Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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β-glucan from Aureobasidium pullulans SM-2001 prevents ovariectomy (OVX)-induced osteoporosis in rats

Ovariectomy(OVX) 유도 골다공증 모델에서의 흑효모배양 베타글루칸의 뼈 건강 개선 효과

  • Jong Min Kim (Aging and Metabolism Research Group, Korea Food Research Institute) ;
  • Hyun-Jin Na (Aging and Metabolism Research Group, Korea Food Research Institute) ;
  • Yiseul Kim (Aging and Metabolism Research Group, Korea Food Research Institute) ;
  • Jae Gu Kim (Aging and Metabolism Research Group, Korea Food Research Institute) ;
  • Sang-Hee Lee (Aging and Metabolism Research Group, Korea Food Research Institute) ;
  • Min Jeong Cho (Glucan Co. Ltd.) ;
  • Young-Suk Kim (Glucan Co. Ltd.) ;
  • Mi Jeong Sung (Aging and Metabolism Research Group, Korea Food Research Institute)
  • 김종민 (한국식품연구원 노화대사연구단) ;
  • 나현진 (한국식품연구원 노화대사연구단) ;
  • 김이슬 (한국식품연구원 노화대사연구단) ;
  • 김재구 (한국식품연구원 인프라지원팀) ;
  • 이상희 (한국식품연구원 노화대사연구단) ;
  • 조민정 ((주)글루칸) ;
  • 김영숙 ((주)글루칸) ;
  • 성미정 (한국식품연구원 노화대사연구단)
  • Received : 2024.11.12
  • Accepted : 2024.11.19
  • Published : 2024.11.30
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Abstract

Objective : This study was conducted to analyze the protective effect of polycan on osteoporosis in ovariectomy (OVX)-induced rat model. Methods : In this study, we investigated the protective effect on estrogen-deficiency-induced osteoporosis. Rats were randomly assigned into SHAM-operated group or OVX subgroups such as OVX, OVX+polycan, and OVX+estradiol (Es). We determined changes in body, uterine, and fat weight. We analyzed by determining the microtrabecular bone structure, and serum biochemical parameters. Results : Polycan decreased OVX-induced body and fat weight increase, and increased OVX-decreased uterine weight, bone mineral density. Also, polycan treatment prevented determined by a decrease in the levels of serum bone turnover markers BALP, sRANKL, and TRACP. μ-CT analysis showed that the polycan treatment prevented decreases in bone volume/tissue volume, trabecular number, and trabecular thickness, while also preventing an increase in trabecular separation. polycan could protect OVX-induced loss of bone mass and deterioration in trabecular microarchitecture by suppressing bone turnover. Conclusion : Therefore, we suggest that treatment with Polycan might be a potential alternative therapy for treating osteoporosis.

Keywords

Acknowledgement

본 결과는 2024년 한국식품산업클러스터진흥원 기업기술지원사업(과제번호G0240700)의 지원을 받아 수행된 연구입니다.

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