The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Effects of Pyeonggangaeuljihyeol-tang(PGJT) Extract on Anti-inflammatory, Antioxidant and Anti-aging

평간개울지혈탕(平肝開鬱止血湯)의 항염증, 항산화 및 항노화에 미치는 영향

  • Kyoung Won Lee (Dept. Of Ophtalmology & Otolaryngology & Dermatology of Korean Medicine, Semyung University College of Korean Medicine) ;
  • Young Chae Song (Dept. Of Ophtalmology & Otolaryngology & Dermatology of Korean Medicine, Semyung University College of Korean Medicine) ;
  • Hee Taek Kim (Dept. Of Ophtalmology & Otolaryngology & Dermatology of Korean Medicine, Semyung University College of Korean Medicine)
  • 이경원 (세명대학교 한의과대학 한방안이비인후피부과) ;
  • 송영채 (세명대학교 한의과대학 한방안이비인후피부과) ;
  • 김희택 (세명대학교 한의과대학 한방안이비인후피부과)
  • Received : 2024.01.05
  • Accepted : 2024.02.01
  • Published : 2024.02.25
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Abstract

Objectives : The purpose of this study is to confirm the anti-inflammatory, antioxidant and anti-aging efficacy of Pyeonggangaeuljihyeol-tang(PGJT) extract. Methods : In order to confirm the anti-inflammatory activity of PGJT extract, the inhibitory effect on NO PGE2 production were evaluated and the expression level of iNOS, COX-2 and IL-6 mRNA were measured through qRT-PCR, Antioxidant activity was evaluated for radical scavenging activity using DPPH and ABTS, anti-aging activity was evaulated for collagenase, elastase, tyrosinase and L-DOPA oxidation inhibitory activity. Results : PGJT extract shows anti-inflammatory effect by inhibiting the production of NO and PGE2 by reducing the expression level of iNOS, COX-2 and IL-6 mRNA, antioxidant effect by increasing DPPH and ABTS scavenging abillity in a concentration dependent manner. In addition, the anti-aging effect was confirmed by inhibiting collagenase, elastase, tyrosinase production and L-DOPA oxidation. Conclusion : This suggests that PGJT showed an overall excellent anti-inflammatory effect and an inhibitory effect on the activity of antioxidant and anti-aging related enzymes.

Keywords

References

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