Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Pre-exposure Prophylaxis Adherence Among Men Who Have Sex With Men: A Systematic Review and Meta-analysis

  • Received : 2023.08.01
  • Accepted : 2023.11.23
  • Published : 2024.01.31
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Abstract

Objectives: The effectiveness and efficiency of pre-exposure prophylaxis (PrEP) in reducing the transmission of human immunodeficiency virus (HIV) among men who have sex with men (MSM) relies on how widely it is adopted and adhered to, particularly among high-risk groups of MSM. The meta-analysis aimed to collect and analyze existing evidence on various factors related to PrEP adherence in MSM, including demographic characteristics, sexual behaviors, substance use, and psychosocial factors. Methods: The meta-analysis followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search included articles published between January 2018 and December 2022, obtained from the PubMed, ScienceDirect, and Scopus databases. The studies that were included in the analysis reported the proportion of MSM who demonstrated adherence to PrEP and underwent quality appraisal using the Newcastle-Ottawa Scale. Results: Of the 268 studies initially identified, only 12 met the inclusion criteria and were included in the final meta-analysis. The findings indicated that education (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12 to 2.40), number of sexual partners (OR, 1.16; 95% CI, 1.02 to 1.31), engaging in sexual activities with an human immunodeficiency virus-positive partner (OR, 1.59; 95% CI, 1.16 to 2.26), substance use (OR, 0.83; 95% CI, 0.70 to 0.99), and lower levels of depression (OR, 0.55; 95% CI, 0.37 to 0.82) were associated with higher rates of PrEP adherence among MSM. Conclusions: Despite these findings, further research is necessary to investigate PrEP adherence more comprehensively. The findings of this meta-analysis can be utilized to inform interventions aimed at improving PrEP adherence among MSM and provide directions for future research in this area.

