptors that play key roles in immune cell-cell communication and sensing metabolism-associated danger signals. Levels of 27OHChol increase when cholesterol metabolism is disrupted, and the resulting inflammatory responses can contribute to the development and complications of metabolic syndrome, including obesity, insulin resistance, and cardiovascular diseases. Since 27OHChol can induce chronic immune response by activating monocyte-macrophage lineage cells that play a crucial role in meta-inflammation, it is essential to understand the 27OHChol-induced inflammatory responses to unravel the roles and mechanisms of action of this cholesterol metabolite in chronic metabolic disorders.

Keywords

Acknowledgement

This work was supported by a 2-Year Research Grant of Pusan National University.

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