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Tumor-like lymphoplasmacytic conjunctivitis in the third eyelid in a dog

  • Hyeonu Sung (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Jisoo Park (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Jury Kim (Bundang Brighteye Animal Hospital) ;
  • Seonmi Kang (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Gillian C. Shaw (Comparative Ocular Pathology Laboratory of Wisconsin, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin) ;
  • Kangmoon Seo (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
  • Received : 2023.09.06
  • Accepted : 2023.12.19
  • Published : 2024.01.31

Abstract

This report aims to describe a case of tumor-like lymphoplasmacytic conjunctivitis in a 7-year-old spayed-female Pomeranian. On complete ophthalmic examination, a mass with papillary projections was noted on the bulbar surface of the right third eyelid. Debulking of the mass was performed while preserving as much of the third eyelid as possible. On the histopathological examination, the mass was diagnosed as lymphoplasmacytic conjunctivitis with mild epithelial hyperplasia. Although a slight regrowth of the mass was noted 3 weeks after surgery, intralesional injection of triamcinolone acetonide led to its disappearance. There was no further recurrence after 5 months.

Keywords

Acknowledgement

This study was supported by BK21 FOUR Future Veterinary Medicine Leading Education and Research Center and the Authorship Responsibility and License Agreement Form (RIVS), College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea. In addition, this research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2021R1I1A1A01058695).

References

  1. Gelatt KN, Ben-Shlomo G, Gilger BC, Hendrix DVH, Kern TJ, Plummer CE. Veterinary Ophthalmology. 6th ed. Hoboken: John Wiley & Sons; 2021, 1045-1071.
  2. Gelatt KN, Gelatt JP, Plummer CE. Veterinary Ophthalmic Surgery. 2nd ed. St. Louis: Elsevier; 2022, 165-166.
  3. Dees DD, Schobert CS, Dubielzig RR, Stein TJ. Third eyelid gland neoplasms of dogs and cats: a retrospective histopathologic study of 145 cases. Vet Ophthalmol. 2016;19(2):138-143. https://doi.org/10.1111/vop.12273
  4. Hong IH, Bae SH, Lee SG, Park JK, Ji AR, Ki MR, et al. Mucosa-associated lymphoid tissue lymphoma of the third eyelid conjunctiva in a dog. Vet Ophthalmol. 2011;14(1):61-65. https://doi.org/10.1111/j.1463-5224.2010.00843.x
  5. Olbertz L, Lima L, Langohr I, Werner J, Teixeira L, Montiani-Ferreira F. Supposed primary conjunctival lymphoma in a dog. Vet Ophthalmol. 2013;16 Suppl 1:100-104. https://doi.org/10.1111/j.1463-5224.2012.01027.x
  6. McCowan C, Malcolm J, Hurn S, O'Reilly A, Hardman C, Stanley R. Conjunctival lymphoma: immunophenotype and outcome in five dogs and three cats. Vet Ophthalmol. 2014;17(5):351-357. https://doi.org/10.1111/vop.12083
  7. Pena MA, Leiva M. Canine conjunctivitis and blepharitis. Vet Clin North Am Small Anim Pract. 2008;38(2):233-249. https://doi.org/10.1016/j.cvsm.2007.12.001
  8. Crispin SM. Notes on Veterinary Ophthalmology. Oxford: Blackwell Publishing; 2005, 80-103.
  9. Keller SM, Vernau W, Moore PF. Clonality testing in veterinary medicine: a review with diagnostic guidelines. Vet Pathol. 2016;53(4):711-725. https://doi.org/10.1177/0300985815626576
  10. Vascellari M, Multari D, Mutinelli F. Unicentric extranodal lymphoma of the upper eyelid conjunctiva in a dog. Vet Ophthalmol. 2005;8(1):67-70. https://doi.org/10.1111/j.1463-5224.2005.04053.x
  11. Mannami T, Yoshino T, Oshima K, Takase S, Kondo E, Ohara N, et al. Clinical, histopathological, and immunogenetic analysis of ocular adnexal lymphoproliferative disorders: characterization of malt lymphoma and reactive lymphoid hyperplasia. Mod Pathol. 2001;14(7):641-649. https://doi.org/10.1038/modpathol.3880366
  12. Holmberg BJ, Maggs DJ. The use of corticosteroids to treat ocular inflammation. Vet Clin North Am Small Anim Pract. 2004;34(3):693-705. https://doi.org/10.1016/j.cvsm.2003.12.007
  13. Regnier A, Toutain PL, Alvinerie M, Periquet B, Ruckebusch Y. Adrenocortical function and plasma biochemical values in dogs after subconjunctival treatment with methylprednisolone acetate. Res Vet Sci. 1982;32(3):306-310. https://doi.org/10.1016/S0034-5288(18)32385-3
  14. Zaka-ur-Rab S, Mahmood S, Shukla M, Zakir SM, Khan BA, Owais M. Systemic absorption of triamcinolone acetonide after posterior sub-Tenon injection. Am J Ophthalmol. 2009;148(3):414-419. https://doi.org/10.1016/j.ajo.2009.03.031
  15. Ewald MM, Rankin AJ, Meekins JM, Magnin G, KuKanich B. Prednisolone and dexamethasone are systemically absorbed after topical application of ophthalmic suspensions in healthy dogs. Am J Vet Res. 2022;83(4):339-348. https://doi.org/10.2460/ajvr.21.04.0059