Keywords

References

  1. World Health Organization. HIV and AIDS; 2018 [cited 2023 Jun 15]. Available from: https://www.who.int/news-room/fact-sheets/detail/hiv-aids
  2. Ochonye B, Folayan MO, Fatusi AO, Bello BM, Ajidagba B, Emmanuel G, et al. Sexual practices, sexual behavior and HIV risk profile of key populations in Nigeria. BMC Public Health 2019; 19(1):1210. https://doi.org/10.1186/s12889-019-7553-z
  3. Risher K, Mayer KH, Beyrer C. HIV treatment cascade in MSM, people who inject drugs, and sex workers. Curr Opin HIV AIDS 2015;10(6):420-429. https://doi.org/10.1097/COH.0000000000000200
  4. Centers for Disease Control and Prevention, US Public Health Service. Preexposure prophylaxis for the prevention of HIV infection in the United States-2017 update: a clinical practice guideline; 2018 [cited 2023 Jul 14]. Available from: https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2017.pdf
  5. Grulich AE, Guy R, Amin J, Jin F, Selvey C, Holden J, et al. Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV pre-exposure prophylaxis in men who have sex with men: the EPIC-NSW prospective cohort study. Lancet HIV 2018;5(11):e629-e637. https://doi.org/10.1016/S2352-3018(18)30215-7
  6. Buchbinder SP. Maximizing the benefits of HIV preexposure prophylaxis. Top Antivir Med 2018;25(4):138-142.
  7. Gillespie D, Couzens Z, de Bruin M, Hughes DA, Jones A, Ma R, et al. PrEP use, sexual behaviour, and PrEP adherence among men who have sex with men living in Wales prior to and during the COVID-19 pandemic. AIDS Behav 2022;26(8):2746-2757. https://doi.org/10.1007/s10461-022-03618-4
  8. Vuylsteke B, Reyniers T, De Baetselier I, Nostlinger C, Crucitti T, Buyze J, et al. Daily and event-driven pre-exposure prophylaxis for men who have sex with men in Belgium: results of a prospective cohort measuring adherence, sexual behaviour and STI incidence. J Int AIDS Soc 2019;22(10):e25407. https://doi.org/10.1002/jia2.25407
  9. Qu D, Zhong X, Xiao G, Dai J, Liang H, Huang A. Adherence to pre-exposure prophylaxis among men who have sex with men: a prospective cohort study. Int J Infect Dis 2018;75:52-59. https://doi.org/10.1016/j.ijid.2018.08.006
  10. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg 2021;88: 105906. https://doi.org/10.1016/j.ijsu.2021.105906
  11. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25(9):603-605. https://doi.org/10.1007/s10654-010-9491-z
  12. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-560. https://doi.org/10.1136/bmj.327.7414.557
  13. Eubanks A, Coulibaly B, Dembele Keita B, Anoma C, Dah TT, Mensah E, et al. Socio-behavioral correlates of pre-exposure prophylaxis use and correct adherence in men who have sex with men in West Africa. BMC Public Health 2022;22(1):1832. https://doi.org/10.1186/s12889-022-14211-8
  14. Gao Y, Hu Q, Leuba SI, Jia L, Wang H, Huang X, et al. Medication non-adherence and condomless anal intercourse increased substantially during the COVID-19 pandemic among MSM PrEP users: a retrospective cohort study in four Chinese metropolises. Front Med (Lausanne) 2022;9:738541. https://doi. org/10.3389/fmed.2022.738541
  15. Grinsztejn B, Hoagland B, Moreira RI, Kallas EG, Madruga JV, Goulart S, et al. Retention, engagement, and adherence to pre-exposure prophylaxis for men who have sex with men and transgender women in PrEP Brasil: 48 week results of a demonstration study. Lancet HIV 2018;5(3):e136-e145. https://doi.org/10.1016/S2352-3018(18)30008-0
  16. Hojilla JC, Vlahov D, Glidden DV, Amico KR, Mehrotra M, Hance R, et al. Skating on thin ice: stimulant use and sub-optimal adherence to HIV pre-exposure prophylaxis. J Int AIDS Soc 2018; 21(3):e25103. https://doi.org/10.1002/jia2.25103
  17. Liu J, Deng R, Lin B, Pan H, Gao Y, Dai J, et al. Risk management on pre-exposure prophylaxis adherence of men who have sex with multiple men: a multicenter prospective cohort study. Risk Manag Healthc Policy 2021;14:1749-1761. https://doi.org/10.2147/RMHP.S295114
  18. Monteiro Spindola Marins L, Silva Torres T, Luz PM, Moreira RI, Leite IC, Hoagland B, et al. Factors associated with self-reported adherence to daily oral pre-exposure prophylaxis among men who have sex with man and transgender women: PrEP Brasil study. Int J STD AIDS 2021;32(13):1231-1241. https://doi.org/10.1177/09564624211031787
  19. Okafor CN, Hucks-Ortiz C, Hightow-Weidman LB, Magnus M, Emel L, Beauchamp G, et al. Brief report: associations between self-reported substance use behaviors and PrEP acceptance and adherence among black MSM in the HPTN 073 study. J Acquir Immune Defic Syndr 2020;85(1):23-29. https://doi.org/10.1097/QAI.0000000000002407
  20. Seekaew P, Nguyen E, Sungsing T, Jantarapakde J, Pengnonyang S, Trachunthong D, et al. Correlates of nonadherence to key population-led HIV pre-exposure prophylaxis services among Thai men who have sex with men and transgender women. BMC Public Health 2019;19(1):328. https://doi.org/10.1186/s12889-019-6645-0
  21. Wang H, Zhang J, Chu Z, Hu Q, Dong W, Huang X, et al. Risktaking behaviors and adherence to HIV pre-exposure prophylaxis in users of geosocial networking apps: real-world, multicenter study. J Med Internet Res 2020;22(10):e22388. https://doi.org/10.2196/22388
  22. Wheeler DP, Fields SD, Beauchamp G, Chen YQ, Emel LM, Hightow-Weidman L, et al. Pre-exposure prophylaxis initiation and adherence among Black men who have sex with men (MSM) in three US cities: results from the HPTN 073 study. J Int AIDS Soc 2019;22(2):e25223. https://doi.org/10.1002/jia2.25223
  23. Whitfield DL, Beauchamp G, Fields S, Nelson L, Magnus M, Dacus JD, et al. Risk compensation in HIV PrEP adherence among Black men who have sex with men in HPTN 073 study. AIDS Care 2021;33(5):633-638. https://doi.org/10.1080/09540121.2020.1810618
  24. Wu HJ, Wen-Wei Ku S, Chang HH, Li CW, Ko NY, Strong C. Imperfect adherence in real life: a prevention-effective perspective on adherence to daily and event-driven HIV pre-exposure prophylaxis among men who have sex with men - a prospective cohort study in Taiwan. J Int AIDS Soc 2021;24(5):e25733. https://doi.org/10.1002/jia2.25733
  25. Aderemi-Williams RI, Razaq AR, Abah IO, Opanuga OO, Akanmu AS. Adolescents and young adults knowledge, adherence and experiences while on antiretroviral therapy in a tertiary hospital in Lagos, Nigeria: a mixed-method study. J Int Assoc Provid AIDS Care 2021;20:23259582211062754. https://doi.org/10.1177/23259582211062754
  26. Musinguzi N, Kidoguchi L, Mugo NR, Ngure K, Katabira E, Celum CL, et al. Adherence to recommendations for ART and targeted PrEP use among HIV serodiscordant couples in East Africa: the "PrEP as a bridge to ART" strategy. BMC Public Health 2020;20(1):1621. https://doi.org/10.1186/s12889-020-09712-3
  27. Sack DE, De Schacht C, Paulo P, Graves E, Emilio AM, Matino A, et al. Pre-exposure prophylaxis use among HIV serodiscordant couples: a qualitative study in Mozambique. Glob Health Action 2021;14(1):1940764. https://doi.org/10.1080/16549716.2021.1940764
  28. Gebru NM, Canidate SS, Liu Y, Schaefer SE, Pavila E, Cook RL, et al. Substance use and adherence to HIV pre-exposure prophylaxis in studies enrolling men who have sex with men and transgender women: a systematic review. AIDS Behav 2023; 27(7):2131-2162. https://doi.org/10.1007/s10461-022-03948-3
  29. Smith R, Schwartenbeck P, Stewart JL, Kuplicki R, Ekhtiari H, Paulus MP, et al. Imprecise action selection in substance use disorder: evidence for active learning impairments when solving the explore-exploit dilemma. Drug Alcohol Depend 2020; 215:108208. https://doi.org/10.1016/j.drugalcdep.2020.108208
  30. Pasipanodya EC, Li MJ, Jain S, Sun X, Tobin J, Ellorin E, et al. Greater levels of self-reported adherence to pre-exposure prophylaxis (PrEP) are associated with increased condomless sex among men who have sex with men. AIDS Behav 2020; 24(11):3192-3204. https://doi.org/10.1007/s10461-020-02881-7
  31. Viamonte M, Ghanooni D, Reynolds JM, Grov C, Carrico AW. Running with scissors: a systematic review of substance use and the pre-exposure prophylaxis care continuum among sexual minority men. Curr HIV/AIDS Rep 2022;19(4):235-250. https://doi.org/10.1007/s11904-022-00608-y
  32. Hillis A, Germain J, Hope V, McVeigh J, Van Hout MC. Pre-exposure prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM): a scoping review on PrEP service delivery and programming. AIDS Behav 2020;24(11):3056-3070. https://doi.org/10.1007/s10461-020-02855-9
  33. Westmoreland DA, Patel VV, D'Angelo AB, Nash D, Grov C. Sociocultural influences on attitudes towards pre-exposure prophylaxis (PrEP), history of PrEP use, and future PrEP use in HIVvulnerable cisgender men who have sex with men across the U.S. Ann LGBTQ Public Popul Health 2020;1(2):128-158. https://doi.org/10.1891/lgbtq-2020-0005
  34. Shuper PA, Joharchi N, Bogoch II, Loutfy M, Crouzat F, El-Helou P, et al. Alcohol consumption, substance use, and depression in relation to HIV pre-exposure prophylaxis (PrEP) nonadherence among gay, bisexual, and other men-who-have-sex-withmen. BMC Public Health 2020;20(1):1782. https://doi.org/10.1186/s12889-020-09883-z
  35. Colson PW, Franks J, Wu Y, Winterhalter FS, Knox J, Ortega H, et al. Adherence to pre-exposure prophylaxis in black men who have sex with men and transgender women in a community setting in Harlem, NY. AIDS Behav 2020;24(12):3436-3455. https://doi.org/10.1007/s10461-020-02901-6
  36. Velloza J, Baeten JM, Haberer J, Ngure K, Irungu E, Mugo NR, et al. Effect of depression on adherence to oral PrEP among men and women in East Africa. J Acquir Immune Defic Syndr 2018;79(3):330-338. https://doi.org/10.1097/QAI.0000000000001821
  37. Velloza J, Heffron R, Amico KR, Rowhani-Rahbar A, Hughes JP, Li M, et al. The effect of depression on adherence to HIV preexposure prophylaxis among high-risk South African women in HPTN 067/ADAPT. AIDS Behav 2020;24(7):2178-2187. https://doi.org/10.1007/s10461-020-02783-8
  38. Peng L, Cao W, Gu J, Hao C, Li J, Wei D, et al. Willingness to use and adhere to HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in China. Int J Environ Res Public Health 2019;16(14):2620. https://doi.org/10.3390/ijerph16142620
  39. Soares F, Magno L, da Silva LA, Guimaraes MD, Leal AF, Knauth D, et al. Perceived risk of HIV infection and acceptability of PrEP among men who have sex with men in Brazil. Arch Sex Behav 2023;52(2):773-782. https://doi.org/10.1007/s10508-022-02342-3
  40. Mayer KH, Agwu A, Malebranche D. Barriers to the wider use of pre-exposure prophylaxis in the United States: a narrative review. Adv Ther 2020;37(5):1778-1811. https://doi.org/10.1007/s12325-020-01295-0